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Obesity as illness of million people on all over the world is being investigated in many different clinical trials by many group of scientists. Attempt of revealing and understanding of every single factor which may influence on occurring obesity will take us many years. Obesity affects more and more adults and children each year. Most interesting trials of obesity are these which connect many disciplines. Psychological and neuropsychological data connected with biochemical, molecular and genetic results are important in completing etiopathology of obesity. Searching for endogenic substances influences on energetic balance leads to finding new rules for well known substances as cortisol or leptin. New interesting substances connected with nutrition are found also very often. For example, visfatin is compound which roles id pathogenesis of obesity is not well known. Observation of results recently published suggests that particularly interesting data are these where psychological and neuropsychological data are combination with genetic data. Genetic study among candidate genes as BDNF, DAT1, 5-HT2A indicates existence of specific polymorphism which predispose to higher BMI. Obesity is important and interesting for many medical and psychological scientists. Many aspects of obesity's problems are challenge for investigators. The results of clinical trials may give hope for obese patients for improving quality of life and better functioning in daily life.
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