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Granular cell tumor of the neurohypophysis – a case report

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Rafał Dziedzic R., Natalia Leksa N., David Aebisher D., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2019
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issue 4
378-380
EN
Introduction. The granulomatous tumor (GCT) is formed from the posterior pituitary (neurohypophysis) or its pedicle. The location of such a tumor in the region of the Turkish or supra saddle is a very rare matter. Aim. To present a case report. Description of the case. This article describes the case of a 39-year-old man admitted to the Department of Neurosurgery with a MR-diagnosed head tumor in the suprasellar area growing out of the pituitary funnel. The tumor appeared to be an epileptic fit. Conclusion. Herein we described a clinical case of granulomatous tumor. GCTs in the pituitary nerves are benign tumors, which makes treatment dependent on the individual case. After the operation, the H-P study showed a granulomatous tumor (GCT) of the posterior pituitary gland.
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The role of MRI in the central nervous system

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Natalia Leksa N., David Aebisher D., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 1
28-31
EN
Introduction. Magnetic Resonance Imaging (MRI) has modified the practice of radiology. MRI is base on safe interaction between radiowaves at a particular frequency and hydrogen nuclei in the body. Metabolic encephalophaties are by definition those disorder of the central nervous system that are not due primarily to structural abnormalities. Aim. Here we present the 1 H MRI and functional MRI (fMRI) method applied to diagnosis of disorders of the central nervous system. Material and methods. Analysis of literature and self-research. Results.We have discussed the major MRI applications in the characteristic of the central nervous system. The relationship beteen the motion of flowing blood and the representation of the blood on images is complex. This work is an introduction to the basic ideas and techniques of fMRI. Therefore, both, 1 H MRI and functional MRI, methods are ued in neuroscience. Conclusion. Nonivasive MRI and functional MRI are daily diagnostics methods in neurology.
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Vascular surgery and an occurrence of stroke

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Natalia Leksa N., Adam Uryniak A., David Aebisher D., David Leksa D., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 3
233-235
EN
Introduction. The brain responds to metabolic disorders with a limited array of symptoms and signs. The brain has enormous needs in terms of substrate and blood flow. Aim. This paper presents a case report reporting episode of stroke. Description of the case. The incidence of cerebral vascular episodes in the form of strokes, transient episodes of cerebral ischemia is reported. Conclusion. The chemical constituency of the brain are generally quite different from those of other tissues. Stroke is a clinical syndrome characterized by sudden focal or generalized brain dysfunction
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Fibromuscular dysplasia – a case description

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Natalia Leksa N., Bartosz Seweryn B., Dominika Uberman-Kluz D., Sabina Galiniak S., Magdalena Kawalec M.
European Journal of Clinical and Experimental Medicine
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2018
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issue 1
63-67
EN
Introduction. Fibromuscular dysplasia is an idiopathic, non-inflammatory and non-atherosclerotic disease that affects the walls of arteries (mostly renal and carotid arteries). Histological classification distinguishes three main types of the disease, depending on the structural changes occurring in one of the three layers of arterial vessel walls. Objective. We present here a case of fibromuscular dysplasia affecting the internal carotid arteries. Case description. This article describes the case of a 52-year-old female patient with hypertension, hyperlipidemia, and a cardiac pacemaker in whom computed tomography angiography revealed a narrowing of the internal carotid arteries without atherosclerotic symptoms. We describe the diagnostic methods and various types of treatment that the patient suffering from fibromuscular dysplasia was subjected to. Conclusions. Due to a low detection rate of fibromuscular dysplasia, if the disease is suspected, all available diagnostic methods should be employed. Taking into account the unknown etiology of the disease, it is not possible to use a preventive therapy, or a therapy focused on stalling the progression of the disease
5
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Sciatic vessels – a case report

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Łukasz Gałuszka Ł., Natalia Leksa N., Dawid Leksa D., Adam Uryniak A., David Aebisher D., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 4
326-327
EN
Introduction. Sciatic vessels most often accompany the sciatic nerve. Sciatic vessels are very rare. Aim. In this paper we determine the procedure in sciatic vessels surgical treatment. Description of the case. We present the case of a 75-year-old patient with symptoms of acute right lower limb ischemia. The patient was discharged home in good condition, and remains in outpatient control to this day. Conclusion. The popliteal artery proved to be available, but much deeper than usual.
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An iliac artery aneurysm

