Search results

1

Complex relationships between endocrinopathies and obstructive sleep apnea syndrome

100%

Monika Szymańska M., Grzegorz Mizerski G., Paweł Kiciński P.

European Journal of Clinical and Experimental Medicine

|

2017

|

issue 3

268-272

EN

Sleep-related disordered breathing (SRDB) is a term covering a heterogeneous group of conditions with a similar clinical picture yet different pathogenesis. Nocturnal episodes of obstructive apnoea, leading to repeated periods of desaturation and re-oxygenation, activate chemoreceptors and increase the activity of the sympathetic as well as renin-angiotensin-aldosterone system. Moreover, the generation of free radicals and proinflammatory cytokines increases. All the above mentioned disturbances interfere with the function of endocrine glands. On the other hand, many endocrine disorders are associated with an increased risk of obstructive sleep apnoea syndrome (OSAS). In this paper, we discuss relationships between selected endocrinopathies and OSAS.

2

An analysis of the level of knowledge about diabetes among pregnant women

80%

Buraczewska E., Sokołowska B., Mazurkiewicz B., Borzęcki A.

Family Medicine & Primary Care Review

|

2016

|

issue 3

225-229

3

Influence of food-derived advanced glycation end products on health

80%

Sabina Galiniak S., Marek Bieiadecki M.

European Journal of Clinical and Experimental Medicine

|

2018

|

issue 4

330-334

EN

Introduction. Advanced glycation end products (AGEs) are compounds formed endogenously in the human body. Besides this source of AGEs, they also exist in food and can be generated during cooking. Enhanced endogenous generation and intake of dietary AGEs have physiological impact on human health and are associated with progression of many diseases, including diabetes and its complications. Aim. The purpose of this review is to the present the current state of knowledge about the various negative effects of advanced glycation end products on human health. Materials and methods. This study is based on analysis of literature reporting the content of AGEs in food and high or low AGEs dietary interventions in human and animal subjects. Results. Literature data present databases gathering description of AGEs determinations in various types of food. Conclusions. Excessive consumption of AGEs-rich products, especially abundant in protein and fat or cooked for a long time at high temperature, may contribute to the deterioration of human health, including development of hypertension, insulin resistance, and diabetic complications.

4

Glucagonoma as a rare case of neuroendocrine tumor of the pancreas: a case report

80%

Zińczuk J., Lewoniewska S., Zaręba K., Pryczynicz A., Guzińska-Ustymowicz K.

Progress in Health Sciences

|

2019

|

vol. 1

169-173

EN

Introduction: Glucagonoma is a rare neuroendocrine tumor with characteristic features such as the presence of the glucagon-producing tumor, diabetes, and necrolytic migratory erythema. Case presentation: the 60-year-old patient was admitted to hospital with periodic pain in the right and middle upper abdominal appearing after eating. Laboratory tests presented a high glucose level and anemia. Tumor of the body and tail of the pancreas passing the organ pouch has been found during the surgery. Diagnosis of glucagonoma was confirmed in histopathological examination in immunohistochemical stainings: a positive reaction was observed with chromogranin, synaptophysin and CEA. The proliferative activity of Ki-67 was less than 1%. Staining for glucagon also was positive so confirmed the presence of neuroendocrine tumor - glucagonoma. Conclusions: Glucagonoma sometimes may occur without characteristic features which may cause delayed diagnosis. Early diagnosis of glucagonoma is important because it increases the chances of successful recovery.

5

An evaluation of the prevalence of autoimmunological diseases in patients with diabetes and obesity hospitalized in the Department of Diabetology, Rural Medicine Institute in Lublin

80%

Szcześniak G., Zdybel W., Kozak-Nurczyk P., Dziemidok P.

Family Medicine & Primary Care Review

|

2016

|

issue 3

345-347

6

What next for diabetes mellitus?

80%

Witek B., Rochon-Szmejchel D., Kamińska D.

Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia

|

2016

|

issue Annales Universitatis Paedagogicae Cracoviensis Studia ad Didacticam Biologiae Pertinentia VI (2016)

6-19

7

Potoczna wiedza o cukrzycy: porównanie osób posiadających i nieposiadających chorego na cukrzycę w rodzinie

80%

Olchowska-Kotala A., Zakład Humanistycznych Nauk Lekarskich W. L.

