Paternal occupational exposures and the risk of congenital malformations - A case-control study

• Authors: Mohamed El-Helaly , Kamal Abdel-Elah , Ayman Haussein , Hend Shalaby

Abstracts

EN

Objectives: This study examined the association between certain paternal occupational exposures during the periconceptional period and the risk of congenital malformations. Materials and Methods: A case-control study was carried out from December 2009 to April 2010; on 242 congenital malformation cases and 270 controls. Paternal occupational exposure to certain workplace hazards was assessed by a detailed questionnaire to evaluate the occupational exposure for both fathers and mothers including pesticides, solvents, welding fumes, lead, working with video display terminals (VDTs) and computer monitors. In addition, the questionnaire assessed the presence of other risk factors such as consanguinity, smoking and history of any maternal diseases during the pregnancy with the child. Results: The results revealed that the odds of having a child with congenital malformation was higher (P < 0.01) if the father was occupationally exposed to pesticides (OR: 3.42, 95% CI: 1.97-5.92), solvents (OR: 5.63, 95% CI: 2.77-11.42), or welding fumes (OR: 2.98, 0.99-8.54) during the periconceptional period. However, consanguinity (OR: 1.91, 95% CI: 1.25-2.92) was a risk factor of developing congenital malformations among offspring. Conclusion: Control of workplace exposures and adherence to threshold limit values of those hazards should be adopted to minimize the risk of developing congenital malformations among offspring.

Keywords

EN

paternal; occupational exposure; congenital malformation; risk

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2011
• Volume: 24
• Issue: 2
• Pages: 218-227

Dates

published

2011

Contributors

author

Mohamed El-Helaly

• Department of Public Health and Preventive Medicine, Faculty of Medicine, The Mansoura University, Mansoura, Egypt

author

Kamal Abdel-Elah

• Department of Pediatric Surgery, Faculty of Medicine, The Mansoura University, Mansoura, Egypt

author

Ayman Haussein

• Department of Orthopedics; Faculty of Medicine, The Mansoura University, Mansoura, Egypt

author

Hend Shalaby

• Department of Gynecology and Obstetrics, Faculty of Medicine, The Mansoura University, Mansoura, Egypt

Identifiers

DOI

10.2478/s13382-011-0019-x

Biblioteka Nauki

2185358