Inflammatory bowel disease: the function of metalloproteinases

• Authors: Grzegorz Pasternak , David Aebisher , Rafał Filip , Dorota Bartusik-Aebisher
• Languages of publication: EN

Abstracts

EN

Introduction. Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Aim. The aim of this work was to review the current literature regarding matrix metalloproteinases. The databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles. Materials and methods. An analysis of literature. We collected information, data, and examples of the function of metalloproteinases. Results. Herein we show that metalloproteinases play a role in such processes as the immune response, angiogenesis, the epithelial barrier function, fibrosis induced by the inflammatory process, and in the process of carcinogenesis. Conclusions. Further studies on the role of metalloproteinases in the process of carcinogenesis associated with inflammatory bowel diseases are required.

Keywords

EN

inflammatory bowel disease; matrix metalloproteinases extracellular matrix

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2018
• Issue: 4
• Pages: 346-349

Contributors

author

Grzegorz Pasternak

• Clinical Department of General Surgery, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

author

David Aebisher

• Department of Photomedicine and Physical Chemistry, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

author

Rafał Filip

• Department of Gastroenterology, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

author

Dorota Bartusik-Aebisher

• Department of Biochemistry and General Chemistry, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland

Identifiers

DOI

10.15584/ejcem.2018.4.13