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1

Agenesis of corpus callosum: genetics, epidemiology and neuroimaging findings

100%
Gościk E., Kułak P.
Progress in Health Sciences
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2011
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vol. 1
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issue 2
126-131
EN
Agenesis of the corpus callosum (ACC), a failure to develop the large bundle of fibres that connect the cerebral hemispheres, occurs in 1:4000 individuals. It is characterized by a partial or complete absence (agenesis) of an area of the brain that connects the two cerebral hemispheres. The cause of ACC is usually not known, but it can be inherited as either an autosomal recessive trait or an X-linked dominant trait. It can also be caused by an infection or injury during the twelfth to the twenty-second week of pregnancy leading to developmental disturbance of the fetal brain. Intrauterine exposure to alcohol can also result in ACC. In some cases mental retardation may result, but intelligence may be only mildly impaired and subtle psychosocial symptoms may be present. Prognosis varies depending on the type of callosal abnormality and associated conditions or syndromes. Online searches of the databases EMBASE, PubMed, and Medline were performed, using the search terms children, corpus callosum, agenesis, absence, genetics, and neuroimaging. In this article, we presented genetics, epidemiology, and neuro-imaging of ACC for the last decade
2

Abnormalities of the corpus callosum: Magnetic resonance imaging analysis in children

100%
Kułak P., Gościk E., Śmigielska-Kuzia J.
Progress in Health Sciences
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2012
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vol. 2
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issue 2
57-63
EN
Purpose: This study reports the clinical profile of children with abnormalities of the corpus callosum in magnetic resonance imaging (MRI). Materials and methods: Children with agenesis of the corpus callosum (ACC), hypoplasia, and dysgenesis were identified in a database of patients at the Department of Pediatric Radiology. Medical records were then systematically reviewed. Twenty brain MRI scans of children with abnormalities of the corpus callosum were chosen randomly and retrospectively analyzed. We also analyzed age, gender, motor development, mental development, epilepsy, and concomitant disorders. Results: The study group was composed of 20 children with various disorders (11 girls, 9 boys). The ages of the children ranged from 4 months to 17 years, with a mean age of 9.8 years. Almost all children were born at term. More than half of patients 11(55%) had ACC, 6 children had hypoplasia of the corpus callosum hypoplasia and 3 patients had an absence of genu of the corpus callosum or splenium. Nine children had mental retardation. Four patients had hydrocephalus and two had meningomyelocele, while two patients had Dandy-Walker syndrome and one had holo-prosencephaly. Three patients had headache. One patient had tics syndrome and one Attention deficit-hyperactivity disorder. Fifteen children had normal motor development, with three using a wheelchair, and two unable to sit and walk. Three patients had epilepsy. Conclusion: A spectrum of clinical presentations is apparent in children with abnormalities of the corpus callosum.
3
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Disruption of verbal communication in children and adolescents with congenital corpus callosum on the background of communication disorders of persons with mild intellectual disabilities and dyslexia – the report based on own research

100%
Boksa E.
Logopedia
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2014-2015
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vol. 43-44 EN
361-372
EN
In the article, language communication disorders in children with agenesis or hypoplasia of the corpus callosum will be discussed. The functional diagnosis of speech therapy should take into account the fact that the reported symptoms and communication disturbance in patients with damage or hypoplasia of the corpus callosum correlate with language disorders on many levels, wherein damage to the right hemisphere of the brain is the basis. The similarity of the symptoms of language disorders in patients with corpus callosum defect can also be seen in dyslexia or oligophasia (in persons with mild intellectual disability). Therefore, the process of therapeutic programming needs to involve preparation of speech differential diagnosis based on the most recent neurological, neuropsychological and neurobiological data. The differential diagnosis and treatment program for patients/ students with hypoplastic of CC (corpus callosum) is included in the revision of the traditional view of the role of each of the cerebral hemispheres in acquisition and development of language. The author takes the view that in the course of language acquisition first of all cooperation between the hemispheres, the foundation of which is working corpus callosum, is of crucial importance.
4
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Zakłócenia komunikacji językowej u dzieci i młodzieży z wadą ciała modzelowatego na tle zaburzeń komunikacji osób z dysleksją oraz niepełnosprawnością intelektualną w stopniu lekkim – doniesienie z badań własnych

63%
Boksa E.
Logopedia
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2014-2015
|
vol. 43-44
383-395
PL
W artykule omówione zostały zaburzenia komunikacji językowej u dzieci z agenezją lub hipoplazją ciała modzelowatego. W funkcjonalnej diagnozie logopedycznej należy uwzględnić fakt, że przedstawione objawy zakłóceń komunikacyjnych u osób z uszkodzeniem lub niedorozwojem ciała modzelowatego korelują na wielu płaszczyznach z zaburzeniami komunikacji językowej, których podłoże stanowi uszkodzenie prawej półkuli mózgu. Podobieństwo symptomów zaburzeń językowych u osób z wadą ciała modzelowatego można dostrzec także w dysleksji lub oligofazji (u osób z lekką niepełnosprawnością intelektualną). Zatem w procesie programowania terapeutycznego niezbędne jest dokonanie logopedycznej diagnozy różnicowej w oparciu o najnowsze dane neurologiczne, neurobiologiczne i neuropsychologiczne. Diagnoza różnicowa oraz programowanie terapii w przypadku pacjentów/uczniów z niedorozwojem CC (corpus callosum) osadza się na rewizji tradycyjnego poglądu na rolę każdej z półkul mózgowych w procesie nabywania i rozwoju języka. Autorka artykułu reprezentuje pogląd, że w toku akwizycji języka istotna jest przede wszystkim współpraca międzypółkulowa, której fundamentem jest sprawne ciało modzelowate.
EN
In the article – will be discussed language communication disorders in children with agenesis or hypoplasia of the corpus callosum. The functional diagnosis of speech therapy should take into account the fact that the reported symptoms and communication disturbance in patients with damage or hypoplasia of the corpus callosum on many levels correlate with language disorders, wherein the substrate is damage to the right hemisphere of the brain. The similarity of the symptoms of language disorders in patients with corpus callosum defect can also be seen in dyslexia or oligophasia (in people with intellectual disability light). Thus, in the process of therapeutic programming is necessary to make speech therapy differential diagnosis based on the most recent neurological, neurobiological and neuropsychological. Differential diagnosis and treatment program for patients / students with hypoplastic CC (corpus callosum) is deposited on the revision of the traditional view of the role of each of the cerebral hemispheres in the acquisition and development of language. The author takes the view that in the course of language acquisition is important above all cooperation reconcile cross, which the foundation is working corpus callosum.
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