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Effect of a medicinal agent, possessing antioxidant and antihypoxant properties, on the state of oxygen homeostasis and lipid peroxidation under experimental pneumoconiosis in albino rats

100%
Olyinyk A., Ślifirczyk A., Nikoniuk M., Celiński M., Domańska, D>
Progress in Health Sciences
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2018
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vol. 8(2)
137-143
EN
Introduction: Pneumoconioses (Pc) are interstitial pulmonary diseases of professional genesis, caused by long-term inhalation of high dust concentrations. Pcafflict 26.6-53% of the workers, exposed to dust contamination. The major feature of Pc course is irrevocability and incurability. Purpose: The research of the effect of ethylmethyl hydroxypyridine succinate, possessing antioxidant and antihypoxant characteristics, on the oxygen metabolism, acid-alkaline state, and lipid peroxidation at the background of experimental pneumoconiosis in albino rats. Material and methods: Pneumoconiosis was simulated on 72 albino rats through endotracheal injection of black coal suspension, on our own modification of O. Yu. Nykolenko methodology. Results: Manifestations of experimental pneumo-coniosis depended on the period of dust inhalation. Development of experimental pneumoconiosis was found to result in the decreased partial oxygen pressure in the arterial blood, compensated hyperventilation-induced respiratory alkalosis, and marked increase in lipid peroxidation activity that could be seen in the blood content of malon-dialdehyde, as well as of conjugated dienes and trienes. Conclusions: Application of ethylmethylhydroxy pyridine succinate in experimental pneumoconiosis has been found to improve oxygen metabolism, acid-alkaline state, and lipid peroxidation that is revealed in normalization of the partial oxygen pressure in the arterial blood, oxygen saturation of haemoglobin, index of bases’ deficiency BE (Ваse-Ехсеss), and in 1.6-2.0 decrease in the content of malondialdehyde, as well as of conjugated dienes and trienes.
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Medical and legal aspects of Siamese twins` life

86%
Chomicz K., Ślifirczyk A., Ślifirczyk M., Celiński M., Bytys M., Domańska D., Nikoniuk M.
Progress in Health Sciences
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2018
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vol. 8(2)
229-233
EN
Siamese twins have always aroused a lot of emotions in the human world. It is related to the fact that they are simply conjoined to each other. Through their unnatural structure, they challenge not only medical or ethical boundaries, but also legal. Some even say that they pose a threat to rooted social values.
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Nursing care of a child with acute lymphoblastic leukemia

72%
Ślifirczyk A., Piszcz P., Ślifirczyk M., Michalczuk T., Urbańczuk M., Celiński M., Bytys M., Domańska D., Nikoniuk M.
Progress in Health Sciences
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2018
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vol. 8(2)
168-173
EN
Every year a very large number of children in the world suffer from acute lymphoblastic leukemia, and for years there has been a steady increase in the number of new cases. Acute lymphoblastic leukemia accounts for 75% of leukemia cases in the world. Lymphoblastic leukemia is a cancer disease that originates in B or T cell lymphocytes, which expansion takes place in blood and in the bone marrow. The etiology of the disease is not fully understood because it consists of several factors conditioning its formation. The most important element is the early detection and taking actions resulting in effective disease control through treatment and care of the patient. The nursing process should allow the patient to be involved in and accept the ongoing cancer process, and medical personnel, family and specialists in such fields as psychology and psychiatry should participate.
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