Search results

1

Plant medicinal products and drug interactions

100%

Łukasz Ożóg Ł., David Aebisher D., Zuzanna Bober Z., Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

|

2018

|

issue 1

37-40

EN

Introduction. Some herbal medicinal products may be beneficial in certain respects but many can be dangerous for patients taking doctor-prescribed medications. Plant medicinal products are often taken with conventional drugs by patients. Interactions are possible between herbal medicinal products and conventional medications that can lead to toxicity due to increaseddrug plasma levels or drug treatment failure. Aim. The aim of the study was to review the study of plant medicinal products and drug interactions. Materials and method. Analysis of literature.

2

The usefulness of relaxation time using MRI measurements

88%

Zuzanna Bober Z., David Aebisher D., Adrian Truszkiewicz A., Łukasz Ożóg Ł., Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

|

2018

|

issue 3

224-227

EN

Introduction. Magnetic Resonance Imaging methods are now frequently used for the analysis of the diseased tissue. These methods are based on the fact that the spin-lattice, T1 , and the spin-spin, T2 , relaxation times are different in diseased tissue as compared to that of normal tissue. Aim. Here we present measurements of spin-lattice relaxation time T1 on a Magnetic Resonance Imaging scaner with field strength 1.5 Tesla. Material and methods. Measurements of T1 relaxation time and analysis of literature. Results. We provide procedure for measurements of T1 relaxation time with field strength 1.5 Tesla and present a discussion of current applications.

3

Plants – a source of therapeutic material?

88%

Zuzanna Bober Z., Agnieszka Stępień A., David Aebisher D., Łukasz Ożóg Ł., Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

|

2018

|

issue 1

34-36

EN

Introduction. The use of plants with therapeutic or medicinal properties is as ancient as human civilization and for many years prior to the 20th century, plants and animal products were the main source of therapeutic medicinal drugs. Aim. The discovery of new plant-derived drugs continues to be an active field of research in medical science today. The aim of this article is to describe several main classes of natural products currently under investigation. Material and methods. Analysis of literature.

4

The potential of phythotherapy in otorhinolaryngology

88%

Wojciech Domka W., David Aebisher D., Zuzanna Bober Z., Łukasz Ożóg Ł., Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

|

2018

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issue 4

359–365

EN

Introduction. The objective of this paper is to review the evidence of the use of herbs in phytotherapy. Aim. To discuss plant properties and applications in otorhinolaryngology. Materials and methods. We analysed literature and collected information of phythotherapy in otorhinolaryngology. Results. The databases were searched using various keywords such as phytotherapy, otorhinolaryngology, and herbs such as: echinacea, eucalyptus, garlic, ginkgo, ginseng, kava, pelargonium sidoides, rosemary, spirulina, St John’s wort, and thyme. Conclusions. Due to the beneficial impact of meicinal plants in medicine there is a growing interest in analytical identification and quantification for clinical medicine and forensic toxicology.

5

Fundamentals of the use of Berberis as a medicinal plant

88%

Zuzanna Bober Z., Agnieszka Stępień A., David Aebisher D., Łukasz Ożóg Ł., Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

|

2018

|

issue 1

41-46

EN

Introduction. The daily use of medicinal plants has increased in recent years. The study of drugs of natural origin as an academic discipline and its applications in healthcare has changed remarkably but still focus on the quality of products and the development of new medicines. Aim. This study covers all fundamental aspects of pharmacognosy as well as topics relating to the therapeutic use of plant drugs known as phythotherapy. The purpose of the study was to review the literature about the use of Berberis. Materials and method. We reviewed the literature regarding the use of Berberis published between 1933 and 2018. We found more than 500 articles studying the properties of Berberis for digestive disorders, antibacterial, antidiabetic, hypotensive effects, anti-inflammatory effects, cholesterol regulation, cardiovascular disease, hyperlipidemia, cerebral ischemia trauma, mental disease, Alzheimer disease and osteoporosis. Our review includes recent studies regarding chemical composition and medicinal outcomes of Berberis

