Primary leiomyosarcoma of bones – a rare entity in two different presentations

• Authors: Withanage Don Duminda , Dishan Randika Samarathunga , Appu Arachchige Gayani Harindi Anupama , Rukshan Sooriyarachchi , Paththinikuttige Alexander Gamini Navarathna , Rathnayaka Mudiyanselage Ananda Sarath Rathnayaka , Rubasinha Liyanage Pemith Ranura Liyanage , Ihala Wellala Gunawardena Arachchige Labandi Malhasi

Abstracts

EN

Introduction. Leiomyosarcomas (LMS) originate from smooth muscle cells. They are very rare malignant neoplasms. Bony Leiomyosarcoma is a variant of spindle cell sarcoma, primarily affecting long bones, predominantly the distal femur and the proximal tibia followed by craniofacial skeleton. Aim. To describe clinical presentation and diagnostic approach of primary leiomyosarcoma of bones in two different patients. Description of the cases. Case 1. A 64-year-old male with a fracture of left distal femur after a fall was investigated and found to have a pathological fracture. An open biopsy of the fracture site confirms leiomyosarcoma. Case 2. A 58-year-old previously healthy female presented with a swelling on right side mandibular region. Orthopantomogram radiograph (OPG) of mandible and Cone beam CT (CBCT) mandible was taken initially and revealed a large area of bone destruction of the right side of the mandible associated with a soft tissue mass. Initial incisional biopsy made the diagnosis of spindle cell sarcoma followed by excisional biopsy, which confirms the diagnosis of moderately differentiated leiomyosarcoma. Conclusion. Primary leiomyosarcoma of bones is very rare. Imaging features are helpful in the evaluation of such conditions, but final diagnosis should be based on histopathologic and immunohistochemical features.

Keywords

EN

bones; leiomyosarcoma; malignant neoplasms

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2021
• Issue: 4
• Pages: 333-340

Dates

published

2021

Contributors

author

Withanage Don Duminda

• The National Hospital of Sri Lanka, Colombo, Sri Lanka

author

Dishan Randika Samarathunga

• The National Hospital of Sri Lanka, Colombo, Sri Lanka

author

Appu Arachchige Gayani Harindi Anupama

• The National Dental Hospital, Colombo, Sri Lanka

author

Rukshan Sooriyarachchi

• The National Hospital of Sri Lanka, Colombo, Sri Lanka

author

Paththinikuttige Alexander Gamini Navarathna

• The National Dental Hospital, Colombo, Sri Lanka

author

Rathnayaka Mudiyanselage Ananda Sarath Rathnayaka

• The National Dental Hospital, Colombo, Sri Lanka

author

Rubasinha Liyanage Pemith Ranura Liyanage

• The National Dental Hospital, Colombo, Sri Lanka

author

Ihala Wellala Gunawardena Arachchige Labandi Malhasi

• The National Hospital of Sri Lanka, Colombo, Sri Lanka

Identifiers

DOI

10.15584/ejcem.2021.4.9

Biblioteka Nauki

2040500