Search results

1

Vitamin C does not improve the efficacy of Helicobacter pylori eradication in smokers

100%

Namiot A., Namiot D., Bucki R., Kemona A., Kurylonek A., Namiot Z.

Progress in Health Sciences

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2020

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vol. 10(1)

77-81

EN

Purpose: To evaluate the hypothesis that vitamin C improves the efficacy of Helicobacter pylori eradication in smokers when combined with pantoprazole, amoxicillin, and clarithromycin. Materials and methods: The study completed 90 subjects of 98 enrolled, 58 smokers 32 nonsmokers. Helicobacter pylori status was determined by two methods, CLO test, and histology. Vitamin C (500 mg) was administered three times daily. The patients were considered as cured of H. pylori if the CLO test result and histology were negative 4 weeks after completion of eradication therapy. Results: Smokers had lower effectiveness of eradication therapy than non-smokers and the administration of vitamin C had not affected the outcome of eradication therapy. Conclusions: Vitamin C (500 mg tid) does not improve the eradication therapy when pantoprazole, amoxicillin, and clarithromycin were used.

2

Protective role of black tea and vitamin C during sub-acute toxicity of carbofuran in rats

88%

Kumar D., Sharma B., Rizvi S.

Progress in Health Sciences

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2016

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vol. 6(2)

148-154

EN

Purpose: Carbofuran toxicity on rats was studied during sub-acute exposure. This work was undertaken to evaluate the protective effect of aqueous black tea extract and vitamin C against a rat model of oxidative stress induced by treatment with carbofuran, an organocarbamate insecticide. Materials and methods: The levels of lipid peroxidation, reduced glutathione and ascorbic acid were assessed by determining the extent of oxidative stress in the erythrocytes of rats. Results: The results clearly demonstrated that the treatment of rats with sub-acute concentration of carbofuran caused significant elevation in the levels of oxidative stress and decrease in the contents of glutathione and ascorbic acid. The introduction of black tea extract and vitamin C augmented the antioxidant defense mechanism in alleviating the carbofuran induced oxidative stress. Conclusion: The findings that the pretreatment with black tea and vitamin C can mitigate carbofuran induced toxicity lend evidence that supplementation with either black tea extract and/or vitamin C have a therapeutic potential in amelioration of oxidative stress in mammalian systems

3

Can the effects of chromium compounds exposure be modulated by vitamins and microelements?

75%

Sijko M., Janasik B., Wąsowicz W., Kozłowska L.

International Journal of Occupational Medicine and Environmental Health

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2021

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vol. 34

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issue 4

461-490

EN

Chromium (Cr) is a very common element. It occurs in 2 oxidation states, Cr(III) and Cr(VI). Although Cr(III) is not considered an element essential for mammals, it raises lots of controversy due to its role in the body. While Cr(III) action should be considered an effect of pharmacological action, Cr(VI) is included in the first group of carcinogens for humans. Moreover, it induces numerous pathological changes in the respiratory, urinary, reproductive and digestive systems. In addition, Cr(VI) is used in many industry branches, causing millions of workers all over the world to be exposed to Cr(VI) compounds. A considerable number of the occupationally exposed individuals are in favor of a deep analysis of the mechanisms of Cr(VI) action and a search for a way to reduce its negative impact on the human body. Numerous reactive oxygen species inducing oxidative stress and causing various damage are produced during Cr(VI) reduction in the cells. A good balance between antioxidants and pro-oxidants can reduce Cr(VI)-induced damage. The influence of vitamins and microelements on the adverse Cr(VI) effects has no systematic research results summary. Therefore, this work focuses on the role of dietary antioxidants such as vitamins and microelements in the prevention of Cr(VI) adverse health effects. Numerous studies have revealed a protective influence of vitamins (mainly vitamins E and C) as well as microelements (especially selenium) on the reduction of Cr(VI)-induced adverse changes. A potential protective effect of these ingredients may be useful in occupational groups that are particularly exposed to Cr(VI). However, more research in this area is required.

4

The role of well-known antioxidant vitamins in the prevention of cadmium-induced toxicity

75%

Sitek A., Kozłowska L.

International Journal of Occupational Medicine and Environmental Health

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2022

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vol. 35

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issue 4

367-392

EN

Long-term exposure to cadmium (Cd) leads to the development of a number of conditions associated with liver and kidney damage, reproductive and cardiovascular disorders, in addition to visual impairment, blindness and hearing loss, among others. Cadmium has been classified as a human carcinogen by the International Agency for Research on Cancer. The toxicity of Cd is related to its pro-oxidant properties and the associated increase in oxidative stress. Antioxidant ingredients may be helpful in preventing the adverse effects of Cd. The effect of well-known antioxidant vitamins (E, C, A and β-carotene) in the prevention of Cd-induced toxicity is presented in this study. Numerous studies in animal models have shown that the effects of vitamins: E, C, A, and β-carotene were effective in reducing Cd concentrations in organs and tissues and reduced Cd-induced changes in liver, kidney, and reproductive, circulatory, nervous, immune, and respiratory systems. In contrast, the limited number of human studies does not allow to accurately determine the role of these nutrients in reducing Cd-induced toxicity, indicating the need for further studies clarifying the role of antioxidant vitamins in reducing Cd-induced toxicity. However, it seems reasonable to promote the consumption of natural food products that are sources of antioxidant vitamins in groups of people with occupational and environmental exposure to Cd.

5

Camino de Santiago jako naturalna terapia

63%

Seryczyńska B.