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Natalia Leksa N., Dawid Leksa D., Łukasz Gałuszka Ł., Adam Uryniak A., David Aebisher D., Sabina Galiniak S., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 3
242-244
EN
Introduction. Isolated common iliac artery aneurysms (CIAs) are rare. The rarer are rupture of the common iliac artery. We can treat them surgically: classic or endovascular. Open surgery has a main role in the management of aneurysms not suitable for repair by endovascular techniques. Aim. The aim of the study is to present the possibility of occurrence of such a disease at a young age, to indicate non-characteristic symptoms that may predict the above-mentioned disease entity at the level of a primary care physician or SOR. Review of medical publications from 2000-2019 regarding guidelines or methods of conduct in that cases. Description of the case. A patient 39 years old, admitted to the Department of Vascular Surgery, in an interview: about 15 years ago severely beaten, as a result of injuries total loss of hearing, memory and basic skills such as: speech, writing, reading, hospitalized over 6 months. Conclusion. Good rehabilitation and patient persistence restored cognitive skills. Advances in surgical has lowered the mortality and morbidity rates even in patients.
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Generation of retractive spine circuits in the process of vitamin B12 deficiency

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Patrycja Mucha P., Natalia Leksa N., David Aebisher D., Sabina Galiniak S., Seweryn Bartosz S., Dawid Leksa D., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 2
131-134
EN
Introduction. Subacute degeneration of the posterior and lateral spinal cord is a rare neurological complication of B12 avitaminosis. Aim. In this paper, we present the case of a 65-year-old man who, in the course of long-term vitamin B12 deficiency associated with atrophic gastritis, developed a severe set of neurological symptoms that are part of the retinal spinal cord degeneration with characteristic features in MR imaging of the cervical spine in the form of an inverted “V mark” ‘in axial images and typical localization in the spinal cord. Description of the case. After careful analysis of the syndrome and making an early diagnosis, parenteral vitamin B12 supplementation began, resulting in improved neurological status, laboratory parameters as well as regression of changes in magnetic resonance imaging. Conclusion Significant symptoms of this syndrome are paresthesia in the distal parts of the limbs, ataxia, spastic paresis.
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Clinical aspects of protein glycation

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Sabina Galiniak S., Izabela Krawczyk-Marć I., Anna Sęk-Mastej A., Natalia Leksa N., Marek Biesiadecki M., Stanisław Orkisz S.
European Journal of Clinical and Experimental Medicine
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2017
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issue 3
263-267
EN
Introduction. Glycation is a post-translational modification of proteins that depends on the non-enzymatic linkage of a ketone or aldehyde group of sugar with a free amino group of protein. Pathological effects of this process are observed in many disease states under conditions of hyperglycemia, in diabetic complications, and neurodegenerative diseases such as multiple sclerosis. Aim. In this paper we present the characteristics of the glycation process, its consequences, as well as a review of current knowledge about the role of glycation in multiple sclerosis. Material and methods. The databases EBSCO, PubMed, ScienceDirect and SpringerLink were used to search the literature. Analysis of the literature. Intermediate glycation products form a number of derivatives that contribute to oxidative stress and structural changes in the proteins, including induction of aggregation or reduction of affinity for drug proteins. Glucose products may contribute to neurodegenerative changes in patients with multiple sclerosis. Determination of protein glycation products can be successfully used to evaluate the course of multiple sclerosis as a diagnostic marker.
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Diagnostic and therapeutic difficulties of tick-borne encephalitis – a two case reports

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Dominika Przetacznik D., Natalia Leksa N., David Aebisher D., Sabina Galiniak S., Seweryn Bartosz S., Dawid Leksa D., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 2
135-140
EN
Introduction. The paper presents epidemiology, routes of infection, forms of the disease, diagnostic and treatment methods, and prophylaxis of tick-borne encephalitis. Aim. In this paper, we present two descriptions of the cases of tick-borne encephalitis. Description of the cases. Case 1. A 60-year-old man with fever up to 39 degrees for 3 days, multi-site headache and other body aches, as well as an earstuck feeling. The day before hospitalization, there was a feeling of numbness on the right side of the face from eye level to the chin and speech distortion. Case 2. A 60-year-old patient with headaches and an increase in temperature to 39 degrees for 3 days, who, approximately, three weeks earlier was ticked by a tick in the lower parts of the back. Conclusion. It is also important for doctors to take a broader view and to make society aware of that Lyme disease is not associated only with Lyme disease. Further work is also needed towards effective treatments for Tick-borne encephalitis (TBE).
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Stroke masks – a case report

