Assessment of buccal mucosa genotoxicity in insecticide-exposed urban fumigators in Cali, Colombia

• Authors: Elizabeth Londoño-Velasco , Helberg Asencio-Santofimio , Jose G. Ortega-Avila , Aldair B. Rosero-Caldón , Juan C. Aristizabal-Grisales , Laura Rey-Henao , Jairo A. Vargas-Rivera , Enrique Vergara-Escudero

Abstracts

EN

Objectives This study aimed to evaluate cytogenetic damage in the buccal mucosa of non-exposed subjects (N = 33) and insecticide-exposed fumigators (N = 31) in the urban area of Cali, Colombia. Material and Methods Through a questionnaire sociodemographic data, anthropometric measurements, state of health, and lifestyle were collected. Buccal micronucleus cytome (BMCyt) assay was using for evaluate cytogenetic damage. Results The study showed that all fumigators used adequate personal protective equipment (PPE) and had low alcohol consumption. The authors did not find significant differences in BMCyt biomarkers between the groups (p > 0.05). Multivariate analysis showed a 13% increase in micronucleus (MN) frequency for every year of increasing age (OR = 1.13, p = 0.029), and higher MN with the decrease in daily fruit consumption (OR = 4.71, p = 0.084), without statistical significance. Conclusions The results between groups could be related to healthy habits and PPE use among the subjects.

Keywords

EN

insecticides; occupational exposure; buccal micronucleus cytome assay; DNA damage; biomarker; personal protective equipment

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2024
• Volume: 37
• Issue: 1
• Pages: 128-137

Dates

published

2024

Contributors

author

Elizabeth Londoño-Velasco

• Pontificia Universidad Javeriana Cali, Cali, Colombia (Faculty of Health Sciences, Department of Basic Health Sciences)

author

Helberg Asencio-Santofimio

• Pontificia Universidad Javeriana Cali, Cali, Colombia (Faculty of Health Sciences, Department of Basic Health Sciences)

author

Jose G. Ortega-Avila

• Pontificia Universidad Javeriana Cali, Cali, Colombia (Faculty of Health Sciences, Department of Basic Health Sciences)

author

Aldair B. Rosero-Caldón

• Pontificia Universidad Javeriana Cali, Cali, Colombia (Faculty of Health Sciences, Department of Basic Health Sciences)

author

Juan C. Aristizabal-Grisales

• Pontificia Universidad Javeriana Cali, Cali, Colombia (Faculty of Health Sciences, Department of Public Health and Epidemiology)

author

Laura Rey-Henao

• Pontificia Universidad Javeriana Cali, Cali, Colombia (Faculty of Health Sciences, Department of Basic Health Sciences)

author

Jairo A. Vargas-Rivera

• Pontificia Universidad Javeriana Cali, Cali, Colombia (Faculty of Health Sciences, Department of Basic Health Sciences)

author

Enrique Vergara-Escudero

• University of Minnesota, Minneapolis, USA (Department of Anesthesiology)

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Identifiers

DOI

10.13075/ijomeh.1896.02292

Biblioteka Nauki

28762056