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1
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Singlet oxygen lifetime and diffusion measurements

100%
Łukasz Ożog Ł., David Aebisher D.
European Journal of Clinical and Experimental Medicine
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2018
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issue 2
123-126
EN
Introduction. Photodynamic therapy (PDT) is considered to be a promising antitumor methodology due the cytotoxicity of singlet oxygen (1 O2 ). Aim. To present singlet oxygen which is highly reactive and decomposes to the ground state rapidly. Material and methods. Analysis of literature. Results. This review presents techniques to measure lifetime and diffusion of 1 O2.
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Methods of singlet oxygen generation and detection for understanding photodynamic processes

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Łukasz Ożog Ł., David Aebisher D.
European Journal of Clinical and Experimental Medicine
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2018
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issue 3
228-232
EN
Introduction. Photodynamic therapy (PDT) is a clinically approved therapeutic procedure that exerts selective cytotoxic activity toward malignant cells. Aim. Our goal is to present the PDT procedure which involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to the absorbance band of the photosensitizer and energy transfer to ground state oxygen to generate cytotoxic singlet oxygen Material and methods. Analysis of literature. Results. In this paper we described the basics of PDT and lifetime of singlet oxygen in different media.
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Fibromatosis-like spindle-cell metaplastic carcinoma of the breast – a case report

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Michał Osuchowski M., Dorota Bartusik-Aebisher D., Ewa Kaznowska E., David Aebisher D.
European Journal of Clinical and Experimental Medicine
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2021
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issue 1
98-101
EN
Introduction. Metaplastic breast carcinoma is expressing epithelial and/or mesenchymal tissue within the same tumor. Aim. The aim of this study is to evaluate metaplastic breast carcinoma in a case report and literature review. Description of the case. The presented case desribes metaplastic carcinoma of the breast in 65 years old female patient. Conclusion. Fibromatosis-cell metaplastic carcinoma of the breast presents a particularly large diagnostic challenge. Malignant variants of this disease have been described in the literature.
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Chemiluminescence-driven Dye Excitation for Dark Photodynamic Therapy

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Łukasz Ożóg Ł., Jacek Tabarkiewicz J., David Aebisher D.
European Journal of Clinical and Experimental Medicine
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2017
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issue 2
95-98
EN
Photodynamic therapy is a treatment that uses a combination of light-absorbing photosensitizers and dissolved oxygen to kill cancer. One specific limitation of photodynamic therapy is that the visible light used for photosensitizer excitation has a short tissue penetration depth of several millimeters. This limits the application of photodynamic therapy to surface cancers in the absence of a technique to illuminate deeper tissue. Efforts to extend tissue depth to which photodynamic therapy can be applied have been attempted with use of up-conversion and persistent-luminescent nanoparticles that absorb near infrared light and emit visible light for photosensitizer excitation, yet an initial excitation with an external light source is still required. More recently, systems employing chemiluminescence as an excitation energy source designed to bypass the use of external light have been developed and investigated as potential agents that could overcome the problem of achieving photodynamic therapy in deep tissue. We wish to provide an overview of several systems that have been recently reported that employ both radiative and non-radiative chemiluminescent energy transfer for photosensitizer excitation that have been developed in the hope of achieving “dark” photodynamic therapy. This article reviews several of these important new developments in the design of photodynamic therapeutic systems that utilize chemiluminescence.
5
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The significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice

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Tomasz Kubrak T., Rafał Podgórski R., David Aebisher D., Agnieszka Gala-Błądzińska A.
European Journal of Clinical and Experimental Medicine
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2018
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issue 1
28-33
EN
Introduction. Despite advances in medical care AKI (acute kidney injury) is associated with high morbidity and mortality. The lack of adequate early renal injury biomarkers is often a problem for an early AKI diagnosis. In recent years, numerous scientific studies have been carried out which reveal new urine and serum markers to assess the period of the kidney injury before revealing its late clinical effects. In most clinical settings, AKI is due to acute renal tubular necrosis which results in protein accumulation in urine. Determination of the concentrations of proteins such as NGAL (neutrophil gelatinase-associated lipocalin) and KIM-1 (kidney injury molecule-1) are of great significance in the diagnosis of AKI. Aim. The purpose of the study was to review the literature about significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice. Materials and method. Analysis of Polish and foreign literature.
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Anticancer properties of Viburnum

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Agnieszka Stępień A., David Aebisher D., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2018
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issue 1
47-52
EN
Aim. The aim of this paper is to provide an overview of the anticancer properties of different species of Viburnum. Materials and methods. Forty nine papers that discuss the medicinal history and current research of Viburnum species as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research conducted in vitro indicate that the compounds present in the extracts of Viburnum significantly affect the development of cancer cells such as leukemia, cervical cancer, breast, colon, lung, skin and stomach. This indicates that they may be used as a therapeutic agent to support oncological therapies.
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Treating kidney cancer – a review