6

Medicinal benefits from the use of Black pepper, Curcuma and Ginger

88%

Zuzanna Bober Z., Agnieszka Stępień A., David Aebisher D., Łukasz Ożog Ł., Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

|

2018

|

issue 2

133-145

EN

Introduction. Black pepper, Curcuma and Ginger are three of the most popular and most frequently used spices. Due to their beneficial medical and pharmacological properties, they are increasingly appreciated phytotheraputic plants. Most of their actions are attributed to their biochemical compositions. Aim. Our intention is to equip the reader with the information and knowledge necessary to understand the role of natural products in the drug discovery process and to enable the assessment of potential benefits and harms of plant-based medicines when advising patients who wish to use them. Material and methods. Analysis of literature. Results. In this paper, we reviewed the use of Black pepper, Curcuma and Ginger documented in the treatment of colds and flu,

7

Radio Frequency MRI coils

88%

Adrian Truszkiewicz A., David Aebisher D., Zuzanna Bober Z., Łukasz Ożóg Ł., Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

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2020

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issue 1

24-27

EN

Introduction. Magnetic Resonance Imaging (MRI) coils technology is a powerful improvement for clinical diagnostics. This includes opportunities for mathematical and physical research into coil design. Aim. Here we present the method applied to MRI coil array designs. Material and methods. Analysis of literature and self-research. Results. The coils that emit the radiofrequency pulses are designed similarly. As much as possible, they deliver the same strength of radiofrequency to all voxels within their imaging volume. Surface coils on the other hand are usually not embedded in cylindrical surfaces relatively close to the surface of the body. Conclusion. The presented here results relates to the art of magnetic resonance imaging (MRI) and RF coils design. It finds particular application of RF coils in conjunction with bore type MRI scanners.

8

19F MRI As a tool for imaging drug delivery to tissue and individual cells

76%

Zuzanna Bober Z., David Aebisher D., Łukasz Ożóg Ł., Jacek Tabarkiewicz J., Piotr Tutka P., Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

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2017

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issue 2

99-109

EN

Over the past few decades, magnetic resonance imaging (MRI) has proven to be extremely successful in medical applications. More recently, the biomedical applications of MRI have been gaining more use in the field of clinical pharmacy. In 1977, perfluorocarbon compounds (PFC), which form emulsions that can carry drugs, were analyzed by 19F MRI and emulsified PFC compounds have been investigated as potential blood substitutes since the early 1960s and now a wide variety of PFC compounds are currently available as 19F MRI biomarkers. Molecules with 19F substituents are particularly attractive for use in drug tracking by 19F MRI due to 100% 19F abundance, high 19F MRI sensitivity (0.83 relative to 1H MRI) and an impressively large chemical shift range (400 ppm). Another benefit in the use of 19F MRI is a zero background signal in biological samples due to lack of endogenous fluorine. Therefore, drugs containing fluorine atom have potential for 19F MRI imaging drug delivery to tissue. This article will review recent developments in the use of 19F MRI in imaging drug delivery to tissue and individual cells.

9

Infliximab MRI relaxation time in solution

76%

Zuzanna Bober Z., Piotr Bar P., Grzegorz Pasternak G., Sabina Galiniak S., Dorota Bartusik-Aebisher D., Rafał Filip R., David Aebisher D.

European Journal of Clinical and Experimental Medicine

|

2019

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issue 1

22-25

EN

Introduction. The use of Quantitative Magnetic Resonance Imaging to drug monitoring in vitro or in vivo can provides a powerful means to map the effects of drugs on tissue activity. Aim. The purpose of this study was to measure relaxation time of antibody phantom. For this purpose, infliximab sample was used. Material and methods. The selected methods to detect relaxation time of antibody was Magnetic Resonance Imaging technique. We detected spin-lattice (T1 ) relaxation time and discuss differences where compare to water. Results. The measurements ofspin-lattice (T1 ) relaxation time showed significant differences. The results obtained in phantom indicate that we can use this result for measurements of relaxation time in vitro. Conclusion. Infliximab is approved for severe cases of rheumatoid arthritis, together with methotrexate, for pronounced psoriasis and psoriasis-arthritis, ankylosing spondylitis as well as for chronic inflammatory bowel disease. We conclude, that Quantitative Magnetic Resonance Imaging can be used to monitor drug effects

