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EN
ObjectivesExposure to light at night (LAN) can disturb circadian endocrine and metabolic rhythms. Hyperuricemia (HUA) is an early-onset metabolic disorder. However, it is still not clear whether LAN exposure increases the prevalence of HUA.Material and MethodsThe authors used crosssectional data on the Beijing-Tianjin-Hebei occupational populations cohort from March–July 2017. A total of 7664 steel workers were finally selected to investigate the relationship between LAN exposure and the prevalence of HUA among steel workers. The authors collected demographic and socio-economic data, as well as information on lifestyle factors, anthropometric measures, and laboratory tests. The restricted cubic spline method was used to analyze the dose-response relationship between cumulative LAN exposure and the prevalence of HUA. Logistic regression analyses were used to fit the relationship between them.ResultsThe average age of the participants was 43.5±8.6 years; 7051 (91.7%) of them were males, 2749 (35.9%) reported to suffer from HUA, and 1241 (16.2%) were not exposed to LAN. There was a significant non-linear dose-response relationship between them. After adjustment for the confounding factors, including demographic data, lifestyle factors, etc., the lower LAN exposure was significantly associated with HUA (0–1931.7 days, OR = 1.180, and the 95% CI: 1.000–1.394; 1931.7–4343 days, OR = 1.215, 95% CI: 1.035–1.426).ConclusionsThis study revealed that a certain amount of exposure to LAN is independently related to the prevalence of HUA in steel workers in China.
EN
The shift work system may affect the temporal distribution of eating and diet quality. The paper aimed at reviewing a body of research examining the associations between night shift work and dietary habits among nurses. Data from the PubMed and Google Schoolar databases, as well as references lists in selected papers were searched. The authors used the following keywords: nurses, shift work, diet, nutrition. Papers published in English or Polish were selected for the review, and as many as 19 papers published in 2000−2017 were eventually identified. The studies varied greatly with respect to the study size, subjects’ age and the duration of night shift work. The major problem was the heterogeneity of the tools used for dietary assessment. Self-administered questionnaires were used and analyses were rarely adjusted for confounders. Alcohol consumption was the most frequently analyzed aspect (N = 8 studies), followed by the total energy (N = 7), protein, fat (N = 6), and carbohydrate intake, coffee and fruit consumption (N = 5). The results showed quite a consistent association of night work with higher coffee (caffeine) consumption, as well as lower alcohol, and fruit and vegetables consumption. Few studies also reported more frequent snacks consumption, later time of the last meal, eating at night, meals irregularity, and a poorer diet quality among night shift nurses when compared to the reference. The review showed some poor nutritional habits among nurses working night shifts. However, the topic warrants further attention, owing to the relatively small number of the studies performed so far, and their numerous methodological limitations. Med Pr. 2019;70(3):363–76
EN
Schizotypy is a disorder belonging to schizophrenia spectrum and characterized, among others, by a tendency to eccentric behavior, magical thinking and unusual experiences. The features of schizotypy are more intensive in bipolar affective illness, compared to healthy persons. This study assesses an association between polymorphisms of genes of dopaminergic systems and of circadian rhythms and dimensions of schizotypy measured by the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE), in patients with bipolar affective illness. Seventy patients with bipolar affective illness (21 males, 49 females), aged 59±12 years, treated at outpatient clinic Department of Adult Psychiatry, Poznań University of Medical Sciences were included in the study. In all patients, the O-LIFE, 43 question version, was used measuring such dimensions of schizotypy as unusual experiences, cognitive disorganisation, introvertive anhedonia and impulsive nonconformity. Genotyping was performed for polymorphisms of the COMT, DAT, DRD2, DRD3 and DRD4 genes of dopaminergic system and for the CLOCK, ARNTL, TIM and PER3 genes of circadian rhythms. Among genes of dopaminergic system, an association with dimensions of schizotypy was obtained with the COMT, DRD2, DRD3 and DRD4 genes, and among genes of circadian rhythms with polymorphisms of the ARNTL gene. After Bonferroni correction, a significant association remained between dimension of cognitive disorganisation and rs4680 polymorphism of the COMT gene, rs6280 polymorphism of the DRD3 gene and rs1481892 polymorphism of the ARNTL gene, as well as between dimension of unusual experiences and rs7937060 polymorphism of the ARNTL gene. The results obtained confirm a genetic association between dimensions of schizotypy, especially those connected with psychoticism, and dopaminergic system, in patients with bipolar affective illness. In this paper, for the first time, an association of schizotypal features with polymorphism of the ARNTL gene, one of the most important gene of circadian rhythms, was demonstrated.
PL
Schizotypia jest zaburzeniem z kręgu spektrum schizofrenii charakteryzującym się, m.in. tendencją do ekscentrycznych zachowań, myśleniem magicznym i niezwykłymi doznaniami. Cechy schizotypii występują również w większym nasileniu w chorobie afektywnej dwubiegunowej (ChAD) w porównaniu z osobami zdrowymi. Celem niniejszej pracy była ocena asocjacji między polimorfizmami genów układu dopaminergicznego oraz rytmów około dobowych, a wymiarami schizotypii mierzonymi w skali Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) u pacjentów z ChAD. W badaniu wzięło udział 70 pacjentów z ChAD (21 mężczyzn i 49 kobiet) w wieku 59±12 lat, z Poradni Przyklinicznej Kliniki Psychiatrii Dorosłych UM w Poznaniu. U wszystkich przeprowadzono badania kwestionariuszem O-LIFE, wersja 43 pytań, mierzącym takie wymiary schizotypii, jak niezwykłe doznania, dezorganizacja poznawcza, introwersja i anhedonia oraz zachowania impulsywne i niezgodne z regułami. U pacjentów wykonano genotypowanie polimorfizmów genów układu dopaminergicznego: genu COMT, DAT, DRD2, DRD3 i DRD4 oraz genów rytmów okołodobowych CLOCK, ARNTL, TIM, PER3. Wśród genów układu dopaminergicznego asocjację z wymianami schizotypii stwierdzono w odniesieniu do genów COMT, DRD2, DRD3 i DRD4, a w zakresie genów rytmów okołodobowych z polimorfizmami genu ARNTL. Istotna asocjacja po zastosowaniu korekty Bonferroniego utrzymała się między wymiarem „dezorganizacja poznawcza” a polimorfizmem rs4680 genu COMT, polimorfizmem rs6280 genu DRD3 oraz polimorfizmem rs1481892 genu ARNTL, jak również między wymiarem „niezwykle doznania” a polimorfizmem rs7937060 genu ARNTL. Uzyskane wyniki potwierdzają genetyczny związek wymiarów schizotypii, zwłaszcza dotyczących „psychotyczności” z układem dopaminergicznym u pacjentów z ChAD. W niniejszej pracy po raz pierwszy wykazano u pacjentów z ChAD związek cech schizotypii z polimorfizmem genu ARNTL, jednego z najważniejszych genów dotyczących rytmów dobowych.
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