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Predictive value of blood urea nitrogen to serum albumin ratio in estimating in-hospital mortality in patients with upper gastrointestinal bleeding

100%
Kurt E., Eke Kurt S. Z.
European Journal of Clinical and Experimental Medicine
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2022
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issue 3
342-347
EN
Introduction and aim. The aim of this study was to examine the usability of blood urea nitrogen to serum albumin ratio (BAR) as a prognostic predictor of in-hospital mortality in patients with gastrointestinal (GI) bleeding. Material and methods. The electronic medical records of the patients who applied to the emergency department due to upper GI bleeding during the study period were reviewed. The receiver operating characteristic (ROC) curve and the area under the curve (AUC) were used to evaluate each discriminant cut-off value to estimate mortality. Results. The study included 225 patients. The median (IQR) age of the patients was 75.0 (68.0–84.0) and 94 (41.8%) were female. AUC was determined as 0.784±0.055 (95% CI, 0.677–0.892) for BAR (p<0.001) in terms of in-hospital mortality. The cut-off value of BAR for this outcome was calculated as 16.26. In this cut-off value, sensitivity was 71.43%, specificity 82.84%, positive predictive value (PPV) 30.00% and negative predictive value (NPV) 96.57%. Conclusion. BAR is a useful tool that can be used to predict the in-hospital mortality of patients with GI bleeding. Patients with GI bleeding with a BAR above 16.26 will require more aggressive and timely intervention.
2
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Badania technologiczne trzech nagrobnych stel egipskich na podłożu drewnianym z Muzeum Narodowego w Krakowie : część I

88%
Szyszko W.
Ochrona Zabytków
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1972
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issue 3
170-182
EN
The a u th o r of th e p re s e n t a rtic le dev o ted his co n sid e ra tio n s to th e se t of th r e e E g y p tian e p ita p h ia l ste la e on wood su p p o rts a t p re s e n t being a p ro p e rty of th e C z a rto ry sk i Collection, N a tio n a l Museum, C ra cow. The ab o v e -m en tio n ed objects, up to th e p re s e n t day n o t published, a re ap p ro x im a te ly d a tin g from th e second millen ium B.C. w ith an ex c ep tio n of th e stele XI-645 which, according to ev e ry p ro b ab ility , is one much la te r. The a rtic le is composed of two p a rts. W ith in th e firs t of th em th e re su lts of in v e stig a tio n s a re p re sen ted , however, exclu d in g th e pigm en ts th e an a ly sis of which fo rms th e second p a r t of th is p u b lic a tio n . P re s en tin g th e s ta te of in v e stig a tio n s of Eg y p tian polychromies th e a u th o r tu rn s to an a ly sis of th e se p a ra te la y e rs on th e basis of s tra ty g ra p h ic e x am in a tio n s of objects. The re c e n t e x am in a tio n s h ave shown th a t th e ste la e were p roduced w ith th e use of A fric an mah ogany wood (Sapeli) which th e k in d of wood had not up to now b e en men tio n ed in Egyptologic lite r a tu re . By th e use of m ic ro -c ry sta llo g rap h ic m e th o d it has been found th a t all th e ob je c ts u n d e r co n sid e ra tio n were p a in te d on gypsum p rim e r co n sid e rab ly co n tam in a ted w ith m e ta lic adm ix tu re s. While te s tin g th e samples of p rim e r th e following m ethods w e re used: sp e c tro p h o tom e try in in f r a - r e d light, emission sp e c tro g rap h y , m ic ro -c ry s ta llo g ra p h y and th e p a p e r ch rom a to g rap h y to fin d th e tr a c e s of p ro te in m a tte rs. Samples of b in d e r p re s e n t in th e p a in te d la y e r w e re in v e stig a ted w ith th e use of b oth p a p e r and th in - la y e r ch rom ato g rap h y . The re su lts of ana ly se s p o in t to th e use of gum b in der, p ro b ab ly tra g a c a n th gum. In add itio n , th e a u th o r has ex am in ed th e side cuts ta k en from th re e ob je c ts and basing on X -ra y d iag ram s he g a th e red some d a ta re la tin g to th e s tru c tu re of support. No less in te re stin g p ro v ed to be th e re su lts of mycological in v e stig a tio n s c a rried o u t on th e su rfa c e s of stelae. Among those p re s e n t in ste la e some species of fu n g i w e re id en tified belonging to A sp e rg illu s and Pén ic illium fam ilie s and, besides, th e Clo ck er sp. y easts whose p re sen c e may prove d an g e ro u s fo r th e se u n u su a lly v a lu ab le objects. Within th e p re s e n t p u b lic a tio n th e emp h a sis h a s been laid u p o n th e d a ta re fe rrin g to in d iv id u a l p ro b lem s and a t th e same tim e th e d a ta coming from lite r a tu r e h av e been con fro n ted w ith re su lts of th e a u th o r ’s own investigations.
3
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Post-exercise proteinuria in the cadets trained on Special Aerial Gymnastics Instruments