Acta Universitatis Lodziensis. Folia Psychologica

|

2012

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vol. 16

EN

The aim of the study was to examine the perception of diabetes and the knowledge about this disease. Participants were divided into two groups: the first one consisted of family members of diabetic patients (56 individuals; M age = 54) whereas the second one comprised those who had no family experiences with diabetes (104 individuals; M age = 55). In order to examine the perception of diabetes modified version of IPQ-R (The Revised Illness Perception Questionnaire), enabling examination of healthy individuals was applied. Additionally, participants were to decide whether certain given information on diabetes was true or false. Participants in both groups considered diabetes as a serious chronic disease which can be successfully treated and the course of which is largely dependent on a patient’s behaviour. In both groups there were false assumptions regarding the causes of the disease and opinions discordant with medical knowledge. It would be advisable to organize educational campaigns and screening programmes for the family members. As a result, family members would be able to provide better support for the patient and could also recognize dysfunctions of their own organism early enough.

8

Association between a nucleotide polymorphism in the calpain 10 gene and carbohydrate metabolism disturbances in patients with polycystic ovary syndrome

80%

Szydlarska D., Machaj M.

Family Medicine & Primary Care Review

|

2016

|

issue 4

497-500

9

Disorders of carbohydrate metabolism and their relationship with the prevalence of cancer in patients with acromegaly – authors’ own observations

80%

Malicka J., Kurowska M., Dudzińska M., Smoleń A., Oszywa-Chabros A., Tarach J.

Family Medicine & Primary Care Review

|

2016

|

issue 3

291-293

10

Wpływ stylu zachowania na jakość życia chorych z cukrzycą, poziom samoopieki oraz parametry kliniczne.

80%

Fabich E.

Współczesne Pielęgniarstwo i Ochrona Zdrowia

|

2019

|

issue 1

10-14

PL

Wstęp. Przewlekła hiperglikemia w cukrzycy wiąże się z występowaniem odległych powikłań, zaburzeniami funkcji i niewydolnością niektórych narządów, szczególnie oczu, nerek, serca oraz powikłaniami ze strony układu nerwowego i naczyń krwionośnych. Cukrzyca występuje z różnym natężeniem we wszystkich rasach, populacjach i w każdym wieku.

EN

Background. Chronic hyperglycemia in diabetes is related w ith long-term complications, functional disorder and insufficiency of some organs, in particular eyes, kidneys, heart and complications related to the nervous system and blood vessels. Diabetes occurs with the different intensity in all races, populations and at every age.

11

Rys historyczny badań nad doustnymi lekami przeciwcukrzycowymi z klasy gliflozyn

80%

Stelmaszyk A.

Acta Medicorum Polonorum

|

2016

|

vol. 6

|

issue 1

41-59

PL

Artykuł przedstawia historię odkrycia nowych leków przeciw cukrzycy typu 2, tzw. gliflozyn. Badania nad nimi prowadzone były w ciągu ostatniego półwiecza. Wykorzystano w nich związek wyizolowany z korzeni jabłoni w 1835 r. i odkryte w 1961 r. tzw. kotransportery. Wykazano, jakie glifozyny odkryto w latach 1999-2012. Przedstawiono zalety i wady tych drogich i nie refundowanych w Polsce leków.

EN

This article presents how new medicines against diabetes type 2, so called gliflozines, were discovered. Research on gliflozines were carried out during last fifty years. A chemical compound isolated in 1835 from the root of apple tree and discovered in 1961 so called membrane co-transporters were used in these experiments. The article shows which gliflozines were discovered in 1999-2012. Strong points and faults of these non-refundable in Poland medicines are described.

12

Estimating the confidence interval of the regression coefficient of the blood sugar model through a multivariable linear spline with known variance

80%

Islamiyati A., Raupong R., Kalondeng A., Sari U.

