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Evaluation of manufacturing specification of antifungal vaccines

100%
NEDOSEKOV V., MARTYNYUK O., STETSIURA L.
Edukacja-Technika-Informatyka
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2016
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vol. 7
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issue 1
158-162
EN
In this article are presented the algorithm of manufacture vaccines against dermatomycoses carnivores based on original research stages manufacture of vaccines. Shown biotechnological aspects of selection isolates the study of immunological properties of strains of dermatophytes, ways to optimize cultivation conditions and methods of working hours of raw material. The basic stages of biotechnology development inactivated vaccines against dermatomycoses dogs and cats, for example vaccines “Funhikanifel” inactivated associated against dermatomycoses dogs and cats. The authors have developed technological regulation manufacture of vaccines against dermatomycoses, allowing for high immunogenic properties and the harmlessness for immunization of dogs, cats and laboratory animals. In the article focuses on the selection of iso-lates of dermatophytes on morphological features that will continue to be crucial in the production of highly effective vaccine. Experimentally, the possibility of a vaccine using domestic raw materials, which has priority from the standpoint of national biosafety.
2

CXCR4+ and CCR5+ expression on blood lymphocytes and its changes in AIDS development in HIV/HCV coinfected patients

75%
Matsiyeuskaya N., Tsyrkunov V., Hancharou A.
Progress in Health Sciences
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2012
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vol. 2
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issue 2
12-20
EN
Purpose: To measure the CCR5+ and CXCR4+ expression on blood lymphocytes, its changes in AIDS development, and correlation of CCR5+ and CXCR4+ expression with a number of T-cells, T-helpers, cytotoxic T-cells, activated T-cells (CD3+ HLA-DR+), T-regs cells, natural killer (NK)-cells, B cells, in order to determine the type of immune response activation in HIV/HCV coinfected patients. Materials and methods: The patients were divided into four groups. The 1st group included 51 patients with HIV/HCV coinfection; the 2nd group consisted of 23 patients with HIV-infection; the 3rd group was composed of 10 patients with HCV-infection. Control group consisted of 16 healthy individuals. In the current investigation, the monoclonal antibodies were used. The cells were analyzed using flow cytometer. Results: In patients with HIV/HCV coinfection СXCR4 expression on blood lymphocytes was reduced in comparison with control. СCR5 expression on blood lymphocytes, HLA-DR expression on CD3+lymphocytes and cytotoxic T- cells, numbers of CD8 T-lymphocytes were increased and in the same time the number of CD4+CD25+ was reduced in HIV/HCV coinfected patients in comparison with the HCV-infected patients and control group. Conclusions: In chronic HIV/HCV coinfected patients СCR5+ expression on blood lymphocytes was increased and СCR5+ expression on CD4+ T-lymphocytes was decreased in comparison with healthy individuals and HCV-infected patients. With the development of AIDS, CXCR4+ and CCR5+ expressions on CD4+T-lymphocytes, CXCR4+ expressions on blood lymphocytes were decreased and CCR5+ expression on blood lympho-cytes was increased. Increased СCR5+ expression on blood lymphocytes in HIV/HCV coinfected patients was associated with Th1 type immune response activation.
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