Studia Gdańskie

|

2018

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issue 43

285-293

PL

Punktem wyjścia niniejszego opracowania jest teza o skuteczności naturalnych środków terapeutycznych, do których grona zaliczono pielgrzymowanie Camino de Santiago drogą św. Jakuba. W pierwszej kolejności wśród wybranych naturalnych metod terapeutycznych nastąpi omówienie pozytywnych efektów kuracji za pomocą witaminy C. Następnie zostaną ukazane korelacje z Camino de Santiago pod względem dwóch zasadniczych elementów zapewniających skuteczność terapii witaminą C: użytej dawki oraz częstotliwość jej podawania. Całość rozważań doprowadzi do konkluzji o wciąż niedocenianej wartości naturalnych i prostych środków terapeutycznych.

EN

The starting point of this study is the hypothesis of the effectiveness of natural therapeutic measures, which include making the Camino de Santiago pilgrimage following the way of St. James. First of all, among the selected natural therapeutic methods, the positive effects of treatment with vitamin C will be discussed. Next, the correlations with Camino de Santiago will be shown in terms of two essential elements of vitamin C therapy: the dose used and the frequency of its administration. The whole discussion will lead to conclusions about the still underestimated value of simple and natural therapeutic means.

6

Ocena stężenia witamin antyoksydacyjnych u osób z zespołem metabolicznym pracujących w rolnictwie

51%

Godala M., Gaszyńska E., Moczulski D., Materek-Kuśmierkiewicz I., Krzyżak M.

Medycyna Pracy

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2021

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vol. 72

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issue 2

123-129

EN

Background: Vitamins A, C and E are important parts of the antioxidant barrier. Polish data on antioxidant vitamins deficiency in the population are rare, especially among physically active people with metabolic disorders. The aim of this study was to evaluate the serum concentrations of vitamins A, C and E in people with metabolic syndrome (MS) working in agriculture, the prevalence of their deficiency in these workers, and the correlation between antioxidant vitamins concentration and traditional biomarkers of cardiovascular diseases. Material and Methods: The study included 332 residents of the Łódź Voivodeship working in agriculture: 231 people with MS and 101 healthy ones. The serum concentrations of vitamins A, C and E were assessed using the chemiluminescent immunoassay technology. The antioxidant vitamins intake was assessed by means of a 24-h recall questionnaire using Diet 5.0 software. Results: The mean serum concentrations of vitamins A, C and E were significantly lower in the MS workers than in the healthy ones No correlation was found between the antioxidant vitamins concentration and the dietary intake but there was a correlation between the antioxidant vitamins concentration and high-density lipoprotein cholesterol (HDL-C). A correlation was found between the serum concentrations of vitamins A and C, and vitamins A and E, in the MS workers. Conclusions: The serum concentrations of antioxidant vitamins in the MS workers were significantly lower than in the healthy controls, despite the similar physical activity level. The dietary intake had no impact on the serum concentrations of these vitamins. The HDL-C concentration in the MS workers correlated with the concentrations of all antioxidant vitamins.

PL

Wstęp: Witaminy A, C i E stanowią ważną barierę antyoksydacyjną. Danych dotyczących stanu odżywienia populacji polskiej witaminami antyoksydacyjnymi jest niewiele, a szczególnie mało dotyczy osób aktywnych fizycznie z zaburzeniami metabolicznymi. Celem badania była ocena stężenia witamin A, C i E w surowicy krwi i częstości ich niedoborów u osób z zespołem metabolicznym (ZM) pracujących w rolnictwie oraz zależności między stężeniem witamin antyoksydacyjnych w surowicy a tradycyjnymi biomarkerami chorób sercowo-naczyniowych. Materiał i metody: W badaniu wzięło udział 332 mieszkańców województwa łódzkiego pracujących w rolnictwie: 231 osób z ZM i 101 osób zdrowych. Stężenie witamin A, C i E w surowicy krwi badano za pomocą wysokosprawnej chromatografii cieczowej, a spożycie witamin z dietą oceniano za pomocą programu Dieta 5.0 na podstawie 24-godzinnych wywiadów żywieniowych. Wyniki: Średnie stężenia witamin A, C i E w surowicy krwi osób z ZM były istotnie mniejsze niż w grupie bez ZM. Stężenie nie korelowało ze spożyciem witamin z dietą, ale korelowało ze stężeniem cholesterolu HDL. Stwierdzono korelację między stężeniem w surowicy witamin A i C oraz A i E u pracowników z ZM. Wnioski: Stężenie witamin antyoksydacyjnych w surowicy pracowników z ZM było istotnie mniejsze niż w grupie osób zdrowych, mimo podobnego poziomu aktywności fizycznej. Wysokie spożycie witamin z dietą nie różnicowało ich stężenia w surowicy osób z ZM zatrudnionych w rolnictwie. Stężenie cholesterolu HDL u osób z ZM korelowało ze stężeniem wszystkich witamin antyoksydacyjnych.

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2 International Journal of Occupational Medicine and Environmental Health

2 Progress in Health Sciences

1 Medycyna Pracy

1 Studia Gdańskie

2 Kozłowska L.

1 Bucki R.

1 Gaszyńska E.

1 Godala M.

1 Janasik B.

1 Kemona A.

1 Krzyżak M.

1 Kumar D.

1 Kurylonek A.

1 Materek-Kuśmierkiewicz I.

1 Moczulski D.

1 Namiot A.

1 Namiot D.

1 Namiot Z.

1 Rizvi S.

1 Seryczyńska B.

1 Sharma B.

1 Sijko M.

1 Sitek A.

1 Wąsowicz W.

1 2022

2 2021

1 2020