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Innovative biodegradable dibutyrylchitin dressing for the treatment of ulcers occurring during chronic venous insufficiency in patients with type 2 diabetes

100%
Bieniek E., Skołucka-Szary K., Brzeziński J., Piaskowski S., Lewiński A.
International Journal of Occupational Medicine and Environmental Health
|
2021
|
vol. 34
|
issue 4
565-573
EN
The aim of this study was to assess the course of the healing process following the use of dibutyrylchitin (DBC) dressing, a fully degradable material used in the treatment of ulcers which occur during chronic venous insufficiency common in patients suffering from type 2 diabetes. These diseases have a significant impact on the patients’ standard of living, including the potential employment, and on the declining attendance at the current workplace. The implementation of this innovative therapeutic solution may positively affect the above-mentioned difficulties. An analysis of the healing process, following the application of the DBC dressing, was performed. Once the dressing was positioned on the wound, the analysis indicated that it underwent a process of degradation facilitated by the enzymes occurring naturally in the wound. When fully degraded, a further layer was applied. This process was repeated until the wound was fully healed. The study group consisted of 4 patients previously diagnosed with type 2 diabetes. During the observation period, the ulcers in all 4 cases had healed. The examined wound dressings adhered well to the wound surface and degraded within it. No side effects or adverse effects of the applied innovative therapy were observed. An addition of the biodegradable DBC dressing to the standard therapy procedure of ulcers occurring during chronic venous insufficiency among patients with type 2 diabetes indicate safe and effective treatment, which may have a direct reflection in the patient’s professional capacity enhancement. It resulted in the complete healing of all ulcers in each of the observed cases.
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Owrzodzenia podudzi i trudno gojące się rany

84%
Citko A.
Lek w Polsce
|
2022
|
vol. 373
|
issue 06
8-14
EN
In Poland, the most common types of difficult-to-heal wounds include: venous ulcers, pressure ulcers, ulcers associated with the diabetic foot syndrome, ischemic (arterial) ulcers and neoplastic wounds. In the local management of chronic wounds, the TIME strategy should be used (T – tissue and debridement – tissue preparation; I – infection and inflammation control – infection and inflammation control; M – moisture balance – wound moisture balance; E – edges – wound edges – no healing progress or undermining the edge of the wound and epidermization stimulation). The TIME strategy pays particular attention to reducing the risk of wound infection. The treatment of TIAB molecules [titanum argentum-benzoicum] in the treatment of chronic wound infection may be among the measures taken to reduce the risk of chronic wound infection. The introduction of nanotechnology and the combination of ionic silver nanoparticles with titanium dioxide by covalent bonds in the TIAB complex, revolutionized the effect of silver, many times increasing its antibacterial and antifungal properties, and removing its toxic effect by preventing accumulation in tissues. The precipitation of metallic silver from ionic compounds resulted in the loss of activity of the preparations and, with prolonged use, could lead to tissue damage. The patented form of TIAB silver on the titanium core has only an ionic / stable form of silver which is not reduced by exposure to light, as well as organic and inorganic compounds. TIAB silver is available in the form of a spray and cream, and has a proven effect on pressure ulcers and ulcers that heal difficult to heal. At the same time, it does not show any allergy to silver with prolonged use. The use of the TIAB molecule in the treatment of ulcers with symptoms of colonization was presented at the congress of the European Wound Treatment Society in 2012 in Vienna as a new and highly effective solution.
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