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Objectives: The objective of this article is to establish a research protocol to determine if there is an association between the flu vaccine and Guillain-Barré Syndrome (GBS). Methods: A case-control study will be carried out to determine whether or not there is a relationship between the flu vaccine and the GBS. For each case of GBS a control of the same sex and of similar age will be selected, and it will be determined if they have been exposed to the flu vaccine, in order to determine whether this vaccine increases the risk of suffering from GBS. Findings: The flu vaccine is not expected to be associated with an increased risk of GBS. Such a result would be of great importance for the patients and for the healthcare system. It would contribute decisively to reassure the general population, especially the risk groups that can benefit from flu vaccine, being able to inform them of its safety. Conclusions: It is recommended to carry out this protocol in different health centers to obtain reliable conclusions about the possible association between flu vaccine and GBS.  
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