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1

EXPLORATORY DATA ANALYSIS FOR THE HEMATOLOGICAL FEATURES. PART I. METHODOLOGY

100%
Cwiklinska-Jurkowska M.
Studies in Logic, Grammar and Rhetoric
|
2010
|
issue 21(34)
47-59
EN
Part I of the work characterizes the data of human blood parameters. It describes examined biomedical data set and used multivariate statistical exploratory methods like PCA, FA, MDS and clusters analysis. To the factor analysis methods belongs the biplots visualization method. Biplots are simply the scatterplots with the superimposition of the variables. The work compares different other alternative multivariate exploratory data analysis procedures from methodological point of view. The described multivariate ordination methods are applied in the Part II of the work 'Application'.
2

EXPLORATORY DATA ANALYSIS FOR THE HEMATOLOGICAL FEATURES. PART II. APPLICATION

100%
Cwiklinska-Jurkowska M.
Studies in Logic, Grammar and Rhetoric
|
2010
|
issue 21(34)
61-80
EN
Part II contains numerical and graphical exploratory analysis results and elements of their medical interpretation for the set of the hematological observations and hematological variables. On the basis of correlation matices, matrix of scatterplots with overlaid regression lines and two and three-dimensional biplots relationships between parameters of blood during hemoperfusion is examined. For comparison purposes also MDS and one-way and two-way cluster analysis are performed. Usefulness of applied methods of multivariate data ordination to inspect, e.g. variables' interdependencies was assessed. Applied methods gave very close results and the medical interpretation of the results confirm some physiological clotting ideas. The practical results confirm some hypothesis describing polymer-blood interactions. Additionally, the results of principal factor analysis and multidimensional metric scaling with cluster analysis are concordant. The variety of applied exploration data methods confirm results and give the possibility of looking at data from different point of views.
3

PERFORMANCE OF CLASSIFICATION METHODS FOR DIFFERENTIATION BETWEEN CIRRHOTIC TISSUES AND CIRRHOTIC TISSUEWITH CONCOMITANT HEPATOCELULAR CARCINOMA. CLASSIFICATION OF LIVER TISSUES

63%
Wietlicka-Piszcz M., Cwiklinska-Jurkowska M.
Studies in Logic, Grammar and Rhetoric
|
2010
|
issue 21(34)
91-105
EN
This paper presents the comparison of various discriminant methods for differentiation between cirrhotic tissue and cirrhotic tissue with concomitant hepatocelular carcinoma on the basis of oligonucleotide microarray dataset. Four methods of dimensionality reduction by selection of features (genes) subsets: linear models with empirical Bayes methods [Smyth 2004], SAM, PAM and Wilcoxon statistic were implemented. For studied subsets of genes ranked by these methods the performance of seven discriminant procedures was estimated by test error, 10-fold CV and bootstrap 0.632 with 95% confidence intervals. The best performance was obtained for SVM, bootstrap aggregating trees as well as adaptive boosting trees.
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