75%
Wochyński Z., Sobiech K.
International Journal of Occupational Medicine and Environmental Health
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2015
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vol. 28
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issue 5
863-873
EN
Objectives Assessment of the effect of training on Special Aerial Gymnastics Instruments (SAGI) on the urine β-2- microglobulin (β-2M), albumin (ALB), total protein (TP), N-acetyl-β-D-glucosaminidase EC.3.2.1.30 (NAG), expressed as creatinine (Cr) and on the physical fitness of the examined cadets in comparison with the control group. Material and Methods The study involved 55 cadets aged 20, divided into group A (N = 41) trained on SAGI, and group B (N = 14) – a control group. The urine was collected twice: before the training (BT) and after the training (AT) at the start (training I), during (training II), and after completion of the training program (training III). Urine proteins were assayed with commercially available kits. Results In group A, results obtained in trainings I, II and III showed a statistically significant increase in β-2M/Cr, NAG/Cr, TP/Cr, ALB/Cr indices in AT compared with the baseline BT values. Similarly in group B, a statistically significant increase in β-2M/Cr, NAG/Cr (trainings I, II), TP/Cr, AT compared with the baseline BT values in trainings I, II, and III was noted. Comparison of both groups showed a higher value of the post-exercise proteinuria in group B than in group A. In group A, a significant correlation between TP/Cr vs. ALB/Cr, NAG/Cr vs. TP/Cr, β-2M/Cr vs. TP/Cr, i.e., r = 0.62 at p < 0.001; r = 0.33 at p = 0.03; r = 0.60 at p < 0.001, and r = 0.52 at p < 0.001, respectively, was observed in group A, training III, AT. Conclusions Assayed urine proteins depend on the intensity of physical exercise, the type of exercise, and the level of physical fitness.
4
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The effect of occupational exposure to lead on the non-enzymatic antioxidant system

51%
Dobrakowski M., Zalejska-Fiolka J., Wielkoszyński T., Świętochowska E., Kasperczyk S.
Medycyna Pracy
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2014
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vol. 65
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issue 4
443-451
PL
Wstęp: Wpływ zatrucia ołowiem na nieenzymatyczny układ antyoksydacyjny nadal jest słabo poznany. Celem badania było określenie wpływu zawodowego narażenia na pyły ołowiu na nieenzymatyczny układ antyoksydacyjny u eksponowanych pracowników. Materiał i metody: Grupę badaną stanowiło 278 zdrowych pracowników (płci męskiej) huty cynku i ołowiu. Wyodrębniono 2 podgrupy – o niskim (stężenie ołowiu we krwi: PbB = 20–39,9 μg/dl) i wysokim narażeniu (PbB = 40–59,8 μg/dl). Do pierwszej podgrupy zakwalifikowano 129 pracowników, natomiast do drugiej z nich – 149. Grupę porównawczą stanowiło 73 zdrowych pracowników administracji, u których stężenie ołowiu oraz cynkoprotoporfiryny we krwi nie przekraczało dopuszczalnych norm (odpowiednio 10 μg/dl i 2,5 μg/g hemoglobiny). Stopień narażenia na ołów określono na podstawie stężenia ołowiu i cynkoprotoporfiryny we krwi. Ponadto oznaczono stężenia kwasu moczowego, albumin, grup tiolowych albumin, bilirubiny i α-tokoferolu. Określono także wartość tzw. zdolności redukującej osocza (ferric reducing ability of plasma – FRAP). Wyniki: Wartości biomarkerów narażenia na ołów były znamiennie wyższe w grupie badanej. Stężenie kwasu moczowego w surowicy było znamiennie wyższe w obu jej podgrupach z tendencją do wyższych wartości w podgrupie o większym narażeniu na ołów. W podgrupie tej stwierdzono także znamiennie wyższe stężenie bilirubiny w surowicy, podczas gdy w drugiej podgrupie wykazano tylko tendencję wzrostową tego parametru. Wartości FRAP nie różniły się zamiennie między grupami. Z kolei wartości pozostałych analizowanych parametrów (albuminy, grupy tiolowie albumin, α-tokoferol) były znamiennie niższe w badanych podgrupach względem grupy porównawczej. Wnioski: Zawodowe narażenie na pyły ołowiu modyfikuje funkcję nieenzymatycznego układu antyoksydacyjnego. Med. Pr. 2014;65(4):443–451
EN
Background: The role of non-enzymatic antioxidants, such as uric acid, albumin, bilirubin, and α-tocopherol, in lead poisoning remains unclear. Therefore, the aim of the study was to explore the association between occupational exposure to lead and nonenzymatic antioxidant concentrations in serum and plasma. Material and Methods: The study population consisted of 278 healthy male employees of lead-zinc plants, with 129 workers classified as having low lead exposure (blood lead level – PbB = 20–39.9 μg/dl) and 149 workers classified as having high lead exposure (PbB = 40–59.8 μg/dl). The control group was composed of 73 healthy male administrative workers. No one from this group had blood lead level or zinc protoporphyrin (ZPP) level greater than normal levels, being 10 μg/dl and 2.5 μg/g of hemoglobin, respectively. In addition to the levels of PbB and ZPP, serum levels of uric acid (UA), albumin, thiol groups of albumin, and bilirubin were determined. The ferric reducing ability of plasma (FRAP) and the plasma level of α-tocopherol were also evaluated. Results: Lead exposure indices were significantly elevated in the examined subgroups as compared with the controls. Serum uric acid levels were significantly elevated in both subgroups, particularly in the group with high exposure. Serum bilirubin concentration was significantly elevated in the group with high exposure compared with the control group, while in the group with low exposure, it showed only a non-significant trend towards an increase. In contrast, ferric-reducing ability of plasma was not significantly greater in the examined subgroups as compared with the control group. Nevertheless, levels of albumin, thiol groups of albumin, and α-tocopherol levels were significantly decreased in the exposed subgroups compared with the control group. Conclusions: Occupational exposure to lead interferes with the blood non-enzymatic antioxidant system. Med Pr 2014;65(4):443–451
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