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Primary pure squamous cell carcinoma of the gall bladder – a case report of rare and aggressive entity with adverse prognosis

100%

Mona Bargotya M., Ankita Mehta A., Payel Das P., Ashish Sachan A.

European Journal of Clinical and Experimental Medicine

2020

issue 1

59-63

Introduction. The most common malignancy of the biliary tract is gall bladder carcinoma and the main subtype according to the histological classification is Adenocarcinoma. Pure squamous cell carcinoma of the gall bladder is very rare entity accounting for only 1.1-3.7% of the gall bladder carcinomas.It is highly malignant with poor prognosis due to high proliferative rate and local invasiveness to the adjacent organs. The patients are usually diagnosed at an advanced stage with a bulky tumor owing to its aggressive behavior. Aim. In this paper, we describe a female patient with primary pure squamous cell carcinoma of the gall bladder. Description of the case. A 42-year old female patient presented with chief complaints of pain in abdomen associated with nausea and vomiting and gradually progressive jaundice since 02 months. Contrast Enhancing Computed Tomography (CECT) abdomen showed an enhancing mass lesion in gall bladder involving adjacent organs for which she underwent extended cholecystectomy with pancreaticoduodenectomy. Conclusion. Diagnosis as well as the management of this exceptionally rare type of tumour is undoubtedly challenging because of non-specific clinical as well as imaging findings. This case report is an attempt to add to the literary evidence for better pathological as well as clinical understanding of this rare and aggressive entity thereby providing additional material for the early diagnosis as well as the development of effective targeted therapies which will certainly help in increasing the lifespan of these patients.

Cancer of the gallbladder – own experience

88%

Gryko M., Dawidziuk T., Sawicka E., Cepowicz D., Kamocki Z., Masiulaniec P., Kędra B.

Progress in Health Sciences

2014

vol. 4

issue 1

153-157

Gallbladder cancer is a relatively rare cancer of the gastrointestinal tract, most commonly detected (approximately 95% of cases) in the most advanced clinical stage IV and burdened with high mortality rate. This is mainly due to the nonspecific symptoms in the early stages of the disease. The remaining cases of gallbladder cancer are usually detected after surgery due to gallstone disease. Gallstones, their size and pancreatic juice reflux into the gallbladder are risk factors in the development of gallbladder cancer. In this paper the authors carried out a retrospective research based on an evaluation of a group of 38 patients treated surgically due to the gallbladder cancer in the years 2005-2012 in the Second Department of General and Gastroenterological Surgery in Białystok Medical University Hospital. In this group there were 29 women and 9 men, in age between 48-86 years. Although women suffered from gallbladder cancer more often than men, their survival rate was significantly better after the surgery. The research showed some benefits of extended surgical procedures even in patients with advanced stages of the disease, while the effectiveness of surgical treatment depends mainly on the possibility of radical resection of the primary lesion and, eventually, the resection of lymph nodes and other infiltrated tissues.

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1 European Journal of Clinical and Experimental Medicine

1 Progress in Health Sciences

1 Ankita Mehta A.

1 Ashish Sachan A.

1 Cepowicz D.

1 Dawidziuk T.

1 Gryko M.

1 Kamocki Z.

1 Kędra B.

1 Masiulaniec P.

1 Mona Bargotya M.

1 Payel Das P.

1 Sawicka E.

1 2020

1 2014

Search results

Primary pure squamous cell carcinoma of the gall bladder – a case report of rare and aggressive entity with adverse prognosis

Cancer of the gallbladder – own experience