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1

Cell therapy: a new hope for treatment of cerebral palsy ?

100%
Kułak W., Okurowska-Zawada B., Sienkiewicz D., Paszko-Patej G.
Progress in Health Sciences
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2012
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vol. 2
|
issue 2
174-180
EN
Cerebral palsy (CP) is the most frequent neurological disorder associated with perinatal injury of the developing brain. The beneficial impact of stem cells (neural stem cells, mesenchymal stem cells, and embryonic stem cells) is mediated through soluble trophic factors and other cytokines that enable the body to re-establish homeostasis after pathologic and traumatic insults, inflammation, and tissue infarction or degeneration. There is currently no effective therapy for CP. Recently there have been notable advances in the application of cell therapy in neurological disorders. This review provides recent data on the prevention and cell therapy in CP.
2
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Cell therapy for regenerative medicine: facts and controversy

88%
Sarnowska A., Machaliński B., Radoszkiewicz K., Bużańska L.
Nauka
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2021
|
issue 4
3
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Potential therapeutic application of mesenchymal stem cells in COVID-19 complications

75%
Kolanko E., Mazurski A., Czekaj P.
Medycyna Pracy
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2021
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vol. 72
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issue 6
693-700
EN
Mesenchymal stem cells (MSCs) have remarkable immunomodulatory properties, low immunogenicity, and paracrine properties as well as the ability to differentiate into multiple cell lines. These properties make them potential candidates for clinical applications in the treatment of neurodegenerative, cardiovascular, and lung diseases, which may be occupational diseases. Preclinical studies using experimental animal models have demonstrated regenerative properties of MSCs in diseases such as silicosis and occupational asthma. Currently, treatment of the novel disease COVID-19 could be enhanced by using MSC therapies. This disease affects many professional groups with great intensity and its consequences might be considered as an occupational disease. It is a significant public health problem and a therapeutic challenge. Despite the development of vaccines against COVID-19, there is growing concern about the emergence of new mutations of the SARS-CoV-2 virus in addition to the known alpha, beta, gamma, and delta variants. There is still no effective COVID-19 treatment and the existing ones only play a supporting role. MSCs offer treatment possibilities as an alternative or complementary therapy. The clinical trials to date using MSCs in patients with COVID-19 give hope for the safe and effective use of this stem cell population.
4
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Komórki macierzyste. Część III – komórki macierzyste organizmów dorosłych

51%
Bauer D., Neska J., Archacka K.
Edukacja Biologiczna i Środowiskowa
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2013
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issue 4
3-10
PL
Komórki macierzyste obecne w dorosłych organizmach są w większości komórkami uni- lub multipotencjalnymi. Ich podstawową rolą jest udział w procesach wzrostu i regeneracji tkanek, w których się znajdują. W niniejszym artykule omówiono wybrane rodzaje komórek macierzystych występujących w dorosłych organizmach, między innymi hematopoetyczne komórki macierzyste oraz mezenchymalne komórki macierzyste. Przedstawiono także informacje na temat rzeczywistego i potencjalnego zastosowania komórek macierzystych dorosłych organizmów w nauce i medycynie. Na zakończenie porównano komórki macierzyste organizmów dorosłych z komórkami pluripotencjalnymi, omówionymi w poprzedniej części cyklu.
EN
Most of the stem cells residing in adult organisms are unipotent or multipotent. These cells play the key role in the growth and regeneration of tissues. In the present article we characterized selected types of adult stem cells, inter alia hematopoietic stem cells and mesenchymal stem cells. Next, information about current and potential use of adult stem cells in science and medicine has been discussed. Finally, we summarized information about adult stem cells and pluripotent stem cells that have been described in the previous article.
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