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Mitochondrial diseases

88%
EN
Mitochondria are found in every nucleated cell of the human body. The major function of these cell compartments is energy production. Mitochondria are the only orgenalles of the human cells that have their own genetic material – mitochondrial DNA, that is because of their bacterial ancestry. Mutations in the mtDNA as well as in the nuclear genome cause mitochondrial diseases, the symptoms of which are very diverse. Mitochondrial dysfunction is a common phenomenon of many disorders, also of neurodegenarative diseases.
PL
Epilepsy in children leads to disorders in their psychomotor development or the loss of their acquired skills. Successful pharmacological treatment of epilepsy provides grounds for effective therapeutic measures. The goal of this article is to present the dynamics of neurodevelopmental disorders in the course of the severe symptomatic epilepsy with status epileptici which affected a 10-year-old girl. As a result of longitudinal studies, four stages were distinguished which determined the dynamics of development of the disease: 1) up to the age of 10, when the child’s psychomotor development proceeded correctly, 2) between the ages of 10 and 15, when, because of epilepsy, the disorders in the cognitive, linguistic, emotional, behavioural, motor, and vegetative spheres occurred, which assumed the form of profound dementia, 3) between the ages of 16 and 17, when the balance of the bioelectric activity of the brain was achieved owing to the optimisation of pharmacological treatment, 4) between the ages of 17 and 25, when, after the multi-specialist therapy, there was a significant improvement in the functioning of all the disordered spheres, which enabled the patient to finish junior and senior high school, apply to a university, obtain very good results in learning, and to achieve spectacular successes in sport.
Logopedia
|
2021
|
vol. 50
|
issue 2
117-134
EN
SARS-CoV-2 pandemic has attracted a variety of research concerning direct and indirect repercussions of COVID-19 in terms of human linguistic and cognitive functions. The following article is an overview focusing on neurological complications of coronavirus infection presenting with cognitive and linguistic disfunctions defined as COVID-19 brain fog. The aim of the article is to demonstrate current clinical studies and to set a paradigm with regard to the issues of diagnosing and treating patients who recovered from COVID-19.
PL
W dobie pandemii SARS-CoV-2 prowadzone są badania dotyczące bezpośrednich i odległych skutków zachorowania na COVID-19 dla językowego i poznawczego funkcjonowania człowieka. Niniejszy artykuł ma charakter przeglądowy, koncentruje się wokół neurologicznych powikłań zakażenia koronawirusem SARS-CoV-2 przejawiających się trudnościami poznawczymi i językowymi, określanymi jako „mgła covidowa”. Celem opracowania jest przedstawienie aktualnego stanu badań klinicznych i ustalenie paradygmatu problemów dotyczących diagnozy i terapii logopedycznej osób, które przechorowały COVID-19.
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