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1

Progressive paraparesis in 14 - year-old male with kyphoscoliosis: A case report

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Okurowska-Zawada B., Kułak W., Sienkiewicz D., Paszko-Patej G.
Progress in Health Sciences
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2012
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vol. 2
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issue 2
203-206
EN
A 14-year-old male presented with congenital kyphoscoliosis along with progressive paraparesis. Radiographs confirmed kyphoscoliosis and magnetic resonance imaging revealed a stretched and flattened spinal cord over the kyphotic deformity and a T6 hemivertebra. Before the surgical treatment the patient had clinical signs and symptoms of paraparesis. A gradual deterioration in the neurologic status was observed and patient became paraplegic after the surgery. Currently, the patient moves in a wheelchair, has a pyramidal syndrome of the lower limbs and neurogenic bladder.
2

Neurologic adverse events following vaccination

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Sienkiewicz D., Kułak W., Okurowska-Zawada B., Paszko-Patej G.
Progress in Health Sciences
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2012
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vol. 2
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issue 1
129-141
EN
The present review summarizes data on neurological adverse events following vaccination in the relation to intensity, time of onset, taking into account the immunological and non-immunological mechanisms. The authors described the physio-logical development of the immune system and the possible immune system responses following vaccination. Toxic property of thimerosal - a mercury-containing preservative used in some vaccines was presented. The neurological compli-cations after vaccination were described. The role of vaccination in the natural course of infectious diseases and the current immunizations schedule in Poland was discussed.
3

Asymptomatic hepatic echinococcosis. A case report

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Gościk E., Kułak P., Okurowska-Zawada B.
Progress in Health Sciences
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2013
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vol. 3
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issue 2
183-186
EN
Echinococcosis, is a parasitic disease of tapeworms in the genus Echinococcus. We report an unusual case of a 17-year-old girl with asymptomatic hepatic echinococcosis. The patient was admitted to the hospital after a car accident to perform routine radiological exams. Abdominal ultrasonography revealed a cystic mass of size 65 × 52 mm in the right lobe of liver. Computed tomography (CT) confirmed the cystic mass of size 67 mm x 59 mm x 56 mm in the right lobe of the liver. A routine brain CT was normal. Laboratory tests revealed a high count of eosinophil count (6.9%). Serological tests confirmed Echinococcus granulosus. The patient was transferred to the department of infectious diseases for further treatment.
4

Cell therapy: a new hope for treatment of cerebral palsy ?

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Kułak W., Okurowska-Zawada B., Sienkiewicz D., Paszko-Patej G.
Progress in Health Sciences
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2012
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vol. 2
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issue 2
174-180
EN
Cerebral palsy (CP) is the most frequent neurological disorder associated with perinatal injury of the developing brain. The beneficial impact of stem cells (neural stem cells, mesenchymal stem cells, and embryonic stem cells) is mediated through soluble trophic factors and other cytokines that enable the body to re-establish homeostasis after pathologic and traumatic insults, inflammation, and tissue infarction or degeneration. There is currently no effective therapy for CP. Recently there have been notable advances in the application of cell therapy in neurological disorders. This review provides recent data on the prevention and cell therapy in CP.
5
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Folate and homocysteine status in children with neurogenic bladder due to meningomyelocele

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Korzeniecka–Kozerska, A, Okurowska-Zawada B., Bagińska J.
Progress in Health Sciences
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2014
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vol. 4
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issue 2
37-44
EN
Introduction: Meningomyelocele (MMC) is the most severe form of spina bifida caused by both genetic and environmental components. It is well known that status of folate plays an important role in the risk of neural tube defects. High homocysteine (Hc) level may be associated with disturbed sensory and motor peripheral nerve function and is lowering after folic acid (FA) fortification. Purpose: To explore possible links of FA (folic acid) and Hc (Homocysteine) and to correlate them with renal and bladder function (based on urodynamics) as well as physical activity in patients with NB (neurogenic bladder) after MMC (myelomeningocele). Materials and methods: The investigation was conducted on two groups: group 1- 30 children with neurogenic bladder, group 2 - 20 healthy children with no abnormalities in urinary and nervous systems. The Hc concentration in urine and serum was estimated using the ELISA set and FA was measured in serum using electro-chemiluminescence method. FA/Hc ratio was calculated in all children. Results: The median serum and urine Hc were higher compared with reference group. Median FA/Hc ratio was statistically significantly lower in MMC group compared to reference group. There were no differences in serum FA between studied groups. We found statistically significant correlations between urodynamics parameters and FA and Hc. Conclusions: Hyperhomocyteinemia and hyper-homocysteinuria could be considered as factors influencing bladder function in MMC patients. Although serum FA level was in normal range in MMC patients it does not exclude disturbed folic acid status.
6
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Granulocyte colony-stimulating factor potential use in the treatment of children with cerebral palsy

