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1

Membrane lipids under norm and pathology

100%

Basheer Abdullah Marzoog B. A., Tatyana Ivanovna Vlasova T. I.

European Journal of Clinical and Experimental Medicine

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2021

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issue 1

59-75

EN

Introduction. Lipid is an essential component of the cell and its organelles membrane. The uniqueness and selectivity of lipids to specific functions and asymmetry of lipid distribution in the organelle’s membrane give the cell ability of being highly qualified and specified. Aim. The paper provides a comprehensive review of membrane lipids in different tissues and organelles of the cell in norm and disease. Material and methods. The paper analyzed the present literature data on membrane lipids behavior in physiology and pathology. Analysis of the literature. The major structural and functional lipids of the cell membrane are phosphatidylcholine > phosphatidylethanolamine. The absence/deficiency or augmentation of a specific type of lipid results in serious defects and usually life-threatening with a permanent disability. The observations discussed here suggest, the lipid peroxidation severity depends on the membrane lipid composition of the cell. Some tissue cells can handle lipoperoxidation and protect themselves from the peroxidation damaging products better, while other cells cannot compensate. Therefore, some organs are highly sensitive to peroxidation and irreversible changes occur rapidly. Conclusion. To sum up, the understanding of lipid’s role in norm and disease is clinically crucial to evaluate a novel therapeutic target to treat many metabolic disorders such as metabolic syndrome and some lysosomal storage disorders via targeting specific new signaling pathways, lipid molecules, and enzymes

2

Analiza częstości występowania poszczególnych zaburzeń lipidowych wśród pacjentów z rozpoznaną dyslipidemią

100%

Gwiazda E., Mastalerz-Migas A., Szyber P.

Family Medicine & Primary Care Review

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2014

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issue 2

101-102

PL

Wstęp. Choroby sercowo-naczyniowe odpowiadają za 45% zgonów w Polsce. Umierają na nie głównie osoby po 65. roku życia, ale są obecne już u osób znacznie młodszych. ajczęstszym czynnikiem ryzyka chorób sercowo-naczyniowych jest dyslipidemia. Cel pracy. Oszacowanie częstości występowania poszczególnych rodzajów zaburzeń lipidowych przed rozpoczęciem leczenia wśród pacjentów z rozpoznaną dyslipidemią w zależności od wieku. Materiał i metody. Badanie przeprowadzono na podstawie wypełnionych przez lekarzy pracujących w opiece ambulatoryjnej w Polsce anonimowych kwestionariuszy dotyczących dorosłych pacjentów z rozpoznaną dyslipidemią. Do badania akwalifikowano 23 136 pacjentów. Badanie przeprowadzono w latach 2009–2010. Wyniki. Nieprawidłowe stężenie cholesterolu całkowitego (TC) przed rozpoczęciem leczenia wykazano u 94% osób z podanymi wartościami parametru, LDL -C odpowiednio u 91,5%, HDL -C – u 37%, natomiast trójglicerydów (TG) – u 68,1%.TC najczęściej zaburzony był w grupie osób < 45. r.ż., LDL -C w grupie wiekowej 45–54 lata, HDL -C u osób < 65. r.ż., a T G w grupie 55–64 lata. Wnioski. Stężenia poszczególnych składowych lipidogramu zależą od wieku. Najbardziej zintensyfikowane działania, mające na celu identyfikację osób z dyslipidemią i ich skuteczne leczenie, powinny być skierowane do osób poniżej 65. r.ż.

3

Prolonged consumption of energy drinks does not affect the processes of memory, and increases the activity of transaminases, and cholesterol concentration – animal model study results

100%

Nieradko-Iwanicka B., Pietraszek D., Pośnik K.

