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RELATIONSHIP BETWEEN WORKING MEMORY AND EXECUTIVE FUNCTION AND POLYMORPHISM OF BDNF (BRAIN DERIVED NEUROTROPHIC FACTOR) GENE IN HEALTHY SUBJECTS

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Borkowska A., Wilkosc M., Tomaszewska M., Skibinska M., Dmitrzak-Weglarz M., Drozdz W., Hauser J.
Psychologia-Etologia-Genetyka
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2007
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vol. 16
33-47
EN
Current studies on cognitive processes focused also on specificity and neurobiology of working memory. Working memory is mostly connected with the activity of prefrontal cortex, and their disturbances are an important element in the etiopathogenesis of mental illnesses. Activity of different neurotransmitters and also neurotrophic systems, especially brain derived neurotrophic factors (BDNF) play an important role in memory processes. It is also important in brain developmental processes and the polymorphism of BDNF gene now is in the center of genetic-molecular studies on working memory processes. The aim of this study was to evaluate a relation between polymorphisms Val66Met and C-270T of BDNF gene and the efficiency of working memory measured by neuropsychological tools: Wisconsin Card Sorting Test (WCST), Stroop test and Trail Making Test A&B in healthy subjects. The study was performed on 90 healthy volunteers (33 women, 57 men) aged 18-58 years. The results obtained have demonstrated the relation between performance on some of neuropsychological tests and polymorphism C-270T of BDNF gene, and the relationship was different in male and female group. However no association between the performance of the neuropsychological tests and polymorphism of Val66Met of BDNF gene was found. The results indicate different influence of the BDNF gene polymorphisms in working memory processes.
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