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Beata Chmielewska B., Natalia Leksa N., David Aebisher D., Sabina Galiniak S., Dawid Leksa D., Seweryn Bartosz S., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 3
245-249
EN
Introduction. Stroke is a common vascular disease encountered in the work of a practitioner. Despite this, his differentiation is difficult. This is due to a variety of diseases that can be a “mask” for stroke. These are neurological diseases other than vascular (brain tumors, epilepsy), head injuries and a number of metabolic disorders (fluctuations in glucose, electrolytes). Aim. This work aims to approximate the differentiation of this common disease entity. Case reports show both clinical view and diagnostic difficulties. Description of the cases. Case 1. The patient 59 years old treated for bipolar disorder, hypertension and alcohol abuse. Case 2. The patient 68 years old treated for type 2 diabetes, hypertension, ischemic heart disease, cholecystolithiasis – cholecystectomy. Conclusion. Stroke is a significant clinical and social problem both in Poland and in the world. Despite this, its diagnostics and especially differentiation is difficult. When analyzing the case of each patient with suspected sudden CNS vascular disease, all of them should be remembered. It should also be borne in mind that differential diagnosis cannot delay specific treatment for stroke
11
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Rapidly progressing dementia as a manifestation of the Creutzfeldt-Jakob disease: an analysis of two cases

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Seweryn Bartosz S., Natalia Leksa N., Dominika Uberman-Kluz D., Artur Szymczak A., Marek Biesiadecki M., Sabina Galiniak S.
European Journal of Clinical and Experimental Medicine
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2019
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issue 1
89-93
EN
Introduction. Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disease of the central nervous system which is caused by an infectious protein called prion. Multiple forms of CJD have been classified including sporadic (more than 90% cases), familial, iatrogenic and variant type of disease. CJD, especially in its early stages, is a highly challenging illness to diagnose. Aim. Article aims to present cases of Creutzfeldt-Jackob disease with early symptoms of rapidly progressing dementia at the initial stage of CJD. Description of the cases. This paper describes two cases of patients with suspected CJD with a history of rapidly progressive dementia admitted to the Department of Neurology, MSWiA Hospital in Rzeszów. Conclusion. Despite the fact that CJD is an incurable illness and there is no cure guaranteeing recovery, it is important to make the right diagnosis. Assay of 14-3-3 protein in cerebrospinal fluid is a sensitive and specific marker which is helpful in the diagnosis of CJD. The only relevant method of correctly confirming a diagnosis of this disease is by performing a brain biopsy.
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Adrenomyeloneuropathy – a case report

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Natalia Leksa N., David Aebisher D., Sabina Galiniak S., Dominika Uberman-Kluz D., Serweryn Bartosz S., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2019
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issue 3
274-276
EN
Introduction. Adrenoleukodystrophy is a genetic disorder linked to the X chromosome, in which the peroxisomal beta-oxidation process is disturbed. It is a metabolic disease that results in the accumulation of very long chain fatty acids (VLCFAs - very long chain fatty acids) responsible for the symptoms of damage to the adrenal cortex, gonads and the brain. Aim. A clinical case is reported. Description of case. This article describes the case of a 64-year-old woman who had neurological symptoms for many years, gradually increasing without significant improvement after the treatment (periodic steroid therapy). Conclusion. Based on tests (including the determination of the ABCD1 gene and very long chain fatty acids - VLCFA), adrenoleukodystrophy was suspected.
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The potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine

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Natalia Leksa N., Anna Pękala A., Piotr Pardak P., Rafał Dziedzic R., Dorota Bartusik-Aebisher D., Rafał Filip R., Sabina Galiniak S., David Aeisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 1
20-23
EN
Introduction. Quantitative and accurate monitoring of tumor makes hyperpolarized carbon (13C) Magnetic Resonance Imaging and Spectroscopy (MRI/S) a powerful tool for in vivo metabolic and structural study. Moreover, the studies of the properties and functions in tumor tissue of the compounds of carbon (C) that are organic, are fundamental to tumor biochemistry. Aim. To review 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine Material and methods. An analysis of literature regarding 13C MR spectroscopy of polarized alanine. Results. Current evidence suggests that the determination of absolute configurations of amino acids play significant role in physiological mechanisms during tumor growth and treatment. Conclusions. Nearly 50% nuclear polarization for 13C can be achieved in various organic molecules when Dynamic Nuclear Polarization DNP is performed in a strong magnetic field and at cryogenic temperatures.
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Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development

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Anna Sęk-Mastej A., Sabina Galiniak S., Izabela Krawczyk-Marć I., Krzysztof Balawender K., Artur Szymczak A., Maciej Kaniewski M., Natalia Leksa N., Marek Biesiadecki M., Stanisław Orkisz S.
European Journal of Clinical and Experimental Medicine
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2018
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issue 2
85-91
EN
Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.
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