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Infuence of HbA1c, serum lipids, blood pressure and BMI on Auditory Brainstem Response in diabetic patients

100%
Mariusz Dąbrowski M., Grażyna Mielnik-Niedzielska G., Andrzej Nowakowski A.
European Journal of Clinical and Experimental Medicine
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2017
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issue 3
185-191
EN
Introduction. Impaired hearing organ function including abnormalities in auditory brainstem response (ABR) are more frequent in diabetic subjects compared to the general population. The aim of our study was to assess the impact of selected modifiable factors on ABR latencies in diabetic subjects. Material and Methods. 58 patients with type 1 and type 2 diabetes, aged <45 years, with diabetes duration <10 years, and without clinically overt hearing impairment or diabetic neuropathy, were included. In all subjects vital signs and blood samples were obtained, and ABR audiometry was performed. Results. Significantly delayed latencies in ABR were found in patients with total cholesterol <192 mg/dL, with HDL-cholesterol <49.5 mg/dL, with triglycerides >89 mg/dL, with presence of hypertension, and with systolic and diastolic blood pressure >135 and >78 mm Hg respectively. A linear correlation between triglycerides and wave I and III latencies, and between systolic blood pressure and wave III latency were revealed. A relationship between ABR latencies and HbA1c, LDL-cholesterol or BMI was not found. Conclusions. Several modifiable factors affect functioning of the retrocochlear part of the auditory pathway. If these results were confirmed in further studies, a vast area of possible therapeutic interventions to preserve hearing function in diabetic patients would become available.
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How dose walking exercise affect serum lipids in underweight female adults?

80%
Habibzadeh N.
Progress in Health Sciences
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2015
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vol. 5
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issue 2
249-252
EN
Introduction:Fat profile is an extremely important substrate for muscle contraction, both at rest and during exercise as yet, there is still no clear consequence of exercise on lipid profile regulation in underweight subjects and thus the purpose of this study was to compare lipids serums in underweight young women (BMI≤ 20) before and after walking intervention.Materials and methods:20 underweight young non-athlete women volunteered to participate in this study and then they were randomly assigned into two exercise (E: n=10, BMI=17.8±1.2, age: 21.1±1.7yr) and control (C: n=10, BMI=17.5 ±1.1, age: 21.9 ± 1.2) groups. Pre and post assessment were contained somatic (age, height, weight, BMI) and lipids profile (FBS, LDL, HDL, triglycerides and totalcholesterol) measurements. Exercise programme was consisted of 30-minutesupervised walking exercise at 60 % HR max at intensity equal with 40% VO2max 3 days per week for 2 months.Results:Data analysis showed post-BMI as well as body weight did not altered in comparison with pre - exercise programme (p>0.05). Subsequently all post - lipids variables included FBS, LDL, HDL, triglycerides and totalcholesterol were elevated compared with pre- intervention walking exercise (p< 0.05.)Conclusions:This study outlined that walking programme can be a stimuli toward ideal weight in slim individual because an increased lipids profile as indicators of an increased body mass in underwent individual who are at risk of diseases such as anorexia nervosa shows this notion. However, more investigation with longer duration is needed to justify thisconclusion.
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