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EN
School evaluation and self evaluation are concerned with the control of both the process and end product. Control of the process dictates the content and the methodology of teaching and learning and extends it to it's maximum boundaries. On the other hand, control of the results of teaching and learning allows the expected outputs to be achieved in a discretionary manner with a minimal drawing of limits. In each case diagnosis forms the bases for action. The choice of what is to be diagnosed is similar to the choice of direction of change. This being the case it follows that every school evaluation should be preceded by a meta-evaluation of the prejudices and 'weltanchauung' of the evaluation and change planners themselves. Every school should strive to be different from others; possess its own unique identity and through self evaluation consciously form its individuality.
EN
Purpose: To evaluate whether advanced glycation end products (AGE) levels are increased in the plasma and renal tissues of rats after unilateral renal artery stenosis (RAS). Materials and methods: AGE levels were measured using commercially available ELISA kit in plasma and renal tissue samples obtained from 16 rats with experimental induced RAS for 3 and 28 days and from 6 respective sham-operated control rats. We also analyzed by HPLC the concentration of 4-hydroxynonenal (4-HNE), a known inducer of AGE formation and accumulation. Results: Plasma concentrations of 4-HNE and AGE were significantly increased (p<0.05) after 28 days of RAS. At this time point, the concentration of AGE was markedly increased in the clipped atrophic kidney (by about 10-fold; p<0.05), but it was unchanged in the contralateral kidney of the same rats. No differences in plasma and renal AGE levels were detected at day 3 of RAS. Sham operation did not affect the levels of AGE and 4-HNE at each time point. Conclusions: Increased accumulation of AGE both in the plasma and in the ischemic atrophic kidney suggest that AGE levels can be used as a reliable biomarker for monitoring the development of ischemic nephropathy caused by renal artery stenosis.
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