Occupational exposure to antineoplastic drugs in hospital environments: potential risk associated with contact with cyclophosphamide- and ifosfamide-contaminated surfaces

• Authors: Nicola Mucci , Stefano Dugheri , Andrea Farioli† , Giacomo Garzaro , Venerando Rapisarda , Marcello Campagna , Alessandro Bonari , Giulio Arcangeli

Abstracts

EN

BackgroundCyclophosphamide (CP) and ifosfamide (IP) contaminations have been detected in hospital environments. This study was conducted to determine if there was any contamination in the spaces (floors and door handles) between the hospital exit and the antineoplastic drugs (ADs) preparation and administration units. At the same time, the authors proposed a new automation of the analytical procedure to considerably decrease the time needed for sample preparation and analysis.Material and MethodsTo evaluate the ADs contamination of surfaces, 829 wipe tests were performed in a campaign involving 3 hospitals located in Italy. Sampling was performed using an innovative kit. The levels of ADs were measured in each wipe sample using liquid chromatography/triple quadrupole.ResultsOn-line solid-phase extraction guarantees the construction of a robust and reproducible analytical method. The CP and IP recoveries from stainless steel, polycarbonate and polyvinyl chloride ranged >80%, and the wipe holders and the automation tested ensured desorption efficiencies close to 100% for both the ADs. Of the 552 wipes taken on the spaces between the hospital exit and the preparation, administration and pharmacy warehouse units, 22 were greater than or equal to the limit of quantification, all adjacent to the administration units.ConclusionsThis study provides an insight into the exposure situation against ADs residues. In order to improve environmental monitoring programs, the authors propose to evaluate the ADs contamination also outside the preparation, administration and pharmacy warehouse units.

Keywords

EN

occupational exposure; cyclophosphamide; antineoplastic drugs; ifosfamide; wipe test; surface contamination

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: Medycyna Pracy
• Year: 2020
• Volume: 71
• Issue: 5
• Pages: 519-529

Dates

published

2020

Contributors

author

Nicola Mucci

• University of Florence, Florence, Italy (Department of Experimental and Clinical Medicine)

author

Stefano Dugheri

• Careggi University Hospital, Florence, Italy (Industrial Hygiene and Toxicology Laboratory, Occupational Medicine Unit)

author

Andrea Farioli†

• University of Bologna, Bologna, Italy (Department of Medical and Surgical Sciences)

author

Giacomo Garzaro

• University of Turin, Turin, Italy (Department of Public Health and Pediatric Sciences)

author

Venerando Rapisarda

• University of Catania, Catania, Italy (Department of Clinical and Experimental Medicine)

author

Marcello Campagna

• University of Cagliari, Cagliari, Italy (Department of Medical Sciences and Public Health)

author

Alessandro Bonari

• University of Florence, Florence, Italy (Department of Experimental and Clinical Medicine)

author

Giulio Arcangeli

• University of Florence, Florence, Italy (Department of Experimental and Clinical Medicine)

Identifiers

DOI

10.13075/mp.5893.00931

Biblioteka Nauki

2085717