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Inflammatory and oxidative status in neurogenic bladder children after meningomyelocele

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Korzeniecka–Kozerska, A, Liszewska A.
Progress in Health Sciences
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2015
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vol. 5
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issue 1
22-28
EN
Introduction: Neurogenic bladder (NB) most often is caused by meningomyelocele (MMC) and manifests with various lower urinary tract dysfunctions. Condition of NB is worsened by inflammatory process or oxidative status imbalance. Purpose: To estimate of urinary uric acid (UA), hs-CRP, thiol status in association with NB function in MMC patients.Materials/Methods: 33 MMC children and 20 healthy individuals were included into the study. The first daytime urine samples were collected from all examined participants and urinary thiol status, hs CRP and UA were measured.Results: MMC children presented higher urinary UA level. The median hs-CRP level were also higher in MMC patients compared to the reference. Thiol status were lower in MMC individuals compared to reference group. We found positive correlation between serum creatinine, serum UA and urine creatinine and negative between serum creatinine and GFR. Correlations between urinary UA and physical development parameters, renal function, hsCRP, thiol status and urodynamic findings in MMC and reference groups were found.Conclusions: UA is a marker potentially having direct effect on the bladder function. Disturbed oxidative status and increased markers of inflammation may be a potentially modifiable factors affecting function of lower urinary tract in MMC children.
2
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Folate and homocysteine status in children with neurogenic bladder due to meningomyelocele

81%
Korzeniecka–Kozerska, A, Okurowska-Zawada B., Bagińska J.
Progress in Health Sciences
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2014
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vol. 4
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issue 2
37-44
EN
Introduction: Meningomyelocele (MMC) is the most severe form of spina bifida caused by both genetic and environmental components. It is well known that status of folate plays an important role in the risk of neural tube defects. High homocysteine (Hc) level may be associated with disturbed sensory and motor peripheral nerve function and is lowering after folic acid (FA) fortification. Purpose: To explore possible links of FA (folic acid) and Hc (Homocysteine) and to correlate them with renal and bladder function (based on urodynamics) as well as physical activity in patients with NB (neurogenic bladder) after MMC (myelomeningocele). Materials and methods: The investigation was conducted on two groups: group 1- 30 children with neurogenic bladder, group 2 - 20 healthy children with no abnormalities in urinary and nervous systems. The Hc concentration in urine and serum was estimated using the ELISA set and FA was measured in serum using electro-chemiluminescence method. FA/Hc ratio was calculated in all children. Results: The median serum and urine Hc were higher compared with reference group. Median FA/Hc ratio was statistically significantly lower in MMC group compared to reference group. There were no differences in serum FA between studied groups. We found statistically significant correlations between urodynamics parameters and FA and Hc. Conclusions: Hyperhomocyteinemia and hyper-homocysteinuria could be considered as factors influencing bladder function in MMC patients. Although serum FA level was in normal range in MMC patients it does not exclude disturbed folic acid status.
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Safety and efficacy of granulocyte colony stimulating factor in a patient with tetraplegia caused by cervical hyperextension injury: a case report

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Okurowska-Zawada B., Kułak W., Sienkiewicz D., Paszko-Patej G., Dmitruk E., Kalinowska A., Wojtkowski J., Korzeniecka–Kozerska, A
Progress in Health Sciences
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2014
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vol. 4
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issue 2
181-184
EN
he authors present the case of a 17-year-old boy who suffered a cervical spinal injury as a result of the sharp bending of the head after slipping (without falling). After about 30 minutes, he began to feel tingling in the limbs and he developed tetraparesis. He went through physical rehabili-tation, psychological rehabilitation, occupational therapy, and periodic catheterization. Additionally, we introduced to him a low dose of analog granulocyte colony-stimulating factor (G-CSF). G-CSF 5 μg/kg was given subcutaneously daily for 5 days per month for 3 months, again after 6 months, and again after 10 months. The boy could sit indecently and walk with assistance. A significant increase in muscle strength in this patient with tetraplegia after 10 months of treatment may indicate beneficial effects of G-CSF in this disorder.
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