Statistics in Transition new series

|

2022

|

vol. 23

|

issue 1

201-212

EN

Estimates from confidence intervals are more powerful than point estimates, because there are intervals for parameter values used to estimate populations. In relation to global conditions, involving issues such as type 2 diabetes mellitus, it is very difficult to make estimations limited to one point only. Therefore, in this article, we estimate confidence intervals in a truncated spline model for type 2 diabetes data. We use a non-parametric regression model through a multi-variable spline linear estimator. The use of the model results from the irregularity of the data, so it does not form a parametric pattern. Subsequently, we obtained the interval from beta parameter values for each predictor. Body mass index, HDL cholesterol, LDL cholesterol and triglycerides all have two regression coefficients at different intervals as the number of the found optimal knot points is one. This value is the interval for multivariable spline regression coefficients that can occur in a population of type 2 diabetes patients.

13

Poverty, Obesity, Diabetes: Are They the By-Products of Liberalization of Global Economy?

70%

Rehman S. N.

Annales. Etyka w Życiu Gospodarczym

|

2016

|

vol. 19

|

issue 4

39-49

PL

-

EN

The paper briefly describes the causes of a global rise in obesity and diabetes. In so doing, it establishes links between (1) poverty and obesity, and (2) obesity and diabetes. The paper also presents data from a survey (N=147) conducted in a depressed economy in Texas where cases of obesity and diabetes are among the highest in the US. The paper argues for a paradigm shift in viewing the role of policymakers in regards to food and pharmaceutical industries, both locally and globally.

14

Porównanie form prowadzenia dzienniczka samokontroli cukrzycy w kontekście zarządzania wiedzą pacjentów i podnoszenia jakości samokontroli

70%

Perkowski B.

e-mentor

|

2013

|

issue 2 (49)

49-54

EN

Knowledge management in the healthcare sector encompasses collecting data on a patient’s disease. The method of collecting information affects the quality and efficiency of data processing by providing relevant results. The article compares different ways of diabetes management to support their self-care, and their measurable results. The purpose of this article is to demonstrate how various forms of diabetes management affect patients’ knowledge and contribute to the improvement of diabetes treatment.

15

Prevalence of depression in Indian patients with type 2 diabetes mellitus and/or hypertension: DEPTH Study

70%

Raj Kumar Lalwani R. K., Jayesh Dashrathlal Shah J. D., Tapas Chatterjea T., Papa Rao Nadakuduru P. R., Suhas Erande S.

European Journal of Clinical and Experimental Medicine

|

2019

|

issue 4

315-325

EN

ABSTRACT Introduction. Depression, a common psychiatric mood disorder, is a leading cause of disability and a significant contributor to the overall global burden of disease. Aim. To determine the prevalence of depression in patients with controlled and uncontrolled type-2 diabetes mellitus (T2DM) and/or hypertension (HTN) in India. The association of depression with socio-demographic profile and clinical risk factors was also assessed. Material and methods. In this cross-sectional epidemiological study, T2DM and/or HTN patients attending outpatient department at tertiary care hospitals and private clinics across 54 cities in India were enrolled. The primary outcome measure was to determine the prevalence of depression in T2DM, HTN and T2DM + HTN patients. Association of depression with patients’ demography, socio-economic status, anxiety, and clinically diagnosed insomnia were also investigated. Results. Of 1829 patients, the prevalence of depression in T2DM, HTN and T2DM+HTN cases were found to be 51.03%, 46.94% and 48.64%, respectively. A higher proportion of patients with uncontrolled T2DM and HTN reported depression (T2DM: 77.64% vs. 22.36%; HTN: 72.49% vs. 27.51%). There was a significant association between anxiety and severity of depression across all indications (p<0.0001). Depression was significantly associated with complications in T2DM (p=0.0001) and comorbidities in T2DM + HTN (p=0.0023) cases. Conclusion. Depression is highly prevalent and has a direct significant association with various socio-demographic variables and anxiety in Indian patients with T2DM and/or HTN.

16

Obesity-diabetes-endocrinopathy – the metabolic connection

70%

Kozakowski J., Dudek P., Zgliczyński W.

