At the turn of the 21st century, the ethical boundaries have been demolished in a dramatic way, especially in reference to the broadly understood human sexuality. An intensively promoted materialist anthropology connected to the reductive vision of human sexuality and sexual life, has created the foundation for anew ideology. Gender theory finds itself well in the postmodernist context, where multi-dimensional determinist conditioning, relativism and temporality of all human intellectual property are highlighted. The Traditional categories as femininity, masculinity, and heterosexuality were rejected and treated as mere archaic stereotypes. According to gender ideologists, in order to prevent discrimination one has to finally start the deconstruction of a patriarchal regime and replace it with anew, egocentric and hedonistic culture. The author of this article presents new challenges for the Catholic vision of the vocation of women and men highlighting the deconstruction of the biological sex, a new anthropology and the far-going transformations in the consciousness, social, cultural and political activity on an international scale.