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The effect of chronic exercise on a biomarker of bone resorption in healthy adults

100%
Yusni Y., Rahman S.
Family Medicine & Primary Care Review
|
2019
|
issue 3
270-276
XX
Background. Long-term exercise contributes to the inhibition of osteoblast cell activity and to the decrease of bone resorption. Objectives. The research objective was to analyze the chronic effect of regular, long-term physical activity and physical inactivity on carboxyterminal collagen cross-linking telopeptide levels (CTx) and calcium levels in healthy adults. Material and methods. This study was a prospective cohort study. Fifty-four men and women, aged 17–26 years, were divided into 2 groups of 27 people each: exercise and non-exercise. This research was carried out from April 2015 to April 2016 at the Faculty of Medicine, Syiah Kuala University, Aceh, Indonesia. Bone resorption can be determined by measuring the carboxyterminal cross-linking telopeptide of collagen (CTx). The data were analyzed using Student’s t-test and regression correlation analysis with a significance level of 5%. Results. The highest levels of CTx were found in the non-exercise group; the lowest levels of CTx were in the exercise group (1.6 ng/mL and 0.30 ng/mL, respectively). This difference in CTx levels between groups was statistically significant (0.52 ± 0.22 ng/mL vs 0.72 ± 0.28 ng/mL; p = 0.005). Calcium was significantly higher in the exercise group than in the non-exercise one (9.67 ± 0.30 vs 9.01 ± 0.21 mg/dl; p = 0.006). There was a negative correlation between calcium levels and CTx in the exercise group (r = 0.038; p = 0.001). Conclusions. Regular exercise led to lower CTx levels and increased calcium levels. The increase in calcium is an effect of the decrease in CTx in healthy adults. Regular exercise decreases bone resorption and increases bone calcium
2
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Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAP kinase signaling

75%
Alfhili M. A., Alamri H. S., Alsughayyir J., Basudan A. M.
International Journal of Occupational Medicine and Environmental Health
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2021
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vol. 35
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issue 1
1-11
EN
ObjectivesNickel (Ni) is an abundant environmental hazard and an occupational pollutant. Exposure to Ni compounds is prevalent in electroplating workers and in the printing industry, among others. The toxicity of Ni manifests as dermatological, gastrointestinal, respiratory, allergic, and cardiovascular symptoms. In particular, hyperbilirubinemia and reticulocytosis have been detected in intoxicated subjects; an observation possibly implicating selective red blood cell (RBC) toxicity. Herein, the interaction of nickel chloride (NiCl2) with human RBCs and associated molecular mechanisms are described.Material and MethodsCells from healthy donors were incubated for 24 h at 37°C in the presence or absence of 0.5‒10 mM of NiCl2, and cytotoxicity was determined through hemoglobin leakage by colorimetry under different experimental conditions. Eryptotic markers were also identified by flow cytofluorometry using Annexin-V-FITC tagging for phosphatidylserine (PS) exposure, light scatter properties for cellular dimensions, Fluo4/AM labeling for intracellular calcium, and H2DCFDA staining for reactive oxygen species (ROS). Additionally, small molecule inhibitors were used to probe the signaling pathways involved.ResultsIt was found that NiCl2 at 10 mM caused profound intracellular calcium overload and significant calcium-dependent hemolysis. Also, NiCl2 reduced forward scatter and increased side scatter, Annexin-positive cells, and ROS levels. Importantly, NiCl2-induced hemolysis was significantly attenuated by the exclusion of extracellular calcium, and in the presence of p38 MAP kinase (MAPK) inhibitor SB203580.ConclusionsIt is concluded that NiCl2 induces p38 MAPK-dependent hemolysis, and stimulates the canonical features of premature eryptosis. This report presents the first description of the molecular mechanisms underlying the hemolytic and eryptotic potential of NiCl2 and, thus, may explain changes in hematological parameters observed in poisoning victims.
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Differential influence of phytase supplementation on the balance of phosphorus and other elements in laying hens’ feed

51%
Sobolewska S., Orda J., Budny-Walczak A., Paradowska M., Platje J. J.
Economic and Environmental Studies
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2015
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vol. 15
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issue 4(36)
461-468
EN
The aim of this study was to evaluate the impact of microbial phytase addition to laying hen diet on the balance of phosphorus, calcium, manganese and zinc. Phytase supplementation caused a decrease in phosphorus excretion by 8% in the group with low-phytase diet and 21% in the group with phytase addition of 1000 FTU (one unit of phytase activity) to a diet. Phytase supplementation increased the retention of phosphorus by 31% in laying hens receiving 500 FTU and 57% in the group with phytase addition of 1000 FTU to a diet, in comparison to the group without enzyme supplementation. The level of manganese in excretion was increased by 18% in the group receiving 1000 FTU phytase, and retention decreased by 24% compared with the control group. Zinc excretion was significantly increased in the group receiving 500 FTU (P ≤ 0.01) and in the group receiving 1000 FTU phytase (P ≤ 0.05). Retention of zinc was lower (P ≤ 0.01) when the birds were fed with feed containing 500 FTU and 1000 FTU phytase (P ≤ 0.05), compared with the control group. No effect on the quantity and retention of calcium excretion was found. There was no impact of phytase supplementation on egg production and egg weight.
PL
W prezentowanej pracy przedstawiono badania dotyczące wpływu dodatku fitazy mikrobiologicznej do mieszanki pełnoporcjowej przeznaczonej dla kur nieśnych na bilans fosforu, wapnia, manganu i cynku. Dodatek fitazy wpłynął na obniżenie wydalania fosforu w kałomoczu o 8% w grupie otrzymującej paszę z mniejszym dodatkiem oraz o 21% w grupie z dodatkiem 1000 FTU fitazy. Dodatek enzymu do mieszanki zwiększył także retencję fosforu o 31% u kur nieśnych otrzymujących 500 FTU i o 57% w grupie z dodatkiem 1000 FTU fitazy w porównaniu do grupy ptaków nieotrzymujących tego enzymu. Ilość fosforu wydalanego w jajach była wyrównana we wszystkich grupach i nie zaobserwowano istotnych różnic pomiędzy nimi. Kury nioski otrzymujące 1000 FTU fitazy w paszy wydalały o 18% więcej manganu w pomiocie i jednocześnie o 24% spadła jego retencja w porównaniu z grupą kontrolną. Ilość cynku wydalanego przez ptaki zwiększyła się w grupie otrzymującej 500 FTU (p ≤0.01) oraz w grupie otrzymującej 1000 FTU fitazy (p ≤0.05). Retencja cynku była niższa (p<0.01) w porównaniu z grupą kontrolną zarówno gdy ptaki żywiono paszą z dodatkiem 500 FTU fitazy, jak i w grupie dostającej 1000 FTU (p ≤0.05). Niezależnie od ilości dodatku badanego enzymu nie obserwowano jego wpływu na ilość oraz retencję wapnia wydalanego przez kury nioski. W doświadczeniu nie stwierdzono wpływu dodatku fitazy na nieśność oraz masę jaj.
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