This paper presents an attempt to formalize the concept of the Triple Helix of university-government-industry interactions as a prototype of an innovation ecosystem. Such a formalization is based on game theory principles, methods and models, as well as the methods and instruments of the theory of optimal allocation of resources. The constructed game-theoretic model simulates the phases of R&D, the implementation and commercialization of a new project, as well as the risks and uncertainty in each of these innovation stages.
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