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Molecular hematology – modern methodology serving patients and research

100%
Witt M.
Nauka
|
2009
|
issue 4
PL
The article describes a country-wide attempt to organize a network of laboratories performing molecular diagnostic procedures in a context of clinical hematology. The principles of construction of a commissioned grant in molecular hematology are presented. A major result of this project, the monographic book on molecular hematology is being announced.
2
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The role of residence near hazardous waste sites containing benzene in the development of hematologic cancers in upstate New York

100%
Boberg E., Lessner L., Carpenter D. O.
International Journal of Occupational Medicine and Environmental Health
|
2011
|
vol. 24
|
issue 4
327-338
EN
Objectives: Epidemiologic studies suggest an association between environmental exposure to benzene and hematologic cancers, but the relationship is not fi rmly established. The aim of this study was to assess the potential association between residence near hazardous waste sites containing benzene and hospitalization discharge rates for persons having hematologic cancers. Materials and Methods: We determined the number of hospital discharges of people with hematologic cancers in New York State except for New York City for the years 1993 to 2008. Descriptive statistics and negative binomial regression models were used to compare the rates of hospitalization of residents in zip codes containing hazardous waste sites containing benzene to the rates of discharges from residents in zip codes without waste sites. Results: When adjusting for potential confounders we found a 15% increase in the rate of hospitalization for chronic lymphatic leukemia (CLL) [rate ratio (RR): 1.15; 95% confi dence interval (CI): 1.00–1.33], a 22% increase in the rate of discharges for total leukemia (RR: 1.22; 95% CI: 1.04–1.43) and a 17% increase in the rate of discharges for total lymphoma (RR: 1.17; 95% CI: 1.02–1.35) in the benzene exposed sites. We found greater effects of exposure in African Americans compared to Caucasians, females compared to males and people with higher socioeconomic status (SES) compared to those with lower SES for several of the diseases studied. Conclusions: After controlling for major confounders we found statistically signifi cant increases in discharge rates for several hematologic cancers in persons residing in zip codes containing benzene waste sites. These results provide additional support for a relationship between environmental exposure to benzene and risk of hematologic cancers.
3
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Chłoniak złośliwy czy choroba Kikuchi-Fujimoto – opis przypadku

86%
Syrek-Kaplita K., Karczmarek-Borowska B., Sałek A., Fudali L.
Medical Review
|
2013
|
issue 2
257–263
PL
Pacjentka lat 70, została skierowana do Ośrodka Onkologicznego z podejrzeniem chłoniaka złośliwego. Po wykonaniu badań i ponownej ocenie preparatów histopatologicznych rozpoznano chorobę Kikuchi- Fujimoto. Następnie chora została przekazana pod opiekę Poradni Reumatologicznej. Choroba Kikuchi- Fujimoto znana jako histiocytarne, martwicze zapalenie węzłów chłonnych bez nacieków granulocytarnych jest limfadenopatią o nieznanej etiologii. Po raz pierwszy została opisana w 1972 roku w Japonii, przez niezależnych badaczy Kikuchi i Fujimoto. Podczas diagnostyki pod uwagę bierze się choroby infekcyjne, autoimmunologiczne, nowotworowe- głównie rozrosty układu chłonnego lub przerzuty guzów litych. Podstawą rozpoznania jest potwierdzenie cech klinicznych oraz histopatologicznych. W terapii stosuje się leczenie objawowe, ale w większości przypadków zmiany ulegają samoistnej regresji.
EN
The case is a 70-year-old female patient, who was directed to the Oncology Center with suspected malignant lymphoma. The evaluation and histopathological reexamination suggested Kikuchi-Fujimoto disease. The patient was then referred to a Rheumatology Clinic. The Kikuchi-Fujimoto disease or histiocytic, necrotizing lymphadenitis without granulocytic infiltration is a lymphadenopathy of unknown etiology. It was first described in Japan by independent researchers Kikuchi and Fujimoto in 1972. During the diagnostic workup infectious, autoimmune, or neoplastic diseases are taken into consideration. The diagnosis is confirmed both by clinical and histopathological features of the disease. Symptomatic treatment is administered, but the changes regress spontaneously in most cases.
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