Search results

1

Validation of the respiratory toxics exposure score (RTES) for chronic obstructive pulmonary disease screening

100%

Salameh P., Khayat G., Waked M.

International Journal of Occupational Medicine and Environmental Health

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2011

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vol. 24

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issue 4

339-347

EN

Objective: Our aim is to evaluate the validity of exhaled carbon monoxide (CO) and of a newly-created score as markers of Chronic Obstructive Pulmonary Disease (COPD). Materials and Methods: The CO level was measured in a derivation subsample of a cross-sectional study and linked to COPD diagnosis; its predictors were evaluated, and a scale was constructed. It was evaluated in a validation subsample and in a clinical setting. Results: Individuals with COPD had higher CO levels than healthy individuals. CO level signifi cant predictors were cigarettes per day, waterpipes per week, lower age, male gender, living close to diesel exhaust, heating home with the use of diesel, and having indoor family smokers. A score composed of CO predictors was able to signifi cantly predict COPD (Ora = 4–7.5). Conclusions: Coupled with the clinical judgment of physicians, this scale would be an excellent low-cost tool for screening COPD, in absence of spirometry.

2

Niewielkie, a znaczące – rola mikroRNA w powstawaniu, detekcji oraz leczeniu nowotworów na przykładzie nowotworu żołądka

89%

Jennifer Mytych J.

Medical Review

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2012

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issue 3

366–372

PL

W dobie intensywnego rozwoju chorób cywilizacyjnych, m.in. nowotworów żołądka, niezbędne jest zaprojektowanie markerów, które umożliwią wczesne ich wykrycie, pozwolą na szybkie podjęcie leczenia oraz zapobiegną zwiększeniu liczby zgonów. Taką potencjalną możliwością są mikroRNA, czyli krótkie cząsteczki RNA modulujące aktywność ściśle określonych fragmentów RNA i odgrywające szczególną rolę w wielu procesach fijologicznych i patologicznych. Wpływając na proliferację, cykl komórkowy oraz apoptozę komórek nowotworowych odgrywają znaczącą rolę również w nowotworzeniu. Wykrywalne w osoczu odstępstwa od ich normalnego poziomu, związane z każdym z etapów rozwojowych nowotworu mogą czynić je skutecznymi i nieinwazyjnymi biomarkerami, pozwalającymi nie tylko na detekcję i rozpoznawanie nowotworów, ale także na ich predykcję. Dalsze poznanie ich funkcji i właściwości może owocować odkryciem skutecznych leków do walki z nowotworami.

EN

In the era of intensive development of lifestyle diseases such as stomach cancer, it is crucial to design markers that enable their early detection, allow rapid introduction of treatment and prevent the increase in the number of deceases. Potential possibility is microRNAs, short RNA molecules which modulate the activity of specifi fragments of RNA and play an important role in many physiological and pathological processes. Affcting cell proliferation, cell cycle and apoptosis of cancer cells also play a significant role in neoplasia. Detectable levels of derogation from the regular level associated with each of the stages of tumor development may make them effctive and non-invasive biomarkers, allowing not only for early detection and identifiation of cancer’s type, but also on their prediction. Further understanding of their functions and properties can result in the discovery of effctive methods of cancer treatment.

3

Czy oznaczanie osoczowego stężenia naczyniowo- -śródbłonkowego czynnika wzrostu będzie w przyszłości wartościowym parametrem w ocenie chorych z miażdżycą tętnic kończyn dolnych w praktyce lekarza rodzinnego? – badanie pilotażowe

88%

Wieczór R., Budzyński J., Pulkowski G., Rość D.

Family Medicine & Primary Care Review

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2015

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issue 2

131-135

4

Assessment of buccal mucosa genotoxicity in insecticide-exposed urban fumigators in Cali, Colombia

75%

Londoño-Velasco E., Asencio-Santofimio H., Ortega-Avila J. G., Rosero-Caldón A. B., Aristizabal-Grisales J. C., Rey-Henao L., Vargas-Rivera J. A., Vergara-Escudero E.

International Journal of Occupational Medicine and Environmental Health

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2024

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vol. 37

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issue 1

128-137

EN

Objectives This study aimed to evaluate cytogenetic damage in the buccal mucosa of non-exposed subjects (N = 33) and insecticide-exposed fumigators (N = 31) in the urban area of Cali, Colombia. Material and Methods Through a questionnaire sociodemographic data, anthropometric measurements, state of health, and lifestyle were collected. Buccal micronucleus cytome (BMCyt) assay was using for evaluate cytogenetic damage. Results The study showed that all fumigators used adequate personal protective equipment (PPE) and had low alcohol consumption. The authors did not find significant differences in BMCyt biomarkers between the groups (p > 0.05). Multivariate analysis showed a 13% increase in micronucleus (MN) frequency for every year of increasing age (OR = 1.13, p = 0.029), and higher MN with the decrease in daily fruit consumption (OR = 4.71, p = 0.084), without statistical significance. Conclusions The results between groups could be related to healthy habits and PPE use among the subjects.

