Pathophysiology of thromboembolism in patients with COVID-19

• Authors: Yethindra Vityala , Abhijit Krishna , Dinesh Pandla , Krishna Priya Kanteti , Jahnavi Sadhu , HarshaVardhan Boddeti , Tejesh Kintali , Mohammad Shaour Khalid

Abstracts

EN

Introduction and aim. A small number of critically ill patients with coronavirus disease (COVID-19) develop thromboembolism (arterial or venous), both micro- and macrovascular complications such as deep vein thrombosis, pulmonary embolism, and pulmonary arterial thrombosis. The objective of the study is to describe the pathophysiology of venous thromboembolism in patients with COVID-19. Material and methods. In this article a narrative review regarding pathophysiology of thromboembolism in patients with COVID-19. Analysis of the literature. The development of coagulopathy is a consequence of the intense inflammatory response associated with hypercoagulability, platelet activation, and endothelial dysfunction. The pathophysiology that relates pulmonary thromboembolism (PTE) with COVID-19 is associated with a hypercoagulable state. PTE is suspected in hospitalized patients presenting dyspnea, decreased oxygen requirement, hemodynamic instability, and dissociation between hemodynamic and respiratory changes. In COVID-19-associated coagulopathy, initially, patients present with elevated levels of fibrinogen and D-dimer, with minimal changes in prothrombin time and platelet count. The main risk factor for the development of pulmonary embolism is the increase in D-dimer that is associated with the development of PTE. The administration of iodine-based contrast agent to patients with COVID-19 would affect P-creatinine and renal function, where Ultrasound is viewed as cost-effective and highly portable, can be performed at the bedside. Conclusion. Acute respiratory distress syndrome severity in patients with COVID-19 can explain PTE as a consequence of an exaggerated immune response.

Keywords

EN

acute respiratory distress syndrome; COVID-19; pathophysiology; pulmonary embolism; thromboembolism

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2022
• Issue: 2
• Pages: 212-216

Dates

published

2022

Contributors

author

Yethindra Vityala

• Department of Pathology, International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan

author

Abhijit Krishna

• International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan

author

Dinesh Pandla

• International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan

author

Krishna Priya Kanteti

• Beihua University, Jilin, China

author

Jahnavi Sadhu

• Apollo College of Physiotherapy, Telangana, India

author

HarshaVardhan Boddeti

• International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan

author

Tejesh Kintali

• International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan

author

Mohammad Shaour Khalid

• International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan

Identifiers

Biblioteka Nauki

2075063