Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers

• Authors: Yong Li , Nan-Nan Feng , Guang-Hui Zhang , Qi Wang , Yan-Hui Hao , Ya Nanzhang , Changxu Long , Yongliang Li , Paul W. Brandt-Rauf , Zhao-Lin Xia

Abstracts

EN

Objectives: To investigate the association between polymorphisms in the p53 pathway genes and chromosomal damage in vinyl chloride (VC)-exposed workers. Materials and Methods: Cytokinesis block micronucleus test was performed in 310 VC-exposed workers and 149 non-exposed workers to determine chromosomal damage. The polymerase chain reaction and restriction fragment length polymorphism technique were used to detect six SNPs in the p53 pathway genes involved in the cell cycle. Results: There was a highly significant dose-response relationship between VC exposure and chromosomal damage. Individuals carrying the variant genotypes were at higher risk for chromosomal damage compared with their wild type genotype: p53rs1042522, MDM2 Del1518rs3730485, MDM2rs2279744 and GADD45Ars532446. On the other hand, individuals possessing the variant genotype of CDKN2A rs3088440 had significantly decreased risk compared with the corresponding wild-type. Conclusions: Genetic polymorphisms in P53 pathway genes may have an impact on VC-induced chromosomal damage.

Keywords

EN

VC; occupational exposure; p53 pathway genes; genetic polymorphism

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2013
• Volume: 26
• Issue: 6
• Pages: 825-836

Dates

published

2013

Contributors

author

Yong Li

• Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

author

Nan-Nan Feng

• Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

author

Guang-Hui Zhang

• Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

author

Qi Wang

• Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

author

Yan-Hui Hao

• Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

author

Ya Nanzhang

• Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

author

Changxu Long

• School of Public Health, University of Illinois, Chicago, USA

author

Yongliang Li

• School of Public Health, University of Illinois, Chicago, USA

author

Paul W. Brandt-Rauf

• School of Public Health, University of Illinois, Chicago, USA

author

Zhao-Lin Xia

• Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China

Identifiers

DOI

10.2478/s13382-013-0155-6

Biblioteka Nauki

2179059