10

Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy

76%

Zuzanna Bober Z., David Aebisher D., Jacek Tabarkiewicz J., Wiesław Guz W., Piotr Tutka P., Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

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2017

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issue 2

110-119

EN

Currently, new and easier ways of analyzing pharmaceutical drug forms and drug delivery mechanisms are being sought. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that images drug forms such as tablets, liquids and topicals and drug form behavior in living organisms on both the tissue and cellular scale. The advantages of MRI include noninvasiveness, variable sample capacity and ease of transfer of phantom results to in vitro and in vivo studies. This review concerns the usefulness of clinical MRI that cannot be understated as this technique provides non-invasive and non-destructive insight into the properties of drug delivery systems. The research discussed here concerns the use of magnetic resonance, spectroscopy and chromatography to investigate selected pharmaceuticals and covers work of selecting drugs and antibodies for modification by synthesis for evaluation by MRI. Modifications have been aimed at improving therapeutic efficacy, delivery, and MRI. Modification conditions such as (pH, concentration, temperature, and the influence of other components present in the solutions) will be discussed to understand drug delivery system improvements and the reliability and repeatability of the results obtained. We hope to explore and expand the scope of pharmaceutical imaging with MRI for application in clinical medicine.

11

Magnetic Resonance Elastography – noninvasive method to assess liver disease

76%

Łukasz Ożóg Ł., David Aebisher D., Zuzanna Bober Z., Dorota Bartusik-Aebisher D., Wiesław Guz W., Marian Cholewa M.

European Journal of Clinical and Experimental Medicine

|

2017

|

issue 2

127-132

EN

Currently, liver disease is widespread and the awareness of these diseases is low. Early symptoms of liver disease do not necessarily indicate problems with this organ and patients are usually informed of their problems when the stage of the disease is already advanced. Invasive biopsies are the clinical diagnostic method most commonly used in the evaluation of liver disease. A biopsy is associated with a high risk of false results and additional complications. Finding new non-invasive imaging methods has led to the discovery of a new method called Magnetic Resonance Elastography (MRE). This technique allows one to evaluate the mechanical properties of tissues and to distinguish between pathological states. Testing using this technique can be performed on a conventional magnetic resonance system by using few additional components and properly prepared software. Studies have shown that there is a strong correlation between MRE-measured liver stiffness and the degree of fibrosis. MRE is also useful in characterizing liver tumors. Studies show that this technique is highly credible in both health volunteers and patients with liver fibrosis. MRE has tremendous diagnostic potential. The described technique is not currently widely used and has the 127-132potential to serve as a safe and accurate alternative in clinical diagnostics in the future.

12

Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1 H Magnetic Resonance Imaging in vitro

76%

Katarzyna Pogoda K., Maria Pucka M., Jacek Tabarkiewicz J., Zuzanna Bober Z., David Aebisher D., Sabina Galiniak S., Dorota Bartusik-Aebisher D.

European Journal of Clinical and Experimental Medicine

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2020

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issue 1

5-9

EN

Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.

13

ASL (Arterial Spin Labeling) – historical and current perfusion MR methods

64%

Wiesław Guz W., Zuzanna Bober Z., Łukasz Ożóg Ł., Adrian Truszkiewicz A., Aneta Przypek A., David Aebisher D., Dorota Bartusik-Aebisher D., Andrzej Urbanik A.