European Journal of Clinical and Experimental Medicine

|

2022

|

issue 4

459-469

EN

Introduction and aim. The article outlines the mechanisms of interrelationships between obesity, type 2 diabetes, and certain disorders of the endocrine system. The paper explains how insulin resistance develops, which is a key link between obesity and several related disorders, how hypercortisolemia leads to the development of obesity and glucose intolerance, why thyroid dysfunctions are bidirectionally associated with metabolic disturbances, in what way excessive body weight leads to the hypogonadism in men, or how menopause promotes the development of abdominal obesity, carbohydrate intolerance and, in some cases type 2 diabetes. Material and methods. Scientific articles were reviewed by searching for information using the online database with scientific articles, including PubMed, Google Scholar and other available scientific databases. Analysis of the literature. The huge prevalence of obesity, diabetes, and hormonal disorders (e.g., autoimmune thyroid disease, female and male hypogonadism) over the contemporary world together with the serious health consequences of these conditions makes up a specific triangle of metabolic connections, increasingly absorbing the human, organizational and financial resources of health systems. Conclusion. Recognizing the relationship between the components of this triangle and understanding the risks arising from this phenomenon may allow to effectively reduce its impact on our health.

17

Profilaktyka i leczenie cukrzycy typu 2 – walka z chorobą i edukacja zdrowotna

70%

Gostyńska M. M.

Kontrola Państwowa

|

2018

|

vol. 63

|

issue 4 (381)

60-76

EN

Diabetes is considered a civilisation disease whose treatment, since the diagnosis, continues throughout lifetime. This is a huge burden to the health insurance system. From the data of the National Health Fund (Polish: Narodowy Fundusz Zdrowia, NFZ) it transpires that the number of those suffering from type 2 diabetes exceeds 1.6 million. In fact, this number is higher since some persons having diabetes have never been diagnosed. That is why it is very important, for both the health system, and the patients themselves and their relatives, to have access to education, appropriate prevention and, once diagnosed, to start treatment as soon as possible so that not to develop complications or to delay them. Therefore, the Supreme Audit Office conducted an audit to evaluate the activities aimed at diagnosing those threatened with and suffering from type 2 diabetes at an early stage, and at implementing effective methods for treating the disease.

18

(Prze)żyć z cukrzycą w szkole

61%

Nowakowska H., Lewartowska-Zychowicz M.

Teraźniejszość – Człowiek – Edukacja

|

2018

|

vol. 21

|

issue 4(84)

87-97

EN

During the last decades of the 20th century diabetes type 1 was recognised in younger and younger members of European population and today the highest incidence rate is observed between the 10th and 14th year of life. It is estimated that all over the world there are about 440 thousand children under 15 with a recognised diabetes type 1. Diabetes type 1, as a chronic illness, is a significantly difficultexperience for a child, because it remarkably changes their lifestyle almost in all areas: functioning at home, at school, in relations with peers, as well as in the scope of pursuing passions and interests. Diabetes therapy must be carried out non-stop, through night and day. The key elements of treating that illness are numerously performed measurements during the day and night (from eight to 12 times) and recording the level of glycaemia in blood. The subject of our interest are the social school experiences (and to be more exact – the experience interpretations) of pupils suffering from diabetes. The method of “pure” netnography was used. The research material used in this study comes from the analysis of posts placed on the internet forum for diabetes patients – www.mojacukrzyca.org.pl. The reading of the posts of pupils touched by diabetes type 1 indicates their diverse experiences connected with daily functioning on the school territory and relations with peers. Those experiences are extremely different, from the ones full of empathy and acceptance from teachers’ and peers’ side to the hostile ones, characterised by negative emotions, e.g. jealousy.

PL

W ostatnich dekadach XX wieku w populacji europejskiej cukrzycę typu 1 rozpoznawano u coraz młodszych osób, dziś najwyższą zapadalność obserwuje się pomiędzy 10. a 14. rokiem życia. Ocenia się, że aktualnie na świecie żyje około 440 tys. dzieci poniżej 15. roku życia z rozpoznaną cukrzycą typu 1. Cukrzyca typu 1, jako choroba przewlekła, jest niezmiernie trudnym doświadczeniem dla dziecka, gdyż znacząco zmienia jego dotychczasowy tryb życia niemal we wszystkich wymiarach: funkcjonowania w domu rodzinnym, w środowisku szkolnym, w relacjach z rówieśnikami, a także w zakresie realizowania pasji i zainteresowań. Terapia cukrzycy musi być realizowana nieustannie, przez całą dobę. Kluczowymi elementami postępowania z tą chorobą są bowiem wielokrotnie wykonywane (od 8 do 12 razy) w ciągu doby pomiary oraz dokumentowanie poziomu glikemii we krwi. Przedmiotem naszego zainteresowania są doświadczenia społeczne (a dokładniej mówiąc interpretacje doświadczeń) uczniów chorujących na cukrzycę w ich środowisku szkolnym. W badaniu została wykorzystana metoda „czystej” netnografii. Materiał badawczy wykorzystany w niniejszym opracowaniu pochodzi z analizy postów zamieszczonych na forum internetowym do diabetyków www.mojacukrzyca.org.pl. Lektura postów uczniów, dotkniętych cukrzycą typu 1, wskazuje na ich zróżnicowane doświadczenia związane z codziennym funkcjonowaniem na terenie szkoły oraz relacjami z rówieśnikami. Doświadczenia te bywają skrajnie odmienne, od pełnych empatii i akceptacji ze strony nauczycieli i rówieśników po wrogie, nacechowane złymi emocjami, np. zazdrością.

