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  1. 1 Acta Medicorum Polonorum

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  1. 1 Stelmaszyk A.

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  1. 1 2016

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Rys historyczny badań nad doustnymi lekami przeciwcukrzycowymi z klasy gliflozyn

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Stelmaszyk A.
Acta Medicorum Polonorum
|
2016
|
vol. 6
|
issue 1
41-59
PL
Artykuł przedstawia historię odkrycia nowych leków przeciw cukrzycy typu 2, tzw. gliflozyn. Badania nad nimi prowadzone były w ciągu ostatniego półwiecza. Wykorzystano w nich związek wyizolowany z korzeni jabłoni w 1835 r. i odkryte w 1961 r. tzw. kotransportery. Wykazano, jakie glifozyny odkryto w latach 1999-2012. Przedstawiono zalety i wady tych drogich i nie refundowanych w Polsce leków.
EN
This article presents how new medicines against diabetes type 2, so called gliflozines, were discovered. Research on gliflozines were carried out during last fifty years. A chemical compound isolated in 1835 from the root of apple tree and discovered in 1961 so called membrane co-transporters were used in these experiments. The article shows which gliflozines were discovered in 1999-2012. Strong points and faults of these non-refundable in Poland medicines are described.
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