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Urolithiasis due to renal dystopia and vascular anomalies

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Anna Pliszka A., Michał Kłos M., Klaudia Możdżeń K., Krzysztof Balawender K.
European Journal of Clinical and Experimental Medicine
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2021
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issue 1
89-92
EN
Introduction. Variations in the urogenital vascular anomalies in the abdomen are common. However, they warrant attention due to their importance in operative, diagnostic, and endovascular procedures. Aim. The aim of this article is to show an example of a patient with rare kidney and vessels anomalies. We want to prove that those anomalies contributed to development of urolithiasis in this case. Description of the case. During dissection of abdomen in a female cadaver, unique vascular anomalies and a position disorder of both kidneys were observed. Conclusion. Vessel abnormalities were congenital and appeared simultaneously with renal dystopia. Both anomalies could contribute to stone formation and nephritis. Understanding of the urogenital anatomical variations and their relations to adjacent structures is significant during surgical and radiological procedures.
2
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A renal abscess in the isthmus of horseshoe kidney

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Krzysztof Balawender K., Stanisław Orkisz S., Przemysław Biela P., Anna Sęk-Mastej A.
European Journal of Clinical and Experimental Medicine
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2017
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issue 3
279-281
EN
Horseshoe kidney (HSK) is the renal fusion anomaly caused by disturbances in embryonic development when the kidneys are fused together in the lower or upper pole forming an isthmus. The most common disorders in urinary tract related to horseshoe kidney are ureteral pelvic junction obstruction, urinary tract infection and urolithiasis. In our study, we present a rare case of an abscess in the isthmus of horseshoe kidney after extracorporeal shockwave lithotripsy on the right kidney was performed. The patient has had recurrent urolithiasis and underwent 4 treatments on the left kidney in the past without complications.
3
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Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development

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Anna Sęk-Mastej A., Sabina Galiniak S., Izabela Krawczyk-Marć I., Krzysztof Balawender K., Artur Szymczak A., Maciej Kaniewski M., Natalia Leksa N., Marek Biesiadecki M., Stanisław Orkisz S.
European Journal of Clinical and Experimental Medicine
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2018
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issue 2
85-91
EN
Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.
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