Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome

• Authors: Sheu Kadiri Rahamon , Olatunbosun Ganiyu Arinola , Mabel Ayebatonyo Charles-Davies , Kehinde Sola Akinlade , John Ayodele Olaniyi , Adesoji Adedipe Fasanmade , Oyediran Emmanuel Oyewole , Mayowa Ojo Owolabi , Jane Roli Adebusuyi , Olufunke Olayemi Hassan , Muhammed Babatunde Ajobo , Kehinde Adigun , Maria Onomaghuan Ebesunun , Omolara Olutosin Popoola , Wemimo Omiyale , Emmanuel Oluyemi Agbedana

Abstracts

EN

Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking. Aim. To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS. Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status. Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS. Conclusion. Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.

Keywords

EN

metabolic syndrome; vitamin D; inflammation

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2021
• Issue: 4
• Pages: 306-312

Dates

published

2021

Contributors

author

Sheu Kadiri Rahamon

• Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria
• Department of Immunology, College of Medicine, University of Ibadan, Ibadan, Nigeria

author

Olatunbosun Ganiyu Arinola

• Department of Immunology, College of Medicine, University of Ibadan, Ibadan, Nigeria

author

Mabel Ayebatonyo Charles-Davies

• Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria

author

Kehinde Sola Akinlade

• Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria

author

John Ayodele Olaniyi

• Department of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria

author

Adesoji Adedipe Fasanmade

• Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria

author

Oyediran Emmanuel Oyewole

• Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan, Nigeria

author

Mayowa Ojo Owolabi

• Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria

author

Jane Roli Adebusuyi

• Department of Medical Social Services, University College Hospital, Ibadan, Nigeria

author

Olufunke Olayemi Hassan

• Department of Medical Social Services, University College Hospital, Ibadan, Nigeria

author

Muhammed Babatunde Ajobo

• Dietetics Department, University College Hospital, Ibadan, Nigeria

author

Kehinde Adigun

• Department of Family Medicine, University College Hospital, Ibadan, Nigeria

author

Maria Onomaghuan Ebesunun

• Department of Chemical Pathology, College of Health Sciences, Olabisi Onabanjo University, Ago-Iwoye, Nigeria

author

Omolara Olutosin Popoola

• Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria

author

Wemimo Omiyale

• Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria

author

Emmanuel Oluyemi Agbedana

• Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria

Identifiers

DOI

10.15584/ejcem.2021.4.3

Biblioteka Nauki

2040233