Family Medicine & Primary Care Review

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2016

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issue 3

313-316

4

Preferencje żywieniowe pacjentów z chorobami układu krążenia

100%

Korzeniowska-Ginter R., Komorowska-Szczepańska W., Stasiak-Szelągiewicz

Family Medicine & Primary Care Review

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2013

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issue 2

124-126

5

Częstość występowania czynników ryzyka chorób układu krążenia w populacji pacjentów z nadciśnieniem tętniczym leczonych w praktykach lekarzy rodzinnych i POZ – wyniki badania POZ-NA D

88%

Mastalerz-Migas A., Pokorna-Kałwak D., Steciwko A., Januszewicz A., Opolski G.

Family Medicine & Primary Care Review

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2011

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issue 2

181-184

6

Efficacy of Lepidium Sativum to act as an anti-diabetic agent

75%

Mishra N., Mohammed A., Rizvi S.

Progress in Health Sciences

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2017

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vol. 7(1)

44-53

EN

Objective: Lepidium sativum, commonly known as chandrashoor in India, has been used in the Indian traditional medicine system for the treatment of various diseases. The present study was undertaken to investigate the hypoglycemic effect of Lepidium sativum in normal and streptozotocin-induced diabetic rats. Materials and methods: Thirty (30) adult male Wistar rats weighing 157±51g were randomly assigned to five groups of six rats each as Normal control, Diabetic control, Diabetics supplemented with Lepidium sativum extract, Diabetics treated with insulin, and Normal rats supplemented with Lepidium sativum. All rats were fed with a normal laboratory diet, nutrient rich pellets, and had free access to drinking water. The rats were injected with streptozotocin at a dose of 45 mg/kg body weight intraperitoneally to induce diabetes. The extracts were then given orally to different groups of rats at a dose of 20mg/kg body weight for 16 days. Thereafter, the rats were sacrificed, and blood samples collected by cardiac puncture were used for the determination of Glucose, Creatinine, Alkaline Phosphatase, Cholesterol, Malondialdehyde level, % DPPH, and FRAP content. Results: Administration of lepidium extract showed a significant reduction in glucose, creatinine, and alkaline phosphatase levels. Elevated cholesterol level was restored approximately to normal; a significant decrease in malondialdehyde levels was also observed compared to diabetic controls. Conclusion: Lepidium sativum extract shows efficacy in the prevention and management of diabetes mellitus and its related complications.

7

Anthropometric indicators as predictors of the risk of metabolic syndrome in adult working men

75%

Brudecki J., Chrzanowska M.

Anthropological Review

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2015

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vol. 78

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issue 1

67-77

EN

Measurement of body weight, height, waist and hip circumference is a standard procedure that allows to better define the risk of metabolic syndrome. The aim of the study is to determine the usefulness of anthropometric indicators such as BMI, WC (waist circumference), WHR, WHtR and percentage of body fat to predict the metabolic cardiovascular risk in the adult male population of Krakow, as well as an attempt to determine the metabolic cardiovascular risk with the original anthropometric risk index. The study included 405 men from the population working in the T. Sendzimir Steelworks in Kraków at the age of 30-69 years. Anthropometric measurements: body height measured to the nearest mm, circuits (waist, hips) measured to the nearest centimetre, the percentage of fat (the type of electronic scales Tanita BF 300) measured according to the standard protocol by the same technician and biomedical indicators assessing the functional status of organism, total cholesterol, HDL, LDL, triglycerides, glucose and blood pressure measured with a mercury manometer. As a measure of goodness of fit for the indices of risk (and their components), the AUC method was used for the ROC curves to evaluate the sensitivity and specificity of the diagnostic test. The results show that significant in predicting the risk of metabolic syndrome are not only standard anthropometric measurements specified in the standards of WHO, EGIR, NCEP and IDF. In addition, it is important to take into account the amount of fat and calculate the cumulative risk index based on all relevant measurements and indicators.

8

Associations of nutrition and body composition with cardiovascular disease risk factors in soldiers during a 6-month deployment

75%

Nykänen T., Pihlainen K., Kyröläinen H., Fogelholm M.