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Paszko-Patej G., Sienkiewicz D., Okurowska-Zawada B., Kułak W.
Progress in Health Sciences
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2017
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vol. 7(1)
187-192
EN
Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the blood. Recent studies demonstrated the presence of CSF-receptor (G-CSFR) system in the brain and spinal cord, and their roles in neuroprotection and neural tissue repair, as well as improvement in functional recovery. G-CSF exerts neuroprotective actions through the inhibition of apoptosis and inflammation, and the stimulation of neurogenesis. This review highlights recent studies on the potential use of G-CSF in cerebral palsy.
7

Volumetric magnetic resonance imaging of gastrocnemius muscle in a patient with facioscapulohumeral dystrophy

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Gościk E., Kułak P., Sienkiewicz D., Kułak W., Okurowska-Zawada B.
Progress in Health Sciences
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2013
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vol. 3
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issue 2
175-177
EN
Introduction: Magnetic resonance imaging (MRI) is a nonradiographic, non-invasive method to visualize and quantify muscle cross-sectional areas and volumes. Purpose: To evaluate a gastrocnemius muscle volume in a 15-year-old male with facioscapulo-humeral dystrophy (FSHD) using MRI. Material and methods: The patient with FSHD was given subcutaneously recombinant human granulocyte colony-stimulating factor - filgrastim (5μg/kg body/day) for 5 consecutive days during the first, second, and third months. The Siemens Magnetom 0.3T MRI scanner was used to acquire the images of the right calf of the patient. The analysis of MR images used advanced biomedical imaging software-Analyze 10 Biomedical Imaging Software. Results: The patient with FSHD after 6 month of the treatment compared with baseline had greater volume of the gastrocnemius muscle volume of the right calf. Muscle volume increased from 60,567.5 mm3 to 70,795.6 mm3. The increased of muscle volume of this patient correlated with the improvements of muscle strength and EMG. Conclusion: MR imaging can provide quantitative, reproducible volumetric measures of muscles in the patients with FSHD.
8

The cerebellum in children with spastic cerebral palsy: Volumetrics MRI study

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Gościk E., Kułak W., Gościk J., Okurowska-Zawada B., Tarasow E.
Progress in Health Sciences
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2011
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vol. 1
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issue 2
67-75
EN
Purpose: To determine the volume of the cerebellum in children with spastic cerebral palsy (CP) in relation to risk factors and motor development. Material and methods: The present study included 30 children with spastic CP, aged 2-17 years. The volume of the cerebellum was examined on sagittal magnetic resonance images (MRI) of the CP patients and on 33 healthy subjects. To estimate the total cerebellum volume of each subject we used Analyze 10 Biomedical Imaging Software. Results: Children with spastic CP (129726,2 ± 26040,72 mm3) had a significantly smaller mean of the cerebellum volume compared to controls (143122,5 ± 12351,10 mm3). No significant difference between the total cerebellar volume and gender in patients with CP was found. No significant relationship between cerebellar volume and birth weight, Apgar score, gestational age, and Gross Motor Function Classification System (GMFCS) level were noted. Positive correlations between birth weight, Apgar score, gestational age, and GMFCS level, between Apgar score and gestational age, or between gestational age and GMFCS level were found. Conclusion: Our results show that children with spastic CP had smaller volumes of the cerebellum as compared to controls.
9

Polish and Belaursian students’ attitudes toward other nations

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Krajewska-Kułak E., Kułak W., Okurowska-Zawada B., Kułak A., Shpakau A.
Progress in Health Sciences
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2012
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vol. 2
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issue 2
29-42
EN
Introduction: Approximately 7,000 different ethnic groups and nations inhabit the earth, and most of the tensions among people stem from prejudice and intolerance. Purpose: To assess a student perception of foreign nations and cultures. Materials and methods: We used the original questionnaire to assess the views of 150 students from Poland and 102 students from Belarus. Results: Twenty percent of the Polish respondents indicated that Poland is a tolerant nation; in contrast, 70.6% of Belarusian students claim that theirs is a tolerant nation. Almost 57% of the Polish and 34.3% of the Belarusian students knew a person belonging to a national or ethnic minority. 37.4% of the Polish respondents and 12.7% of the Belarusians were convinced that tolerance among foreign nations has increased. Neither the Polish nor the Belarusian students wanted to have as a neighbor, partner or spouse, a colleague at school who was a drug addict, homosexual or HIV positive. Nearly 40% of the Polish and 77.5% of the Belarusian respondents indicated that national minorities could have the opportunity to learn their language by accessing extra lessons offered at school. Fifty-eight percent from Poland and 52.9% from Belarus were opposed to providing financial assistance to support foreign cultures and traditions, and the same number believed that foreign students could communicate in their language in local offices. The Polish students’ most positive features were attributed to the Italian, French, and Greek, whereas the Belarusian students held the British, Finnish and French in the highest esteem. The Polish respondent's most negative features were attributed to Gypsies and Russians, and the Belarusian students had the lowest esteem for the Germans, Arabs and Chechens. Conclusions: Poles are not tolerant nation, but their acceptance is increasing. Belarusians are tolerant, but their acceptance is declining. We found differences in the positive and negative perceptions of other nations depending on the nationality
10