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Piotr Przyczyna P., David Aebisher D., Dorota Bartusik-Aebisher D., Ewa Kaznowska E.
European Journal of Clinical and Experimental Medicine
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2020
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issue 1
38-41
EN
Introduction. Kidney cancer in the structure of registered cases was in 6th place in men and 8th in women. Aim. Understanding the molecular biology of renal cell carcinoma has made it possible to produce new diagnostic methods. Material and methods. This review was performed according to a systematic literature search. Results. Minimally invasive techniques seem to have a bright future in kidney cancer. However, they still require many clinical trials before they enter the general clinical use. Conclusion. Photodynamic therapy, thanks to research conducted in kidney cancer, will find application in cancer of other organs.
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The larynx cancer in vitro study by MRI relaxtion time of water

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Wojciech Domka W., Łukasz Ożóg Ł., Dorota Bartusik-Aebisher D., David Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 3
185-187
EN
Introduction. Squamous cell carcinoma (SCC) of the larynx accounts for a significant percentage of all head and neck cancers. Aim. In this paper we determine the differences in magnetic resonance relaxation time (MRI) of water in cancerous and healthy larynx tissues. Material and methods. This study is aimed on T2 MRI modalities for monitoring morphology of larynx tissue. Results. Our results showed that T2 MRI relaxation time measured in larynx tissue can be used to assess early cancer condition of larynx tissues. The changes of T2 MRI correspond to tumor growth within normal tissue. Conclusion. The study showed potential of MRI for the non-invasive monitoring of larynx condition.
9
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Crohn’s disease complicated with a bladder-fistula – a case report

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Grzegorz Pasternak G., Dorota Bartusik-Aebisher D., David Aebisher D., Rafał Filip R.
European Journal of Clinical and Experimental Medicine
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2021
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issue 1
76-80
EN
Introduction. Entero-bladder fistula (fistula entero-vesicalis) is a pathological connection between the lumen of the gastrointestinal tract and the bladder. Entero-bladder fistulas are not a common condition. The main reason for the formation of entero-bladder fistulas are intestinal diseases occurring within the intestinal loop adjacent to the bladder resulting in the formation of an abnormal channel, the connection between the above structures Aim. The aim is to present the causes of the fistulas can be divided into congenital and acquired (intestinal infection, cancer, Crohn’s disease, resulting from trauma and iatrogenic). Clinical manifestations of the biliary-bullous fistulae may be from the digestive or urinary tract. The most characteristic ailments are pneumaturia, fecuria, urge to urinate, frequent urination, lower abdominal pain, hematuria, urinary tract infection. Description of the case. The article discusses the case of a patient with Leśniowski-Crohn disease complicated with a bladder-fistula. The treatment of entero-bladder fistulas is primarily surgical, it consists in resection of the fistula together with resection of the affected intestine and bladder wall fragment. Conclusion. The test confirming the presence of an entero-bladder fistula is a test with oral administration of poppies, although it happens that the test result may be negative, especially in the case of a bladder-follicular fistula. Among the tests useful in the diagnosis of entero-bladder fistula include abdominal ultrasound, computed tomography, magnetic resonance imaging, endoscopic tests (colonoscopy or cystoscopy).
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Inflammatory bowel disease: the function of metalloproteinases

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Grzegorz Pasternak G., David Aebisher D., Rafał Filip R., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2018
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issue 4
346-349
EN
Introduction. Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Aim. The aim of this work was to review the current literature regarding matrix metalloproteinases. The databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles. Materials and methods. An analysis of literature. We collected information, data, and examples of the function of metalloproteinases. Results. Herein we show that metalloproteinases play a role in such processes as the immune response, angiogenesis, the epithelial barrier function, fibrosis induced by the inflammatory process, and in the process of carcinogenesis. Conclusions. Further studies on the role of metalloproteinases in the process of carcinogenesis associated with inflammatory bowel diseases are required.
11
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Receiver operating characteristic analysis of the FeNO biomarker in the diagnosis of asthma

