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Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

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Polańska K., Ligocka D., Sobala W., Hanke W.
International Journal of Occupational Medicine and Environmental Health
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2016
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vol. 29
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issue 4
683-697
EN
Objectives The objective of this study was to evaluate the impact of phthalate exposure on pregnancy duration and birth outcomes based on the Polish Mother and Child Cohort (REPRO_PL). Material and Methods Phthalate exposure was determined by measuring 11 phthalate metabolites (mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), 3OH-mono-n-butyl phthalate (OH-MnBP), mono-benzyl phthalate (MBzP), mono‑ (2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-hydroxy-iso-nonyl phthalate (MHiNP), mono-oxo-iso-nonyl phthalate (MOiNP), and mono-n-octyl phthalate (MOP)) in the urine collected from 165 mothers during the third trimester of pregnancy by high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The following measures at birth were considered: gestational age, birth weight, length as well as head and chest circumference. Results Pregnancy duration was inversely associated with natural log concentrations (μg/g creatinine) of MEP (standardized regression coefficient (β) = –0.2, p = 0.04) after adjustment for a variety of confounders. Significant impact of MOiNP on head circumference (β = –0.1, p = 0.05) was also observed. Conclusions The study findings add further support to the hypothesis that phthalate exposure may be associated with shorter pregnancy duration and a decreased head circumference, and underscore importance of public health interventions to reduce that exposure.
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Environmental non-persistent endocrine-disrupting chemicals exposure and reproductive hormones levels in adult men

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Dziewirska E., Hanke W., Jurewicz J.
International Journal of Occupational Medicine and Environmental Health
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2018
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vol. 31
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issue 5
551-573
EN
Non-persistent endocrine-disrupting chemicals (EDCs) are exogenous, man-made substances present in the environment that may interfere with the natural human hormones and may exert adverse consequences on human organism. Endocrinedisrupting chemicals have been suspected to be associated with altered reproductive function in the case of males and females. Environmental endocrine-disrupting non-persistent chemicals like parabens, phthalates, bisphenol A (BPA), synthetic pyrethroids and organophosphate pesticides are found in various products such as metal food cans, plastic bottles, detergents, personal care products or chemicals used for fighting against insects. The widespread distribution of these chemicals causes that humans are permanently exposed through multiple sources. The aim of this review is to summarize data linking non-persistent endocrine-disrupting chemicals exposure, and human, male reproductive hormones levels. The included studies were selected by searched PubMed, Web of Science and MEDLINE, original papers published from 2006 to 2016 and referring to human data were included to the review. The results of reviewed studies were not consistent, however, majority of the studies indicated that non-persistent EDCs may affect male reproductive hormones levels. Most findings suggest that exposure to environmental EDCs is negatively related to the level of testosterone (except for exposure to BPA which is positively associated). In most of the studies negative association was found between exposure to examined EDCs and free androgen index, too. Considering the suggested health effect of exposure to EDCs, more epidemiological data is needed. Int J Occup Med Environ Health 2018;31(5):551–573
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Nadzór nad wyrobami z tworzyw sztucznych : Ochrona ludzi przed szkodliwym wpływem plastiku

67%
Szewczyk P., Wójcik K.
Kontrola Państwowa
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2021
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vol. 66
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issue 3 (398)
94-103
EN
The NIK carried out an audit, covering the whole country, of the activities of insti tutions that supervise plastics and plastic products designated for contact with food (bodies of the State Sanitary Inspectorate), and other plastic products, especially toys (bodies of the Trade Inspection). NIK examined whether they protected people against harmful effects of plastic. The audit comprised two central offices – the Chief Sanitary Inspectorate (GIS) and the Office of Competition and Consumer Protection (UOKiK), as well as twelve offices at the regional level, being part of the combined government administration: six regional sanitary and epidemiological centres, and six regional trade inspectorates.
PL
Rosnące zużycie tworzyw sztucznych stwarza coraz większe zagrożenia wynikające zarówno z braku popytu na produkty z recyklingu, jak i ich wpływu na środowisko i zdrowie człowieka. Plastik przedostaje się do żywności i wody pitnej, a problemem pozostaje również negatywne oddziaływanie niektórych dodawanych do niego substancji, takich jak ftalany czy bisfenol A, które działają szkodliwie na układ hormonalny i rozrodczy, szczególnie u dzieci. W trakcie kontroli tych zagadnień Najwyższa Izba Kontroli ustaliła, że dostępne na rynku materiały i wyroby przeznaczone do kontaktu z żywnością zasadniczo są bezpieczne. Wskazała natomiast słabe strony podejmowanych działań, zwłaszcza jeśli chodzi o zabawki zagrażające dzieciom.
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