Phytochemical analysis, stability, and antimicrobial activity of eighteen medicinal plants studied against five multi-drug resistant human pathogens

• Authors: G. Dharshana Malya , Jhumpa Bhattacharjee , Sahana Mukherjee , Shubhajyoti Deka , Lahari Saikia , Shoma Paul Nandi

Abstracts

EN

Introduction and aim. Several medicinal plants from India have been reported to be effective against human pathogens, but comprehensive comparative studies are scarce. The aim of this study has been to evaluate and compare the antimicrobial activity, phytochemical composition, and stability at different temperatures and pH of ethanolic extracts of eighteen Indian medicinal plants which are prevalent in North-east India and thrive abundantly. Material and methods. These plants included Syzygium cumini, Cannabis sativa, Camellia sinensis, Murraya koenigii, Alstonia scholaris, Terminalia chebula, Flemingia strobilifera, Azadirachta indica, Prunus persica, Euphorbia thymifolia, Averrhoa carambola, Paderia foetida, Psidium guajava, Spondias pinnata, Garcinia cowa, Litsea cubeba, Micania macrantha, and Phlogocanthus thyrsiflorus. Their potent medicinal properties made them the ideal choice for this study which included the use of agar well diffusion method and phytochemical analysis. Results. Agar well diffusion has been used to test their antibacterial activity, which demonstrated higher antibacterial activity of G. cowa extract against Vibrio cholerae and Staphylococcus aureus, whereas S. pinnata extract was most effective against V. cholerae and Enterococcus faecium. Conclusion. Phytochemical analysis revealed the presence of tannins, alkaloids, saponins, glycosides, steroids, terpenoids, flavonoids, and phenols. The antimicrobial activity of these plant extracts remained stable at higher temperatures and varying pH levels.

Keywords

EN

antibiotic resistance; antimicrobial activity; extracts; medicinal plants; phytochemicals

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2024
• Issue: 4
• Pages: 811-819

Dates

published

2024

Contributors

author

G. Dharshana Malya

• Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India

author

Jhumpa Bhattacharjee

• Assam Medical College and Hospital, Dibrugarh, Assam, India

author

Sahana Mukherjee

• Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India

author

Shubhajyoti Deka

• Assam Medical College and Hospital, Dibrugarh, Assam, India

author

Lahari Saikia

• Assam Medical College and Hospital, Dibrugarh, Assam, India

author

Shoma Paul Nandi

• Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India

• https://orcid.org/0000000314162425

Identifiers

DOI

10.15584/ejcem.2024.4.17

Biblioteka Nauki

62645150