An unusual case of burst cervical spinal fracture of a 15-year-old boy complicated by venous thrombosis and neurogenic heterotopic ossification

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Sienkiewicz D., Kułak W., Gościk E., Okurowska-Zawada B., Paszko-Patej G.
Progress in Health Sciences
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2011
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vol. 1
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issue 2
192-195
EN
The authors report an unusual case of a 15-year-old boy who dove into a shallow lake and suffered a cervical fracture of C5 affecting the spinal cord. This resulted in tetraplegia. Vitamin D3 deficiency and a history of several bone fractures supported an idea that the patient's bone structure had been weakened. The deep vein thrombosis of lower limb and neurogenic heterotopic ossification of a hip limited the effectiveness of physical therapy.
11
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Safety and efficacy of granulocyte colony stimulating factor in a patient with tetraplegia caused by cervical hyperextension injury: a case report

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Okurowska-Zawada B., Kułak W., Sienkiewicz D., Paszko-Patej G., Dmitruk E., Kalinowska A., Wojtkowski J., Korzeniecka–Kozerska, A
Progress in Health Sciences
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2014
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vol. 4
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issue 2
181-184
EN
he authors present the case of a 17-year-old boy who suffered a cervical spinal injury as a result of the sharp bending of the head after slipping (without falling). After about 30 minutes, he began to feel tingling in the limbs and he developed tetraparesis. He went through physical rehabili-tation, psychological rehabilitation, occupational therapy, and periodic catheterization. Additionally, we introduced to him a low dose of analog granulocyte colony-stimulating factor (G-CSF). G-CSF 5 μg/kg was given subcutaneously daily for 5 days per month for 3 months, again after 6 months, and again after 10 months. The boy could sit indecently and walk with assistance. A significant increase in muscle strength in this patient with tetraplegia after 10 months of treatment may indicate beneficial effects of G-CSF in this disorder.
12
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Quality of life of children suffering from motor disabilities as evaluated by their parents

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Wojtkowski J., Sienkiewicz D., Okurowska-Zawada B., Paszko-Patej G., Konopka A., Okulczyk K., Średzińska K., Dmitruk E., Mirska A., Kułak W.
Progress in Health Sciences
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2017
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vol. 7(2)
60-66
EN
Purpose: We assessed the quality of life of children with motor disabilities in comparison with healthy children, as evaluated by their parents, using the CHQ-PF28 questionnaire (Child Health Questionnaire—Parent Form). Materials and methods: In a prospective study, we evaluated the quality of life of 105 children with motor disabilities. Results: Our research showed lower quality of life in the group of children with motor disabilities compared with controls, both in terms of physical and psychosocial health. Significant correlations between independent walking and physical functioning, general behavior, and mental health of children suffering from motor disabilities were found. According to the average indices of quality of life of children suffering from motor disabilities, depending on sex, the greatest differences occurred in behavior and change of health status, while the smallest differences in self-esteem and parental involvement, compared with controls. In the case of healthy children, the largest differences appeared in the perception of pain, behavior, and self-esteem; whereas, the smallest variations occurred in the change of health status and physical activity. Conclusion: Children suffering from motor disabilities demonstrate lower quality of life compared with healthy children.
13
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Effects of short moderate exercise on hematological parameters and stem cells in healthy humans

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Sochoń K., Sienkiewicz D., Okurowska-Zawada B., Paszko-Patej G., Wojtkowski J., Dmitruk E., Żak J., Kułak W.
Progress in Health Sciences
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2016
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vol. 6(2)
184-187
EN
Introduction: Exercise at various durations and intensities impact on blood and stem cells. This pilot study examined the effects of 30 minutes of treadmill walking on hematological indices and progenitor stem cells CD34+ in healthy subjects. Materials and methods: A total of 17 non-smoking, healthy students, aged 20 to 22 years participated. Hemoglobin, hematocrit, white blood cells, platelets, and stem cell CD34+ numbers were assessed before and after moderate exercise. Statistical analyses examined the relationships between CD34+ cells versus hematological indices, age, and body mass index. Results: Following exercise, significant increases were observed in leukocytes, neutrophils, eosinophils, and CD34+ cells numbers. For CD34+ cells, a fourfold increase was seen. Significant correlations between CD34+ cells, white blood cells, and neutrophils were found. Conclusion: Our results suggest that moderate exercise has a physiological impact on hematologic parameters and stem cells CD34+ in healthy subjects. Furthermore, our findings suggest that brief treadmill exercise may enhance tissue repair mechanisms so important in physiotherapy.
14
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Effects of granulocyte colony-stimulating factor therapy for osteogenesis imperfecta: a case report