European Journal of Clinical and Experimental Medicine

|

2017

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issue 2

145-150

EN

Despite continuous scientific and technological advances in MR imaging, MR perfusion methods have not yet been widely deployed for routine clinical diagnostics. This is especially true for ASL (arterial spin labelling) methods used to evaluate cerebral perfusion. This method does not require a contrast agent, as new discoveries about gadolinium accumulation in the cerebellum and brain nucleus appear to be a valuable asset and provide the opportunity to be more widely deployed in clinical practice. The aim of this paper is to present the historical determinants of the development of MR perfusion techniques, the disadvantages and advantages and possible clinical applications and prospects of ASL development. Both historical articles published on MR in the 1990s and current research between 2006-2016 have been reviewed. The authors present in the work the MR perfusion method focusing on issues related to arterial spin labeling (ASL). Historically CASL (continuous ASL) and PCSL (pulsed ASL) techniques have been described and the pseudocontinuous ASL (pseudocontinuous ASL) 3D technique presents its technical and methodological considerations, advantages and disadvantages over previous methods. The methods of test protocol optimization and accompanying artifacts, as well as possible clinical applications and development perspectives, have been described.

14

Cytisine parameters measured in the 1.5 Tesla magnetic field

64%

Zuzanna Bober Z., Sabina Galiniak S., Dawid Leksa D., Klaudia Dynarowicz K., David Aebisher D., Elżbieta Ostańska E., Anna Czmil A., Piotr Bar P., Dorota Bartusik-Aebisher D., Piotr Tutka P.

European Journal of Clinical and Experimental Medicine

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2020

|

issue 1

16-19

EN

Introduction. Cytisine, Cytisinum (C11H14N2 O), is an organic chemical compound. Cytisine is heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. Aim. The aim of the study is to measure the influence of water on the form of drug in the magnetic field 1.5 Tesla. Material and methods. For this purpose, magnetic resonance imaging tests were performed to check the solubility of pure cytisine, Desmoxan tablets and Tabex capsules. Results. From a pharmacological point of view, both Desmoxan tablets and Tabex capsules should exert the same effect on the human body, this is due to the identical content of the active substance, in this case cytisine (1.5 mg). Conclusion. The differences in the results obtained may be related to additional excipients that contain medications, but it is believed that they should not have a negative impact on the action of the active substances.

15

Clinical application of advanced neuroimaging techniques – Magnetic Resonance Spectroscopy

64%

Wiesław Guz W., Zuzanna Bober Z., Łukasz Ożóg Ł., Adrian Truszkiewicz A., Aneta Przypek A., David Aebisher D., Dorota Bartusik-Aebisher D., Andrzej Urbanik A.

European Journal of Clinical and Experimental Medicine

|

2017

|

issue 2

133-140

EN

Continuous scientific research and the increasing saturation of the medical market in Poland implements the possibilities of using advanced MR techniques including MRS in everyday practice. This method, which has so far been used primarily for research purposes, can bring measurable benefits to patients not only in terms of clarifying diagnosis and narrowing differential diagnosis, but also monitoring the course of various diseases and their treatment. Here we present the basic principles of performing and interpreting spectroscopic spectra and possible clinical applications and development prospects of MRS. The literature reviewed both Polish and foreign articles both historically and in the past 10 years. The paper presents methodological issues related to the proper performance of magnetic resonance spectroscopy (MRS) and spectral composition and the role of major metabolites, as well as current clinical applications and directions of MRS development.

Refine search results

Plant medicinal products and drug interactions

The usefulness of relaxation time using MRI measurements

Plants – a source of therapeutic material?

The potential of phythotherapy in otorhinolaryngology

Fundamentals of the use of Berberis as a medicinal plant

Medicinal benefits from the use of Black pepper, Curcuma and Ginger

Radio Frequency MRI coils

19F MRI As a tool for imaging drug delivery to tissue and individual cells

Infliximab MRI relaxation time in solution

Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy

Magnetic Resonance Elastography – noninvasive method to assess liver disease

Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1 H Magnetic Resonance Imaging in vitro

ASL (Arterial Spin Labeling) – historical and current perfusion MR methods

Cytisine parameters measured in the 1.5 Tesla magnetic field

Clinical application of advanced neuroimaging techniques – Magnetic Resonance Spectroscopy