5

A spatial study on Keshan disease prevalence and selenoprotein P in the Heilongjiang Province, China

75%

Wang Y., Zhang X., Wang T., Hou J., Guo Z., Han X., Zhou H., Liang H., Xing Z.

International Journal of Occupational Medicine and Environmental Health

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2021

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vol. 34

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issue 5

659-666

EN

ObjectivesFew spatial studies on Keshan disease (KD) prevalence and serum selenoprotein P (SELENOP) levels have been reported in the Heilongjiang Province, China. This study aimed to investigate the spatial relationships between KD prevalence, SELENOP levels, and the socio-economic status for the precise prevention and control of KD.Material and MethodsThe study was carried out in all the 66 KD endemic counties in the Heilongjiang Province using a non-probability sampling method of a key village survey based on county-wide case-searching. The participants completed a questionnaire and had their serum SELENOP levels measured using enzyme-linked immunosorbent assay. Thematic maps were created, and spatial regression analysis was performed by ordinary least squares using ArcGIS 9.0.ResultsOverall, 53 676 residents were surveyed based on case-searching, and blood samples were collected from 409 residents. In total, 50 chronic KD cases were identified with a total prevalence of 9.3/10 000 population. The prevalence in the Tangyuan County was the highest (250/10 000 population). The mean serum SELENOP level was 13.96 mg/l. The spatial regression analysis showed that KD prevalence positively correlated with SELENOP levels and negatively with per capita disposable income among rural residents.ConclusionsThe Tangyuan County should be considered for the precise prevention and control of KD. Further research is necessary to verify the reliability of SELENOP for estimating body selenium levels, and to better understand the relationship between selenium intake and KD in the investigated area.

6

Salivary tumour necrosis factor-alpha and receptor for advanced glycation end products as prognostic and predictive markers for recurrence in oral squamous cell carcinoma – a pilot study

75%

Brundha M. P., Raveendran S. R., Rajeshkar N.

European Journal of Clinical and Experimental Medicine

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2023

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issue 1

36-43

EN

Introduction and aim. Tumour necrosis factor-alpha (TNF-α) belongs to the cytokine family TNF/TNFR. As a multifunctional cytokine, TNF-α plays a significant role in diverse and a variety of cellular events such as cell survival, proliferation, differentiation, and death. As a pro-inflammatory cytokine, TNF-α acts as a bridge between inflammation and carcinogenesis. Receptor for advanced glycation end products (RAGE) are cellular receptors belonging to the immunoglobulin superfamily. As one of the primary mediators of innate immunity, acute and chronic inflammatory disorders, and certain cancers, RAGE signaling plays an important role. The aim of the present study is to analyze the prognostic significance of salivary TNF-α and RAGE in oral squamous cell carcinoma. Material and methods. A study was conducted testing saliva samples collected from ten patients with well-differentiated and moderately differentiated oral squamous cell carcinomas. To determine the levels of TNF-α and RAGE in unstimulated saliva from patients, an ELISA kit from RAY BIOTECH was used for the study, and the readings were read at 450 nm. Statistical analysis was performed using SPSS software. Version 23 of SPSS was used to plot the standard curve. Statistical comparisons were done using Mann-Whitney U test and ROC analysis. Results. Salivary TNF-α and RAGE in patients were considered to be induced by radiotherapy at a higher level in moderately differentiated squamous cell carcinoma when compared to well differentiated squamous cell carcinoma. Thus, there is an increase in the induced Salivary TNF-α and RAGE levels by radiotherapy with increase in the histological stages of oral squamous cell carcinoma. The statistical analysis also proved the same. Conclusion. Hence salivary TNF-α and RAGE may be used as a biomarker for oral cancer to predict the prognosis.

7

Biometric data vulnerabilities : privacy implications

45%

Krausová A., Hazan H., Matejka J.

The Lawyer Quarterly

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2018

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vol. 8

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issue 3

295-306

EN

Biometric data are typically used for the purposes of unique identification of a person. However, recent research suggests that biometric data gathered for the purpose of identification can be analysed for extraction of additional information. This augments indicative value of biometric data. This paper illustrates the range of augmented indicative values of the data as well as identifies crucial factors that contribute to increased vulnerability of data subjects.

Refine search results

Validation of the respiratory toxics exposure score (RTES) for chronic obstructive pulmonary disease screening

Niewielkie, a znaczące – rola mikroRNA w powstawaniu, detekcji oraz leczeniu nowotworów na przykładzie nowotworu żołądka

Czy oznaczanie osoczowego stężenia naczyniowo- -śródbłonkowego czynnika wzrostu będzie w przyszłości wartościowym parametrem w ocenie chorych z miażdżycą tętnic kończyn dolnych w praktyce lekarza rodzinnego? – badanie pilotażowe

Assessment of buccal mucosa genotoxicity in insecticide-exposed urban fumigators in Cali, Colombia

A spatial study on Keshan disease prevalence and selenoprotein P in the Heilongjiang Province, China

Salivary tumour necrosis factor-alpha and receptor for advanced glycation end products as prognostic and predictive markers for recurrence in oral squamous cell carcinoma – a pilot study

Biometric data vulnerabilities : privacy implications