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Protective effect of sweet grass and black berries beverages on ethanol-induced disturbances in brain fatty acids

100%
Cyuńczyk M., Jarocka I., Hodun T., Hermanowicz J.
Progress in Health Sciences
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2012
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vol. 2
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issue 2
130-139
EN
Purpose: To investigate influence of sweet grass and blackcurrant beverages on the level of free as well as phospholipid fatty acids and MDA - lipid peroxidation product in the brain of rats intoxicated with ethanol (28 days). Materials and methods: Fatty acids profile in the rat brain was determined by gas chromatography while MDA level was examined by HPLC. Results: Alcohol intoxication contributed to increase in the level of the most of free as well as phospholipid fatty acids (saturated and unsaturated). The above changes are accompanied by a significant increase in the lipid peroxidation product – MDA. Similarly, drinking the sweet grass beverage as well as black currant juice leads to an increase in the level of the most of free as well as phospholipid fatty acids [saturated and unsaturated] while the increase after drinking of the black currant juice was higher than after sweet grass. Intoxication of rats drinking both natural beverages causes diminution of all fatty acids level while changes after black currant juice are more significant than after sweet grass. The level of MDA in the brain of rats intoxicated with ethanol and drinking natural beverages is lower than in the ethanol group. Conclusions: Beverages of sweet grass and to a higher degree black berries partially prevent distur-bances in the brain fatty acids level and protects lipids against peroxidation caused by chronic ethanol intoxication.
2

Advanced glycation end products in the plasma and renal tissues in experimental model of unilateral renal artery stenosis

88%
Brańska J., Kruszewski K., Jarocka I., Tarasik A., Ostrowska H.
Progress in Health Sciences
|
2012
|
vol. 2
|
issue 2
125-129
EN
Purpose: To evaluate whether advanced glycation end products (AGE) levels are increased in the plasma and renal tissues of rats after unilateral renal artery stenosis (RAS). Materials and methods: AGE levels were measured using commercially available ELISA kit in plasma and renal tissue samples obtained from 16 rats with experimental induced RAS for 3 and 28 days and from 6 respective sham-operated control rats. We also analyzed by HPLC the concentration of 4-hydroxynonenal (4-HNE), a known inducer of AGE formation and accumulation. Results: Plasma concentrations of 4-HNE and AGE were significantly increased (p<0.05) after 28 days of RAS. At this time point, the concentration of AGE was markedly increased in the clipped atrophic kidney (by about 10-fold; p<0.05), but it was unchanged in the contralateral kidney of the same rats. No differences in plasma and renal AGE levels were detected at day 3 of RAS. Sham operation did not affect the levels of AGE and 4-HNE at each time point. Conclusions: Increased accumulation of AGE both in the plasma and in the ischemic atrophic kidney suggest that AGE levels can be used as a reliable biomarker for monitoring the development of ischemic nephropathy caused by renal artery stenosis.
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