Transcranial magnetic stimulation as a new therapeutical approach in autism spectrum disorders and attention deficit hyperactivity disorder – a review

• Authors: Rosa Savino , Anna N. Polito , Antonio Ventriglio , Antonello Bellomo , Fiorenzo Moscatelli , Rita Polito , Anna A. Valenzano , Giovanni Messina , Giuseppe Cibelli

Abstracts

EN

Introduction and aim. Autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD) neurobiology reveals a complex picture of altered excitation-inhibition balance, aberrant neuronal and neurotransmitter activity, and network disorganization that could be addressed through repetitive transcranial magnetic stimulation (TMS). In this paper, we provide a narrative review of the most recent literature on the use of TMS to treat patients with ASD and ADHD. Material and methods. Literature search from 2018 up to November 2022 has been conducted on PubMed database. Keywords reflected diagnoses and treatment modalities of interest. Analysis of the literature. Eleven clinical trials regarding the use of TMS as a therapeutic tool in ASD, and seven studies (of which 3 are case reports) for ADHD have been reported. The dorsolateral prefrontal cortex (DLPFC) is the most frequent area stimulated. Heterogeneity in stimulation parameters, patient age, and outcome measures limited the interpretation of findings. Conclusion. TMS as a therapeutic tool for neurodevelopmental disorders is still in its infancy. To define the real efficacy of TMS, future studies must be randomized, sham-controlled, and double-blind, and should include a larger sample with adequate inclusion/exclusion criteria, and longitudinal follow-up.

Keywords

EN

ADHD; ASD; autism; neuromodulation; neurodevelopmental disorders; TMS

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2023
• Issue: 1
• Pages: 133-144

Dates

published

2023

Contributors

author

Rosa Savino

• Department of Woman and Child, Neuropsychiatry for Child and Adolescent Unit, General Hospital “Riuniti” of Foggia, Foggia, Italy

• https://orcid.org/0000000164390317

author

Anna N. Polito

• Department of Woman and Child, Neuropsychiatry for Child and Adolescent Unit, General Hospital “Riuniti” of Foggia, Foggia, Italy

author

Antonio Ventriglio

• Department of Clinical and Experimental Medicine, Psychiatric Unit, University of Foggia, Foggia, Italy

author

Antonello Bellomo

• Department of Clinical and Experimental Medicine, Psychiatric Unit, University of Foggia, Foggia, Italy

author

Fiorenzo Moscatelli

• Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy

author

Rita Polito

• Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy

author

Anna A. Valenzano

• Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy

author

Giovanni Messina

• Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy

author

Giuseppe Cibelli

• Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy

• https://orcid.org/0000000253712584

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Identifiers

DOI

10.15584/ejcem.2023.1.17

Biblioteka Nauki

2211813