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Marek Biesiadecki M., Sabina Galiniak S., Dorota Bartusik-Aebisher D., David Aebisher D.
European Journal of Clinical and Experimental Medicine
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2018
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issue 4
253-258
EN
Introduction. The fraction of exhaled nitric oxide (FeNO) is used as a non-invasive biomarker that reflects inflammation in the airways. It is so versatile that it used to control asthma severity as well as to monitor response to treatment. However, the exact cut-off point of the nitric oxide level which allows one to make a precise diagnosis of asthma is unclear. Aim. To examine the possibility of using advanced statistical methods such as receiver operating characteristic for the analysis of FeNO concentrations for improving the diagnosis of asthma. Materials and methods. Receiver operating characteristic (ROC) was used for analyzing results to determine levels of nitric oxide which may be a prognostic indicator of asthma. The studied group consisted of 111 children including 69 asthmatic patients, and 42 age- and sex-matched healthy subjects. Measurement of exhaled nitric oxide was conducted in all subjects included in this study. Results. FeNO level was higher in asthmatic patients. The analysis of results showed that the cut-off point for the FeNO concentration is 11.5 ppb. Sensitivity and specificity with the FeNO level allowed us to determine a value of the diagnostic variable of FeNO concentration of 14.0 ppb. A comparison of FeNO level and sex of the subjects showed there is no correlation between these parameters of patients. Conclusions. Currently, the FeNO measurement provides complementary d
12
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Neoadjuvant therapy in breast cancer – objectives and tasks

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Elżbieta Ostańska E., Dorota Bartusik-Aebisher D., David Aebisher D., Ewa Kaznowska E.
European Journal of Clinical and Experimental Medicine
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2019
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issue 2
153–156
EN
Introduction. Neoadiuvant therapy (NCT) in the treatment of breast cancer is employed for patients with early stage disease or with inoperable disease. NCT can decrease the tumor volume. It can facilitate breast conservation therapy. Response to NCT is a strong predictor of outcome breast cancer (BC). Direct target therapies has markedly improved the result of treatment BC. Aim. Therapy for breast cancer continues to improve. The importance of tumor burden on local control rates will be in the future. Material and methods. This analysis was performed using a systematic literature search. Results. The latest scientific reports give hope for greater safety and a better life for patients based on optimized and effective therapy. Conclusion. Currently, improving the effectiveness of breast cancer treatment is mainly related to the optimal use of classic therapeutic strategies. New classes of substances have been approved for treatment or are in advanced stages of clinical development.
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Bladder Mullerianosis – a case report

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Elżbieta Ostańska E., David Aebisher D., Ewa Kaznowska E., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2019
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issue 3
277-280
EN
Introduction. Bladder mullerianosis is a rare and proliferative lesion that contains at least two types of ectopic Mullerian tissue in its wall. Aim. To present case of bladder mullerianosis. Description of case. The text contains a description of a clinical case of a 50-year-old woman admitted to a gynecological ward due to diarrheal symptoms and abdominal pain. In a CT examination of the abdominal cavity with contrast, within the posterior left-sided wall of the bladder a 43x25mm proliferative lesion suggestive of neoplastic character was revealed. Transurethral resection of the lesion (TURB) was performed. Histopathology revealed endosalpingiosis with small endocervical foci. The picture of hyperplasia met the criterion of mullerianosis. Conclusion. Bladder Mullerianosis is a very rare disease that occurs mainly in women of reproductive age. It has very good prognosis. It is important to differentiate the lesion with malignant tumor. The basis for the diagnosis is the histopathological examination of the lesion tissues taken during the surgery.
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Efficacy and safety of biosimilar IFX (CT-P13) and adalimumab in patients with active fistulizing perianal Crohn’s disease naïve to anti-TNF therapy: preliminary results from the POLIBD study

81%
Anna Pękala A., David Aebisher D., Piotr Pardak P., Rafał Filip R.
European Journal of Clinical and Experimental Medicine
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2019
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issue 1
12-15
EN
Introduction. The development of perianal fistulas are a risk factor in colonic and rectal disease. Perianal CD treatment requires a combination of surgical and therapeutic treatments aimed to prevent septic complications, reduce fistula discharge and ultimately heal fistulas. Aim. The purpose of the study was to evaluate the efficacy and safety of biosimilar IFX (CT-P13) and adalimumab in active fistulizing perianal Crohn’s disease (CD) in patients from the Subcarpathian Region (South-Eastern Poland). Material and methods. Thirty patients with CD with perianal fistulas naïve to anti-TNF therapy were enrolled (13 females/ 17males) ranging from 18 to 64 years of age. Twenty-one were treated with biosimilar infliximab (CT-P13), nine were treated with adalimumab (ADA). The treated patients had ileal CD (4), ileo-colonic CD (13) or colonic CD (13). All of them received standard immunosuppression with no additional steroid therapy. Response was evaluated at week 16 and 40 after the first CT-P13 dose, and 16 and 40 weeks after the first ADA dose. Remission was defined as the complete closure of all fistulas and partial response as a reduction (≥50%) in the number of draining fistulas. Results. Treatment outcomes with CT-P13 and ADA were both effective and similar in the percentage of patients with perianal fistula improvement, perianal fistula remission, no effect or observed adverse events. Conclusion. In patients with active fistulizing CD, both CT-P13 and ADA were effective and safe, however a slight superiority of CT-P13 was visible
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Brachial artery injury

