Results found: 2

Search results

Search:
in the keywords: Glucagonoma

Sort By:

Limit search:

PRRT as an alternative method of treatment in patient with glucagonoma syndrome: A case report

100%

Popławska-Kita A., Szyszkowska A., Brelska P., Kowalczuk M., Szostek A., Popławski Ł., Siewko K., Szelachowska M., Kamiński G., Werel D., Górska M.

Progress in Health Sciences

2016

vol. 6(1)

209-214

Introduction: Glucagonoma is a rare pancreatic neuroendocrine tumor derived from alpha-cells of the islet of Langerhans. Due to oversecretion of glucagon it is associated with a characteristic paraneoplastic phenomenon, called glucagonoma syndrome, which consists of necrolytic migratory erythema (NME), weight loss, diabetes mellitus, diarrhea, normochromic normocytic anemia, deep vein thrombosis or pulmonary embolism and neuropsychiatric disturbances. Treatment modalities include surgical removal of tumor, somatostatin analogs and peptide receptor radionuclide therapy (PRRT). Case report: We present a case of 61-year-old woman diagnosed with glucagonoma in April 2012. Initially, body-caudal pancreatomy and resection of regional lymph nodes were performed. Five months after surgery, a PET-CT scan detected pathological mass with expression of somatostatin receptors in pancreatic body and metastases to regional lymph nodes. What is more, since April 2014 the patient had complained about persistent pruritus of the entire body. At present, due to the nonsurgical pancreatic mass and metastases she is treated with somatostatin analogs and PRRT. During this therapy the pruritus had decreased and currently there is no sign of cutaneous disease. Moreover, reduction of tumor size was obtained. Conclusions: PRRT may reduce tumor size and by reducing bothersome symptoms substantially improve the quality of life in patients with SSTR-positive tumors

Glucagonoma as a rare case of neuroendocrine tumor of the pancreas: a case report

100%

Zińczuk J., Lewoniewska S., Zaręba K., Pryczynicz A., Guzińska-Ustymowicz K.

Progress in Health Sciences

2019

vol. 1

169-173

Introduction: Glucagonoma is a rare neuroendocrine tumor with characteristic features such as the presence of the glucagon-producing tumor, diabetes, and necrolytic migratory erythema. Case presentation: the 60-year-old patient was admitted to hospital with periodic pain in the right and middle upper abdominal appearing after eating. Laboratory tests presented a high glucose level and anemia. Tumor of the body and tail of the pancreas passing the organ pouch has been found during the surgery. Diagnosis of glucagonoma was confirmed in histopathological examination in immunohistochemical stainings: a positive reaction was observed with chromogranin, synaptophysin and CEA. The proliferative activity of Ki-67 was less than 1%. Staining for glucagon also was positive so confirmed the presence of neuroendocrine tumor - glucagonoma. Conclusions: Glucagonoma sometimes may occur without characteristic features which may cause delayed diagnosis. Early diagnosis of glucagonoma is important because it increases the chances of successful recovery.

Refine search results

2 Progress in Health Sciences

1 Brelska P.

1 Guzińska-Ustymowicz K.

1 Górska M.

1 Kamiński G.

1 Kowalczuk M.

1 Lewoniewska S.

1 Popławska-Kita A.

1 Popławski Ł.

1 Pryczynicz A.

1 Siewko K.

1 Szelachowska M.

1 Szostek A.

1 Szyszkowska A.

1 Werel D.

1 Zaręba K.

1 Zińczuk J.

1 2019

1 2016

Search results

PRRT as an alternative method of treatment in patient with glucagonoma syndrome: A case report

Glucagonoma as a rare case of neuroendocrine tumor of the pancreas: a case report