Can the effects of chromium compounds exposure be modulated by vitamins and microelements?

• Authors: Monika Sijko , Beata Janasik , Wojciech Wąsowicz , Lucyna Kozłowska

Abstracts

EN

Chromium (Cr) is a very common element. It occurs in 2 oxidation states, Cr(III) and Cr(VI). Although Cr(III) is not considered an element essential for mammals, it raises lots of controversy due to its role in the body. While Cr(III) action should be considered an effect of pharmacological action, Cr(VI) is included in the first group of carcinogens for humans. Moreover, it induces numerous pathological changes in the respiratory, urinary, reproductive and digestive systems. In addition, Cr(VI) is used in many industry branches, causing millions of workers all over the world to be exposed to Cr(VI) compounds. A considerable number of the occupationally exposed individuals are in favor of a deep analysis of the mechanisms of Cr(VI) action and a search for a way to reduce its negative impact on the human body. Numerous reactive oxygen species inducing oxidative stress and causing various damage are produced during Cr(VI) reduction in the cells. A good balance between antioxidants and pro-oxidants can reduce Cr(VI)-induced damage. The influence of vitamins and microelements on the adverse Cr(VI) effects has no systematic research results summary. Therefore, this work focuses on the role of dietary antioxidants such as vitamins and microelements in the prevention of Cr(VI) adverse health effects. Numerous studies have revealed a protective influence of vitamins (mainly vitamins E and C) as well as microelements (especially selenium) on the reduction of Cr(VI)-induced adverse changes. A potential protective effect of these ingredients may be useful in occupational groups that are particularly exposed to Cr(VI). However, more research in this area is required.

Keywords

EN

zinc; folic acid; selenium; hexavalent chromium; vitamin E; vitamin C

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2021
• Volume: 34
• Issue: 4
• Pages: 461-490

Dates

published

2021

Contributors

author

Monika Sijko

• Warsaw University of Life Sciences, Warsaw, Poland (Department of Dietetics, Faculty of Human Nutrition)

author

Beata Janasik

• Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Biological and Environmental Monitoring)

author

Wojciech Wąsowicz

• Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Biological and Environmental Monitoring)

author

Lucyna Kozłowska

• Warsaw University of Life Sciences, Warsaw, Poland (Department of Dietetics, Faculty of Human Nutrition)

Identifiers

DOI

10.13075/ijomeh.1896.01706

Biblioteka Nauki

2086573