International Journal of Occupational Medicine and Environmental Health

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2020

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vol. 33

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issue 4

457-466

EN

ObjectivesThis observational follow-up study investigated the associations of nutrition and body composition with cardiovascular disease (CVD) risk factors, including pro-inflammatory biomarkers, in soldiers during a 6-month deployment.Material and MethodsThirty-five male soldiers were assessed at months 0, 3 and 6, and their parameters, i.e., M±SD, were as follows: age 30.0±8.7 years, height 179±6 cm, and BMI 24.2±2.5 kg/m2. Three-day food diaries were used for monitoring macronutrient intake. Body composition was estimated using bioimpedance. Fasting blood samples for lipids and pro-inflammatory biomarkers were collected, and blood pressure measurements were performed.ResultsCarbohydrate intake increased and protein intake decreased at month 3 (p = 0.034, p < 0.001), while body composition remained stable. Systolic blood pressure increased at month 6, while other CVD risk factors remained within the reference values. Fat mass and body fat percentage were associated positively with total and low density lipoprotein (LDL) cholesterol concentrations at all measurement points. A negative association was found between the change in fiber intake vs. the change in total (r = –0.36, p = 0.033) and LDL cholesterol (r = –0.39, p = 0.019).ConclusionsLower fiber intake and a greater amount of body fat were associated with high total and LDL cholesterol concentrations. Nevertheless, the measured CVD risk factors remained within the reference values, except for the higher systolic blood pressure. A regular screening of body composition and a higher consumption of fiberrich foods may promote cardiometabolic health in soldiers.

9

Hypercholesterolemia and prevention of cardiovascular diseases in the light of preventive medical examinations of employees in Poland

75%

Śliż D., Marcinkiewicz A., Olejniczak D., Jankowski P., Staniszewska A., Mamcarz A., Walusiak-Skorupa J.

International Journal of Occupational Medicine and Environmental Health

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2019

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vol. 32

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issue 6

865-872

EN

Long-term exposure to hypercholesterolemia is the cause of atherosclerosis, which in turn causes cardiovascular and cerebrovascular events. In developed countries, including Poland, vascular diseases are the main cause of death. They affect an ever younger part of the population, including the working population. The authors address the problem of epidemiology of cardiovascular diseases, unsatisfactory detection and treatment, economic consequences for the health care system, and the possibilities of using occupational medicine services in the prevention of this health problem. Due to the fact that the early detection of diseases caused by high blood cholesterol levels is relatively low in Poland, obligatory occupational medicine examinations seem to be a key element of the second-line prevention. Therefore, it seems natural to consider the idea of extending the scope of obligatory examinations and introducing tests that allow lipid disorders to be detected at an early stage. This can contribute to a general improvement of the health of the population, and to economic benefits, such as a decrease in the costs of treatment of the disorders that have been detected too late. Broadening the scope of occupational examinations is also important from the perspective of public health and epidemiology of cardiovascular diseases, thus being an element of prevention of civilization diseases. It means improving health and building health awareness, and it should translate into regular health examinations. The performance of these examinations should result not only from the obligation, but also from the patient’s conviction about the importance of early detection of disorders, including lipid disorders, for an effective therapy. Int J Occup Med Environ Health. 2019;32(6):865–72

Refine search results

Membrane lipids under norm and pathology

Analiza częstości występowania poszczególnych zaburzeń lipidowych wśród pacjentów z rozpoznaną dyslipidemią

Prolonged consumption of energy drinks does not affect the processes of memory, and increases the activity of transaminases, and cholesterol concentration – animal model study results

Preferencje żywieniowe pacjentów z chorobami układu krążenia

Częstość występowania czynników ryzyka chorób układu krążenia w populacji pacjentów z nadciśnieniem tętniczym leczonych w praktykach lekarzy rodzinnych i POZ – wyniki badania POZ-NA D

Efficacy of Lepidium Sativum to act as an anti-diabetic agent

Anthropometric indicators as predictors of the risk of metabolic syndrome in adult working men

Associations of nutrition and body composition with cardiovascular disease risk factors in soldiers during a 6-month deployment

Hypercholesterolemia and prevention of cardiovascular diseases in the light of preventive medical examinations of employees in Poland