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Molecular profile of sensitization in subjects with short occupational exposure to latex

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Lamberti M., Buonanno R., Ritonnaro C., Giovane G., Crispino V., Feola A., Medici N., Sannolo N., Di Carlo A., Di Domenico M.

International Journal of Occupational Medicine and Environmental Health

2015

vol. 28

issue 5

841-848

Objectives We examined the prevalence of latex allergy in subjects with occupational exposure to latex allergens for less than 5 years, determining the disease spectrum in symptomatic workers. We identified the most frequent molecular allergens by Immuno- CAP (ICAP), correlating the findings with skin prick test (SPT) results. Material and Methods Seven hundred twenty-three healthcare students using latex gloves on a regular basis were invited to participate in a baseline questionnaire screening. An ICAP serum test was performed only when a possible latex allergy was indicated by the questionnaire. Results The total number of participants responding to the baseline survey was 619. Glove-related symptoms were indicated by 4% (N = 25) of the students. The most common symptom was contact dermatitis (N = 18, 72%). In 12 subjects, ICAP revealed a real sensitization to latex, with a recombinant latex allergen profile showing a high frequency for rHev b 6.01 specific immunoglobulin E (sIgE) (N = 9, 67%). In these individuals, skin symptoms were more prevalent than other types (88%). Conclusions The combined positivity for rHev b 6.01, rHev 8 and rHev b 5 determined by ICAP identified 92% of latex-allergic subjects with short-term exposure to latex.

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1 International Journal of Occupational Medicine and Environmental Health

1 Buonanno R.

1 Crispino V.

1 Di Carlo A.

1 Di Domenico M.

1 Feola A.

1 Giovane G.

1 Lamberti M.

1 Medici N.

1 Ritonnaro C.

1 Sannolo N.

1 2015

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Molecular profile of sensitization in subjects with short occupational exposure to latex