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Krzysztof Milik K., Grzegorz Pasternak G., David Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 2
141-145
EN
Introduction. Arterial damage associated with musculoskeletal injuries at room conditions is very common. Aim. It is worth remembering that examining a patient who has suffered an accident with a broken bone or traumatic joint dislocation may be accompanied by vascular damage. A dislocation or fracture often masks damage to the artery. Description of the case. In this paper, a 20-year-old patient being a passenger suffered upper right limb trauma in a car accident. Conclusion. The effects of vascular injuries appear only after a few hours after setting the fracture. It is not known then whether the artery was damaged at the same time with the fracture, whether the injury occurred during the adjustment, or whether the ischemia is finally the result of the pressure exerted by too tight plaster casts.
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Primary breast angiosarcoma – a case report

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Elżbieta Ostańska E., David Aebisher D., Ewa Kaznowska E., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 4
331-334
EN
Introduction. Angiosarcoma is a rare breast cancer that can be primary or secondary after surgery or after breast cancer radiotherapy. It is important that breast angiosarcoma belongs to tumors with a non-specific clinical and radiological picture. Aim. The study of the biopsies contained aggressive vasomotor hyperplasia. Description of the case. The presented case concerns the primary angiosarcoma of the right breast in a 56-year-old woman who had never had a surgical procedure before, nor radiotherapy in the area of the breast. Conclusion. Histopathological examination supported by immunohistochemistry is a reliable and indispensable diagnostic element in the diagnosis of vascular sarcoma.
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Biological properties of Cistus species

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Agnieszka Stępień A., David Aebisher D., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2018
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issue 2
27-132
EN
Aim. This paper presents a review of scientific studies analyzing the biological properties of different species of Cistus sp. Materials and methods. Forty papers that discuss the current research of Cistus sp. as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research indicate that extracts from various species of Cistus sp. exhibit antioxidant, antibacterial, antifungal, anti-inflammatory, antiviral, cytotoxic and anticancer properties. These properties give rise to the possibility of using Cistus sp. as a therapeutic agent supporting many therapies
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Hyalinising clear cell carcinoma of salivary gland: a case report

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Michał Osuchowski M., Dorota Bartusik-Aebisher D., Ewa Kaznowska E., David Aebisher D.
European Journal of Clinical and Experimental Medicine
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2020
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issue 2
127-130
EN
Introduction. Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland (HCCC) is a malignancy that arises in minor salivary glands. It rarely leads to distant metastases or cancer-related death but has the potential for recurrence and focal metastases. Aim. A case is reported. Description of the case. A 72 years old female patient has reported to the Clinic of Otolaryngology with a tongue lesion. The patient had no history of malignancy. The lymph node has been surgically removed for further examination. Cords and nests of clear cells and cells with eosinophilic cytoplasm in a hyalinized stroma were identified within the lymph node. After the diagnosis the patient has been transferred to another Oncology Hospital for further treatment. Conclusion. The diagnosis of clear cell carcinoma may be challenging because many of it‘s features frequently overlap with other salivary gland lesions.
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Crohn’s disease – a case study

81%
Grzegorz Pasternak G., Dorota Bartusik-Aebisher D., David Aebisher D., Rafał Filip R.
European Journal of Clinical and Experimental Medicine
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2021
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issue 1
93-97
EN
Introduction. Surgical treatment of patients with Crohn’s disease can be a big challenge, due to the high risk of complications that is associated with chronic inflammatory process, immunosuppressive, biological treatment, malnutrition, patient’s wasting or prone to recurrence of inflammatory changes. Aim. The aim of this work ist o present the case of patient underwent surgery, resection of the terminal ileum, right hemicolectomy and segmental jejunum resection. Description of the case. In this case patients with Crohn’s disease were accompanied by progressive nutritional deficiencies and cachexia. Conclusion. Crohn’s disease can lead to very severe abdominal and septic complications that require long-term treatment, repeated surgery, and open belly therapy with the use of vacuum therapy
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Imaging methods of early detection and screening for breast cancer. A review

81%
Joanna Gustalik J., Dorota Bartusik-Aebisher D., David Aebisher D., Ewa Kaznowska E.
European Journal of Clinical and Experimental Medicine
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2019
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issue 2
142-145
EN
Introduction. Breast cancer is the most frequent neoplasm among women. That is the reason why scientists all over the world are attempting to improve early detection methods of this particular malignancy. Aim. The most common and most widely used examination methods for screening for and detecting breast cancer is presented herein. Material and methods. This review was performed according to systematic literature search of three major bibliographic databases. Results. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. Conclusion. The role of a physician is to select the most suitable one for each patient in order to obtain the best result. No matter the method however, between 2005 and 2011, the 5-year relative survival was found to be 89%. This is thought to be due to both the increase in utilization of population-wide screening, as well as advances in treatment.
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