19

An analysis of selected risk factors for myocardial infarction depending on gender

61%

Bujnowska M.

Zeszyty Naukowe Państwowej Wyższej Szkoły Zawodowej im. Witelona w Legnicy

|

2019

|

issue 2(31)

EN

The risk factors for the ischemic heart disease are divided into two main categories: modifiable and non-modifiable. Among the modifiable factors there are lipid disorders, smoking, overweight, hypertension, diabetes, stress and excessive alcohol consumption. Each of the above-mentioned factors contributes to the development of coronary heart disease and constitutes a serious threat to the public health. Aim. the aim of the study was to analyze the risk factors for myocardial infarction depending on gender. Material and methods. the study involved 315 patients (99 women and 216 men) aged 29 – 91 (with the average of 64), treated with coronary angioplasty. the main analyzed risk factors included: smoking, hypertension, hypercholesterolemia, diabetes, overweight, previous incidents of myocardial infarction, complications during hospitalization, death during hospitalization, type of change: de novo or in place of PCI, the number of hospitalization days. the statistical analysis was carried out using the Pearson nonparametric test, assuming statistical significance of p <0.05000. Results. 18.2% of the female respondents smoked tobacco, for male respondents this value stood at 66.2%. Hypertension occurred in 81.8% of women and in 33.8% of men. Hypercholesterolemia occurred in 60.6% of women and in 30.1% of men. Obesity occurred in 69.7% of women and in 59.3% of men. Diabetes was diagnosed in 77.8% of women and in 43.1% of men. Previous infarction occurred in 23.2% of women and in 22.7% of men. Conclusions. Women tend to have myocardial infarction at an older age. Women have more frequent atrioventricular blocks as a complication of myocardial infarction. Women are more likely to be affected by risk factors such as hypertension, hypercholesterolemia or diabetes. for men, smoking constitutes a more common risk factor of myocardial infarction.

PL

Czynniki ryzyka choroby niedokrwiennej serca dzieli się na dwie główne kategorie: modyfikowalne oraz niemodyfikowalne. Wśród czynników modyfikowalnych wymienia się zaburzenia lipidowe, palenie tytoniu, nadwagę, nadciśnienie tętnicze, cukrzycę, stres oraz nadmierne spożywanie alkoholu. Każdy z wyżej wymienionych czynników przyczynia się do rozwoju choroby wieńcowej i stanowi poważne zagrożenie zdrowia społeczeństwa. Cel pracy. Celem pracy była analiza występowania czynników ryzyka zawału mięśnia sercowego w zależności od płci. Materiał i metody. Badaniu poddano 315 pacjentów (99 kobiet i 216 mężczyzn) w wieku od 29 do 91 (średnia 64) lat, leczonych za pomocą angioplastyki wieńcowej. Głównymi czynnikami, które poddano analizie, były czynniki ryzyka: palenie tytoniu, nadciśnienie tętnicze, hipercholesterolemia, cukrzyca, nadwaga, wcześniej przebyty zawał, powikłania w trakcie hospitalizacji, zgon w trakcie hospitalizacji, rodzaj zmiany: de novo lub w miejscu PCI, ilość dni hospitalizacji. Analizę statystyczną przeprowadzono za pomocą testu nieparametrycznego Pearsona, przyjmując istotność statystyczną p < 0,05000. Wyniki. Wśród kobiet 18,2% badanych paliło tytoń, wśród mężczyzn grupę tę stanowiło 66,2% pacjentów. Nadciśnienie tętnicze występowało u 81,8% kobiet i 33,8% mężczyzn. Hipercholesterolemia występowała u 60,6% kobiet i 30,1% mężczyzn. Otyłość występowała u 69,7% kobiet i 59,3% mężczyzn. Cukrzycę zdiagnozowano u 77,8% kobiet i 43,1% mężczyzn. Wcześniej przebyty zawał występował u 23,2% kobiet i 22,7% mężczyzn. Wnioski. Kobiety w późniejszym wieku chorują na zawał mięśnia sercowego. U kobiet częściej występują bloki przedsionkowo-komorowe jako powikłanie zawału mięśnia sercowego. U kobiet częściej występują czynniki ryzyka takie jak: nadciśnienie tętnicze, hipercholesterolemia czy cukrzyca. U mężczyzn częściej występuje czynnik ryzyka ozw (ostre zespoły wieńcowe) taki jak palenie tytoniu.

