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Physical possibilities in the treatment of chronic abdominal pain in patients with peritoneal adhesions

100%
Pasek J., Senejko M., Cieślar G.
Family Medicine & Primary Care Review
|
2019
|
issue 2
124-129
EN
Background. The most intensive pains suffered by patients after surgical interventions are caused by post-operative peritoneal adhesions, which are incorrect connective tissue connections formed on or among internal organs and tissues in the abdominal cavity. These adhesion-related pains are resistant to analgesic treatment and often persist for many years. Objectives. In this trial, the estimation of the efficacy of combined treatment with the use of two variable magnetic field related therapeutic methods (magnetotherapy and magnetostimulation) in the treatment of 119 patients with chronic abdominal pains caused by numerous post-operative peritoneal adhesions was performed. Material and methods. 67 patients from the examined group were subjected to two series of 20 daily procedures of exposure to variable magnetic fields in the form of magnetotherapy and magnetostimulation, while 52 patients from the comparison group were subjected to sham exposure, during which no magnetic field was generated in the applicators. Prior to the therapeutic cycle and after its completion, the assessment of pain intensity, with the use of the Visual Analogue Scale (VAS ), and subjective estimation of quality of life, by means of the EuroQol Scale, were performed. Results. In patients from the examined group, a significant decrease in pain intensity, according to the VAS , and a significant improvement of life quality level, on the EuroQol Scale, in comparison to initial values, was achieved (8.0 ± 1.1 vs 2.3 ± 1.0 points, and 30.2 ± 14.1 vs 86.2 ± 8.5 points, respectively (p < 0.05); while in the control group, no statistically significant changes of the estimated parameters were observed. Conclusions. Magnetotherapy and magnetostimulation are efficient therapeutic methods in the case of patients with long-lasting abdominal pain related to peritoneal adhesions, enabling an improvement in their life quality (regardless of gender and age). Taking into account that magnetotherapy and magnetostimulation are not applicable in primary care, family doctors should consider a consultation with a physical therapy specialist in order to prescribe a cycle of physical treatment with the use of these methods in the case of such patients with drug-resistant abdominal pain caused by diagnosed postoperative peritoneal adhesions
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The influence of the low-frequency magnetic fields of different parameters on the secretion of cortisol in men

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Woldańska-Okońska M., Czernicki J., Karasek M.
International Journal of Occupational Medicine and Environmental Health
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2013
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vol. 26
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issue 1
92-101
EN
Objectives: The aim of this paper is to test the infl uence of long-term application of the low-frequency magnetic fi elds in magnetotherapy and magnetostimulation on cortisol secretion in men. Materials and Methods: Patients were divided into three groups: 16 men underwent magnetotherapy and 20 men (divided into two groups) underwent magnetostimulation. Magnetotherapy – 2 mT induction, 40 Hz, bipolar square wave, was applied for 20 min to lumbar area. Magnetostimulation (Viofor Jaroszyk, Paluszak, Sieroń (JPS) system, M2P2 program) was applied to 10 patients for 12 min each day. The third group (10 patients) underwent magnetostimulation (Viofor JPS system, M3P3) for 12 min each day using a different machine. All groups had 15 rounds of applications at approximately 10:00 a.m. with intermissions on the weekends. Blood serum was taken four times in a 24-hour period, before applications, the day after applications and a month later. Chemiluminescence micromethod was used to indicate hormone concentrations. Data was statistically analyzed with the analysis of variance (ANOVA) method. Results: The statistically signifi cant gains in the circadian cortisol profi le at 4:00 p.m., before and after application, were observed as a decrease in concentration during magnetotherapy. In magnetostimulation, with the M2P2 program, a signifi cant increase in the cortisol concentration was observed in circadian profi le at 12:00 p.m. one month after the last application. After magnetostimulation with the M3P3 program, a signifi cant increase in concentration at 6:00 a.m. and a decrease in concentration at 12:00 p.m. were observed one month later. Statistically signifi cant difference was demonstrated in the participants after the application of magnetotherapy and magnetostimulation with M3P3 program compared to the men submitted to magnetostimulation, with M2P2 program, at 4:00 p.m. after 15 applications. Conclusions: Biological hysteresis one month after magnetostimulation suggests long-term infl uence on the hypothalamohypophysial axis. The circadian curves of cortisol secretion a day after magnetotherapy and magnetostimulation with M3P3 program compared to magnetostimulation with M2P2 progam differs nearly by 100%, which proves that they show varied infl uence on cortisol secretion in men. All changes in the hormone concentration did not exceed the physiological standards of cortisol secretion, which suggests a regulating infl uence of magnetic fi elds on cortisol concentration rather than a strong stressogenic impact of magnetostimulation.
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Occupational exposure to 50 Hz magnetic fields does not alter responses of inflammatory genes and activation of splenic lymphocytes in mice

75%
Luo X., Jia S., Li R., Gao P., Zhang Y.
International Journal of Occupational Medicine and Environmental Health
|
2015
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vol. 29
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issue 2
277-291
EN
Objectives The objective of the present study was to observe the effects of 50 Hz magnetic fields (MFs) on the immune function of splenic lymphocytes in mice. Material and Methods Twenty male Kunming mice (6 weeks old), weighing 18– 25 g, were randomly divided into sham exposure (N = 10) and 500 μT MFs (N = 10) groups. The mice in the MFs group were exposed to 500 μT MFs for 8 h daily (5 days/week) for up to 60 days. In vitro study was carried out to examine the effects of 50 Hz MFs on the expression of inflammatory factor genes and a cluster of differentiation 69 (CD69) in mouse prime splenic lymphocytes activated by para-Methoxyamphetamine (PMA) and ionomycin. In the in vitro experiments, lymphocytes were isolated from the spleen of 10 healthy Kunming mice, the cells were cultured in the Roswell Park Memorial Institute 1640 medium (RPMI-1640) and exposed to 0 μT, 250 μT, 500 μT, or 1 mT MFs in an incubator under 5% carbon dioxide (CO₂) at 37°C for 6 h. The levels of interleukin-2 (IL-2), IL-4, interferon-gamma (IFN-γ), GATA binding protein 3 (GATA-3) and T cell-specific T-box transcription factor (T-bet) were assessed by the real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR), respectively. The expression of CD69 was checked using the flow cytometry. Results Under our experimental conditions, body weight of the mice exposed to occupational, extremely low frequency- electromagnetic fields (ELF-EMFs) significantly decreased on day 20 and day 30. There were no significant changes observed in vivo in spleen weight, splenic coefficient, splenic histology profile and cytokine production in spleen tissues. Our in vitro experiments showed that 50 Hz MFs had no effect on the expression of these genes and CD69 to primary splenic cells. Conclusions In conclusion, under the applied experimental conditions, occupational exposure to 50 Hz magnetic field did not alter responses of inflammatory genes and activation of splenic lymphocytes in mice, except for body weight.
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