Results found: 1

Search results

Sort By:

Limit search:

Heritability and Genetic Relationship of Adult Self-Reported Stuttering, Cluttering and Childhood Speech-Language Disorders

100%

Fagnani C., Fibiger S., Skytthe A., Hjelmborg J. v. B.

Logopedia

2009

vol. 38

71-100

Genetic influence and mutual genetic relationship for adult self-reported childhood speech-language disorders, stuttering, and cluttering were studied. Using nationwide questionnaire answers from 34,944 adult Danish twins, a multivariate biometric analysis based on the liability-threshold model was performed in order to estimate heritability of the traits and genetic correlation between them. The lifetime prevalence rates were in agreement with previous reports, and were higher for males than for females for all three traits. The probandwise concordance rates were always substantially higher for monozygotic compared to dizygotic pairs, suggesting genetic influence. Multivariate biometric analyses showed that additive genetic and unique environmental factors best explained the observed concordance patterns. Heritability estimates for males/females were 0.71/0.87 for childhood speech-language disorders, 0.78/0.80 for stuttering, and 0.53/0.65 for cluttering. For each trait, the same genes were suggested to affect liability in males and females. Furthermore, high genetic correlations between the traits were obtained; the estimates for childhood speech-language disorders and stuttering were 0.71/0.79 for males/females, for childhood speech-language disorders and cluttering 0.73/0.56, and for stuttering and cluttering 0.53/0.57. Substantial unique environmental correlations between the traits were also found in both genders. Conclusion: With the limitations related to self-reporting from adult age, this study demonstrates substantial genetic influence on the traits of childhood speech-language disorders, stuttering, and cluttering, and mutual genetic relationship between them.

Celem pracy było zbadanie wzajemnego związku między jąkaniem, giełkotem i rozwojowych zaburzeniami mowy i języka na poziomie genetycznym u dorosłych poprzez zadawanie pytań jednozadaniowych (single-item). Zamiarem było potwierdzenie, czy te pytania zgodne są z wynikami przesiewowych bądź diagnozowanych danych wejściowych. Jeśliby stwierdzono zgodność, autorzy chcieliby rozszerzyć model biometryczny o nowy aspekt związku między tymi trzema cechami rozwojowych zaburzeń komunikacji ustnej.

Refine search results

1 Logopedia

1 Fagnani C.

1 Fibiger S.

1 Hjelmborg J. v. B.

1 Skytthe A.

1 2009

Search results

Heritability and Genetic Relationship of Adult Self-Reported Stuttering, Cluttering and Childhood Speech-Language Disorders