The effect of polyunsaturated fatty acids on cardiovascular risk factors and urinary mercury in workers employed at electrolytic production of chlorine

• Authors: Anna Skoczyńska , Maciej Cyran , Barbara Turczyn , Anna Wojakowska , Beata Smyk , Marta Skoczyńska

Abstracts

EN

ObjectivesWhile inorganic mercury is being gradually withdrawn from industry, environmental exposure to mercury is recognized as one of the greatest present toxicological problems. The aim of this study was to evaluate the effect of polyunsaturated fatty acids (PUFAs) supplementation on selected cardiovascular risk factors and the urinary mercury (Hg-U) concentration in workers occupationally exposed to mercury vapor.Material and MethodsOverall, 38 workers of an electrolyzer hall (Hg-U: 46.6±35.7 μg/g creatinine) and a control group of 60 employees not exposed to Hg (Hg-U: 4.3±15.5 μg/g creatinine) were included in a clinical cross-over study. Clinical and laboratory tests were carried out 4 times: before and after a 3-month period of PUFAs supplementation (1000 mg daily), then after a 3-month break, and then after another 3-month period of PUFAs supplementation.ResultsThe baseline heart rate (HR) and serum triglyceride levels were higher in the Hg-exposed workers than in the controls, whereas systolic blood pressure (SBP) and cholesterol (C) levels exceeded normal values in both groups. There was a positive correlation between high-density lipoprotein 3 cholesterol (HDL3-C) and Hg-U levels. The PUFAs use was associated with a decrease in both HR and SBP. After the first stage of supplementation, a decrease in the Hg-U concentration was observed. In a multivariate logistic regression model, decreases in Hg-U were associated only with exposure to mercury; ORΔHg = 0.562 (95% CI: 0.323–0.979), p < 0.042. After the second 3-month period of PUFAs supplementation, a significant association between HDL3-C and a Hg-U decrease was shown: OR HDL3 = 1.222 (95% CI: 1.01–1.46), p < 0.033.ConclusionsIn the workers exposed to mercury vapor, PUFAs supplementation led to some beneficial effects on HR and SBP. The first stage of supplementation was associated with a decrease in Hg-U in which HDL3 metabolism probably plays an important role.

Keywords

EN

blood pressure; heart rate; HDL-C; PUFA; mercury exposure; urinary Hg

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2021
• Volume: 34
• Issue: 4
• Pages: 551-564

Dates

published

2021

Contributors

author

Anna Skoczyńska

• Wroclaw Medical University, Wrocław, Poland (Department of Internal and Occupational Medicine and Hypertension)

author

Maciej Cyran

• Maria Sklodowska-Curie Medical Academy, Warsaw, Poland

author

Barbara Turczyn

• Wroclaw Medical University, Wrocław, Poland (Department of Internal and Occupational Medicine and Hypertension)

author

Anna Wojakowska

• Wroclaw Medical University, Wrocław, Poland (Department of Internal and Occupational Medicine and Hypertension)

author

Beata Smyk

• Wroclaw Medical University, Wrocław, Poland (Department of Internal and Occupational Medicine and Hypertension)

author

Marta Skoczyńska

• Wroclaw Medical University, Wrocław, Poland (Department of Rheumatology and Internal Diseases)

Identifiers

DOI

10.13075/ijomeh.1896.01597

Biblioteka Nauki

2086436