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EN
Purpose: To evaluate the hypothesis that vitamin C improves the efficacy of Helicobacter pylori eradication in smokers when combined with pantoprazole, amoxicillin, and clarithromycin. Materials and methods: The study completed 90 subjects of 98 enrolled, 58 smokers 32 nonsmokers. Helicobacter pylori status was determined by two methods, CLO test, and histology. Vitamin C (500 mg) was administered three times daily. The patients were considered as cured of H. pylori if the CLO test result and histology were negative 4 weeks after completion of eradication therapy. Results: Smokers had lower effectiveness of eradication therapy than non-smokers and the administration of vitamin C had not affected the outcome of eradication therapy. Conclusions: Vitamin C (500 mg tid) does not improve the eradication therapy when pantoprazole, amoxicillin, and clarithromycin were used.
EN
Purpose: The aim of the study was to conduct a 15- year (1996-2011) observations on the frequency of Helicobacter pylori stomach infection in patients having performed gastroscopy in the Endoscopy Unit District Hospital of Białystok, Poland Materials and methods: Out of the 27421 patients who underwent a gastroscopy in 1996-1997, 2000- 2001, 2005-2006, and 2010-2011 years were selected 4216 subjects who had performed histological examination of gastric mucosal specimens for H. pylori infection. The mucosal specimens after placed in buffered formalin, were subjected to standard histological procedure, and stained with hematoxylineosin and Giemsa. Results: Stomach infection with H. pylori was 73.36% (1996-1997), 48.60% (2000-2001), 33.61% (2005-2006) and 32.30% (2010-2011); only between the last two 2-year intervals the difference was not significant. Conclusions: The results of current study indicate on steadily declining stomach infection with H. pylori. Keywords: Helicobacter pylori, histology, gastric mucosa
EN
Helicobacter pylori – Gram-negative rod, discovered more than 30 years ago, has a proven influence on inflammation of gastric and duodenal mucosa. The worldwide prevalence of H. pylori infection in the human population is estimated at 50% and is considered to be one of the most frequent bacterial infections in people. Many studies suggest that infection takes place in the early childhood within the family. The gastric mucosa is its natural habitat. In last time more and more findings about existence of this bacteria in another places of gastrointestinal tract and correlation with many diseases, especially an inflammation of oral cavity. The percentage of H. pylori detectability in the oral cavity ranges from 0 to 100%. Thus, more studies aimed at final determination of the bacterium reservoir in the oral cavity seem to be necessary.
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