20

Efficacy of Lepidium Sativum to act as an anti-diabetic agent

61%

Mishra N., Mohammed A., Rizvi S.

Progress in Health Sciences

|

2017

|

vol. 7(1)

44-53

EN

Objective: Lepidium sativum, commonly known as chandrashoor in India, has been used in the Indian traditional medicine system for the treatment of various diseases. The present study was undertaken to investigate the hypoglycemic effect of Lepidium sativum in normal and streptozotocin-induced diabetic rats. Materials and methods: Thirty (30) adult male Wistar rats weighing 157±51g were randomly assigned to five groups of six rats each as Normal control, Diabetic control, Diabetics supplemented with Lepidium sativum extract, Diabetics treated with insulin, and Normal rats supplemented with Lepidium sativum. All rats were fed with a normal laboratory diet, nutrient rich pellets, and had free access to drinking water. The rats were injected with streptozotocin at a dose of 45 mg/kg body weight intraperitoneally to induce diabetes. The extracts were then given orally to different groups of rats at a dose of 20mg/kg body weight for 16 days. Thereafter, the rats were sacrificed, and blood samples collected by cardiac puncture were used for the determination of Glucose, Creatinine, Alkaline Phosphatase, Cholesterol, Malondialdehyde level, % DPPH, and FRAP content. Results: Administration of lepidium extract showed a significant reduction in glucose, creatinine, and alkaline phosphatase levels. Elevated cholesterol level was restored approximately to normal; a significant decrease in malondialdehyde levels was also observed compared to diabetic controls. Conclusion: Lepidium sativum extract shows efficacy in the prevention and management of diabetes mellitus and its related complications.

Refine search results

Complex relationships between endocrinopathies and obstructive sleep apnea syndrome

An analysis of the level of knowledge about diabetes among pregnant women

Influence of food-derived advanced glycation end products on health

Glucagonoma as a rare case of neuroendocrine tumor of the pancreas: a case report

An evaluation of the prevalence of autoimmunological diseases in patients with diabetes and obesity hospitalized in the Department of Diabetology, Rural Medicine Institute in Lublin

What next for diabetes mellitus?

Potoczna wiedza o cukrzycy: porównanie osób posiadających i nieposiadających chorego na cukrzycę w rodzinie

Association between a nucleotide polymorphism in the calpain 10 gene and carbohydrate metabolism disturbances in patients with polycystic ovary syndrome

Disorders of carbohydrate metabolism and their relationship with the prevalence of cancer in patients with acromegaly – authors’ own observations

Wpływ stylu zachowania na jakość życia chorych z cukrzycą, poziom samoopieki oraz parametry kliniczne.

Rys historyczny badań nad doustnymi lekami przeciwcukrzycowymi z klasy gliflozyn

Estimating the confidence interval of the regression coefficient of the blood sugar model through a multivariable linear spline with known variance

Poverty, Obesity, Diabetes: Are They the By-Products of Liberalization of Global Economy?

Porównanie form prowadzenia dzienniczka samokontroli cukrzycy w kontekście zarządzania wiedzą pacjentów i podnoszenia jakości samokontroli

Prevalence of depression in Indian patients with type 2 diabetes mellitus and/or hypertension: DEPTH Study

Obesity-diabetes-endocrinopathy – the metabolic connection