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Evaluation of platelet indexes as potential biomarkers of suspected pulmonary embolism

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Mariusz Wójcik M., Joanna Daszyk-Wójcik J., Kamil Skoczyński K.
European Journal of Clinical and Experimental Medicine
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2019
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issue 2
113-117
EN
Introduction. Pulmonary embolism is one of the most frequent cardiovascular diseases, potentially leading to death. There is no validated biomarker with both high specificity and sensitivity. Aim. The aim of the study was to define the diagnostic importance of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) on acute pulmonary embolism. Material and methods. We retrospectively reviewed the medical records of 145 patients with clinically suspected acute pulmonary embolism admitted to the Emergency Department. Demographic data and laboratory tests were collected on admission. All patients underwent computed tomography (CT) angiography. Results. The total data of 145 patients were analyzed, including 65 patients (67±17 years; 30 men/35 women) with acute pulmonary embolism confirmed with CT and 80 patients (67±19 years; 26 men/54 women) with negative CT. The MPV did not differ between the patients with acute PE and the control group (8.0 fL [IQR: 7.6-8.4] vs. 7.9 fL [IQR: 7.4-8.7], p=0.45). There were no significant differences in PLT (220x10³/mm³ [IQR: 172-274] vs. 243x10³/mm³ [IQR: 186-286], p=0.12) and PDW (59.0 ± 6.9% vs. 57.2 ± 7.3%, p=0.12). Conclusions. Our results suggest that platelet indexes (at a single time point) are not a reliable diagnostic biomarkers of acute pulmonary embolism.
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Haematological changes among construction workers exposed to cement dust in West Bengal, India

75%
Mandal(Majee) A., Suva P.
Progress in Health Sciences
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2014
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vol. 4
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issue 1
88-94
XX
Purpose: This study measured haematological parameters in construction workers exposed to cement dust, silica and other hazardous materials. This was done in order to identify a simple, readily available, and cost effective screening test that could help to identify the presence of disease and its severity in workers potentially related to their work space. Materials and methods: The study was composed of 150 construction workers and 52 participants in an unexposed control group, with ages ranging from 15-60 years. Blood samples were collected from each participant and percentage of haemoglobin, total RBC count, WBC count, platelet count, and different RBC indices were analyzed. Results: The haemoglobin concentration, PCV, and MCV decreased significantly, but the MCHC and eosinophil counts increased significantly in comparison to the control group, though the increase in the monocyte count was not significant. No significant changes in haematological parameters with a year of exposure have been found. However, the percentage of prevalence of anaemia on the basis of haemoglobin concentration and PCV value were higher in construction workers in comparison to members of the control group. Conclusion: This study recommends that construction workers working in hazardous environments must support health education and should regularly use protective devices in their workplace. They must also have regular medical checkups, which might help detect disease in early stages.
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