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Paszko-Patej G., Sienkiewicz D., Kułak W., Okurowska-Zawada B., Wojtkowski J., Kalinowska A., Okulczyk K., Sochoń K., Dmitruk E., Mirska A.
Progress in Health Sciences
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2017
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vol. 7(1)
205-208
EN
Introduction: Osteogenesis imperfecta (OI) is a genetic disorder of increased bone fragility and low bone mass. OI type IV. Materials and methods: We examined the safety and effectiveness of a low dose of analog granulocyte colony-stimulating factor (G-CSF) in a 15-year-old girl OI type IV. G-CSF 5 μg/kg was given subcutaneously, for 5 days/month for 3, 6 and 12 months. Laboratory tests, including blood, biochemical tests were performed, in addition to clinical examination.Results: Clinical examination revealed an increase of muscle strength in the upper and lower limbs between base line and day 6 and 12 months. We found no serious adverse events. Leukocyte levels remained below 38,000/μL. Low dose G-CSF was safe and well tolerated by the patient. Conclusions: A significant increase in muscle strength in this patient may indicate beneficial effects of G-CSF factor in this disorder. These results are inspiring and warrant further studies.
15
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Effects of granulocyte colony-stimulating factor treatment in children and patients with cerebral palsy: a preliminary report

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Paszko-Patej G., Kułak W., Okurowska-Zawada B., Sienkiewicz D., Wojtkowski J., Sochoń K., Kalinowska A., Okulczyk K., Topór E., Mirska A.
Progress in Health Sciences
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2017
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vol. 7(1)
78-82
EN
neuroinflammation and apoptosis in brains affected by cerebral palsy could be therapeutic targets. Granulocyte colony-stimulating factor (G-CSF) exerts anti-inflammatory and antiapoptosis effects and stimulates the proliferation of neural stem and progenitor cells in the brain. Purpose: To assess the efficacy and safety of G-CSF treatment in children and adolescents with CP. Materials and methods: Six patients with spastic tetraplegia CP aged 3-15 years were enrolled in this study. Five patients had GMFCS (Gross Motor Function Classification System) level at V, three children had epilepsy, and three had severe mental retardation. We used the gross motor function measure-66 (GMFM-66) to assess motor function.GCSF (5μg/kg/body/day) was administered subcutaneously for five consecutive days during the four months. The parents also evaluated the physical and mental development of their children. Results: We observed improvement in motor function in patients with CP on the GMFM-66 scale. Parents reported improvement in behavior, speech development, and a decrease in spasticity in children with CP. G-CSF therapy was well-tolerated. No side effects were observed during the study. Conclusions: Our preliminary report suggests that G-CSF treatment improves motor and mental function in patients with CP. Further studies are needed to confirm these observations
16
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Granulocyte colony-stimulating factor therapy for facioscapulohumeral dystrophy: a case report

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Sienkiewicz D., Kułak W., Okurowska-Zawada B., Paszko-Patej G., Wojtkowski J., Dmitruk E., Okulczyk K., Sochoń K., Kalinowska A., Żak J., Pogorzelski R.
Progress in Health Sciences
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2016
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vol. 6(2)
175-177
EN
We examined the safety and effectiveness of a low dose of analog granulocyte-colony stimulating factor in a 15-year-old boy with facioscapulohumeral dystrophy. The onset of disease was noted at 12 years of age. The physical examination noted general muscle atrophy more pronounced at left side of the body. He was able to walk 300 meters within 6 minute walk test. Granulocyte colony-stimulating factor 5 μg/kg was given subcutaneously daily for 5 days/month for 1, 2, 3, 6 and 12 months. Clinical examination, laboratory tests including blood, biochemical tests, and CD34+ cells were performed. A significant increase of muscle strength in the lower and upper limbs between baseline, and after 3 months of treatment, after 6, and after 12 months was found. He was able to walk 480 meters within 6 minutes after 12 months. Electromyography demonstrated increase of amplitude in the examined in upper and lower limbs after six months compared to baseline. Leukocyte levels remained below 25000/μL. CD34+ increased significantly at day 5 of granulocyte colony-stimulating factor admini-stration. It was safe and well tolerated by the patient. A significant increase in muscle strength in this patient with facioscapulohumeral dystrophy after 3 months of treatment, after 6, and after 12 months since the first treatment course was completed may indicate beneficial effects of granulocyte colony-stimulating factor in this disorder.
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